Developing a predictive model for blood-brain-barrier permeability to explore relevance of in vitro neurotoxicity data for in vivo risk assessment DOI Creative Commons

Siena Elizabeth Illa,

Yumei Feng Earley, Li M. Li

и другие.

Frontiers in Toxicology, Год журнала: 2025, Номер 7

Опубликована: Апрель 17, 2025

Despite recent rapid advancements in vitro toxicology, its application to whole-body health outcomes remains limited. Incorporating factors like internal exposure, such as permeability across biomembranes, could improve relevance. Notably, there is a lack of data and predictive models for blood-brain barrier (BBB) permeability, proxy the exposure target organs neurotoxicity. We developed model BBB investigate whether it can strengthen correlation between vivo neurotoxicity data. collected from parallel artificial membrane assays brain membranes (PAMPA-BBB) 106 compounds with varied physicochemical properties. This was utilized develop an empirical expand potential coverage chemicals. A list 23 chemicals available EPA IRIS ToxCast curated analyze toxicity rankings Spearman coefficient, without consideration our model. The PAMPA-BBB showed promising results, R2 0.71 (measured vs predicted permeabilities). Considering did not (0.01 -0.11). weak may stem uncertainty exclusion other toxicokinetic processes, along interspecies toxicodynamics differences. Our results indicate more detailed information on how neurotoxic substances behave inside body essential better utilize predicting assessing risk central nervous system.

Язык: Английский

Threading the Eye of the Needle: Designing the Next Generation of Crop Protection Solutions in an Increasingly Deglobalized Regulatory Landscape DOI

Reza J. Rasoulpour,

Ashish Batra,

Guomin Shan

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер 73(3), С. 1801 - 1803

Опубликована: Янв. 22, 2025

The growing global needs for food and feed the impact of climate change on agriculture demand innovative sustainable solutions to protect against crop losses improve yields worldwide. To facilitate timely discovery development new protection products with favorable human health environmental safety profiles, approach methodologies (NAMs) is essential predict potential risk perform assessment early in process. Significant advances NAM research have been made recent years. We organized a Virtual Special Issue invited submissions seven high-quality articles reviews latest emerging NAMs predictive agrochemical development. Here we provide an introductory overview need innovation novel agricultural highlight findings from each article this special edition.

Язык: Английский

Процитировано

0
Chemical risk assessment in food animals via physiologically based pharmacokinetic modeling – Part II: Environmental pollutants on animal and human health assessments DOI Creative Commons
Kun Mi, Zhoumeng Lin

Environment International, Год журнала: 2025, Номер unknown, С. 109372 - 109372

Опубликована: Март 1, 2025

Human activities generate a large amount of environmental pollutants, including drugs and agricultural industrial chemicals that are released into the air, water, soil. Environmental pollutants can enter food animals through contaminated feed posing risks to human health via chain. Physiologically based pharmacokinetic (PBPK) modeling is used predict target organ dosimetry informing risk assessment. However, there lack critical reviews concerning PBPK models for in last several years (2020-2024). This review part series focusing on applications inform safety assessments. Part I focused veterinary drugs. The present article II focuses chemicals, pesticides, polychlorinated biphenyls (PCBs), bisphenols, per- polyfluoroalkyl substances (PFAS). discusses existing challenges developing shares our perspectives future directions, combinations vitro vivo extrapolation (IVIVE), machine learning artificial intelligence, read-across approaches, quantitative pharmacodynamic enhance potential assessing safety.

Язык: Английский

Процитировано

0
Developing a predictive model for blood-brain-barrier permeability to explore relevance of in vitro neurotoxicity data for in vivo risk assessment DOI Creative Commons

Siena Elizabeth Illa,

Yumei Feng Earley, Li M. Li

и другие.

Frontiers in Toxicology, Год журнала: 2025, Номер 7

Опубликована: Апрель 17, 2025

Despite recent rapid advancements in vitro toxicology, its application to whole-body health outcomes remains limited. Incorporating factors like internal exposure, such as permeability across biomembranes, could improve relevance. Notably, there is a lack of data and predictive models for blood-brain barrier (BBB) permeability, proxy the exposure target organs neurotoxicity. We developed model BBB investigate whether it can strengthen correlation between vivo neurotoxicity data. collected from parallel artificial membrane assays brain membranes (PAMPA-BBB) 106 compounds with varied physicochemical properties. This was utilized develop an empirical expand potential coverage chemicals. A list 23 chemicals available EPA IRIS ToxCast curated analyze toxicity rankings Spearman coefficient, without consideration our model. The PAMPA-BBB showed promising results, R2 0.71 (measured vs predicted permeabilities). Considering did not (0.01 -0.11). weak may stem uncertainty exclusion other toxicokinetic processes, along interspecies toxicodynamics differences. Our results indicate more detailed information on how neurotoxic substances behave inside body essential better utilize predicting assessing risk central nervous system.

Язык: Английский

Процитировано

0