Understanding the comorbidities among psychiatric disorders, chronic low-back pain, and spinal degenerative disease using observational and genetically informed analyses
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Март 4, 2025
ABSTRACT
Psychiatric
disorders
and
symptoms
are
associated
with
differences
in
pain
perception
sensitivity.
These
can
have
important
implications
treating
spinal
degenerative
disease
(SDD)
chronic
low-back
(CLBP).
Leveraging
data
from
the
UK
Biobank
(UKB)
All
of
Us
Research
Program
(AoU),
we
investigated
effects
linking
psychiatric
(alcohol
use
disorder,
anxiety,
attention
deficit
hyperactivity
bipolar
cannabis
depression,
opioid
posttraumatic
stress
schizophrenia)
to
SDD
CLBP.
We
applied
multi-nominal
regression
models,
polygenic
risk
scoring
(PRS),
one-sample
Mendelian
randomization
(MR)
triangulate
underlying
associations
observed.
also
performed
gene
ontology
drug-repurposing
analyses
dissect
biology
shared
among
mental
illnesses,
SDD,
Comparing
individuals
affected
only
by
(UKB
N=37,745,
AoU
N=3,477),
those
CLBP
N=15,496,
N=23,325),
both
conditions
N=11,463,
N=
13,451)
controls
N=337,362,
117,162),
observational
genetically
informed
highlighted
that
strongest
across
three
case
groups
were
observed
for
alcohol
disorder.
Additionally,
schizophrenia
its
PRS
appeared
an
inverse
relationship
CLBP,
their
comorbidity.
One-sample
MR
a
potential
direct
effect
internalizing
on
outcomes
was
particularly
strong
SDD.
Our
identified
histone
deacetylase
inhibitors
as
targeting
molecular
pathways
disorders,
In
conclusion,
these
findings
support
comorbidity
is
due
contribution
health
outcomes.
pleiotropic
mechanisms
together
sociocultural
factors
play
key
role
shaping
SDD-CLBP
patterns
psychopathology
spectrum.
Язык: Английский
Fisetin reverses the negative effect of Lambda-Cyhalothrin on the maturation process of porcine oocytes in vitro by downregulating GRP78 levels
Ecotoxicology and Environmental Safety,
Год журнала:
2025,
Номер
294, С. 118064 - 118064
Опубликована: Март 26, 2025
Язык: Английский
Flavonoids in the regulation of microglial-mediated neuroinflammation; focus on fisetin, rutin, and quercetin
Experimental Cell Research,
Год журнала:
2025,
Номер
unknown, С. 114537 - 114537
Опубликована: Март 1, 2025
Язык: Английский
Research Progress of Flavonoids in Spinal Cord Injury: Therapeutic Mechanisms and Drug Delivery Strategies
Phytotherapy Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 2, 2025
Spinal
cord
injury
(SCI)
is
a
serious
neurological
disease
with
an
extremely
high
disability
rate.
Most
patients
show
loss
of
motor
and
sensory
functions
below
the
level
injury.
Current
treatment
protocols
are
based
on
early
surgical
decompression
pharmacotherapy.
However,
efficacy
these
interventions
suboptimal.
Due
to
its
complex
pathophysiological
mechanisms
difficulty
central
nervous
system
(CNS)
regeneration,
exploring
effective
therapeutic
remains
daunting.
Flavonoids
secondary
metabolites
unique
plants
that
have
attracted
attention
in
recent
years
for
their
potential
now
commonly
used
inflammation,
tumors,
other
diseases.
For
SCI,
related
studies
still
exploring;
some
compounds,
such
as
quercetin,
fisetin,
hesperetin,
shown
good
anti-inflammatory
anti-apoptotic
properties,
which
help
restore
function
injured
spinal
cord.
flavonoids
exhibit
certain
disadvantages,
including
poor
solubility,
low
bioavailability,
inability
achieve
long-term
controlled
release.
Some
proposed
drug
delivery
strategies-including
nanoparticles,
hydrogels,
collagen
scaffolds-to
enhance
efficacy.
In
this
paper,
we
summarize
strategies
SCI
by
searching
relevant
literature
propose
future
research
directions
provide
new
ideas
multimodal
SCI.
Язык: Английский
Fisetin: hormesis accounts for many of its chemoprotective effects
Biogerontology,
Год журнала:
2025,
Номер
26(2)
Опубликована: Апрель 1, 2025
Язык: Английский
Procaine regulates the STAT3/CCL5 axis and inhibits microglia M1 polarization to alleviate CFA rats pain behavior
eNeuro,
Год журнала:
2024,
Номер
11(12), С. ENEURO.0303 - 24.2024
Опубликована: Ноя. 14, 2024
Neuropathic
pain
(NP)
caused
by
sciatic
nerve
injury
can
significantly
impact
the
quality
of
life
patients.
The
M1
phenotype
microglia
has
been
reported
to
promote
progression
NP.
Procaine
is
a
lipid-soluble
local
anesthetic
drug
that
exerts
narcotic
analgesic
effects.
Nevertheless,
detailed
effect
procaine
in
NP
not
clear.
In
order
explore
role
polarization
microglia,
HAPI
cells
were
exposed
LPS
polarize
into
type.
addition,
number
was
assessed
using
flow
cytometry.
binding
site
between
CCL5
and
STAT3
explored
dual
luciferase
assay.
Furthermore,
vivo
experiments
applied
for
testing
on
inhibited
cell
viability,
which
reversed
procaine.
Consistently,
alleviated
LPS-induced
upregulation
inflammatory
factors.
Additionally,
it
induced
LPS.
Meanwhile,
overexpression
able
through
with
promoter
region
activating
PI3K/Akt
signaling.
could
alleviate
painful
behavior
complete
Freund's
adjuvant
(CFA)
rats
modulating
STAT3/CCL5
axis
inhibiting
polarization.
conclusion,
CFA
via
regulating
Hence,
research
might
provide
novel
agent
treatment.
Язык: Английский