Threading the Eye of the Needle: Designing the Next Generation of Crop Protection Solutions in an Increasingly Deglobalized Regulatory Landscape
Reza J. Rasoulpour,
Ashish Batra,
Guomin Shan
и другие.
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
73(3), С. 1801 - 1803
Опубликована: Янв. 22, 2025
The
growing
global
needs
for
food
and
feed
the
impact
of
climate
change
on
agriculture
demand
innovative
sustainable
solutions
to
protect
against
crop
losses
improve
yields
worldwide.
To
facilitate
timely
discovery
development
new
protection
products
with
favorable
human
health
environmental
safety
profiles,
approach
methodologies
(NAMs)
is
essential
predict
potential
risk
perform
assessment
early
in
process.
Significant
advances
NAM
research
have
been
made
recent
years.
We
organized
a
Virtual
Special
Issue
invited
submissions
seven
high-quality
articles
reviews
latest
emerging
NAMs
predictive
agrochemical
development.
Here
we
provide
an
introductory
overview
need
innovation
novel
agricultural
highlight
findings
from
each
article
this
special
edition.
Язык: Английский
Chemical risk assessment in food animals via physiologically based pharmacokinetic modeling – Part II: Environmental pollutants on animal and human health assessments
Environment International,
Год журнала:
2025,
Номер
unknown, С. 109372 - 109372
Опубликована: Март 1, 2025
Human
activities
generate
a
large
amount
of
environmental
pollutants,
including
drugs
and
agricultural
industrial
chemicals
that
are
released
into
the
air,
water,
soil.
Environmental
pollutants
can
enter
food
animals
through
contaminated
feed
posing
risks
to
human
health
via
chain.
Physiologically
based
pharmacokinetic
(PBPK)
modeling
is
used
predict
target
organ
dosimetry
informing
risk
assessment.
However,
there
lack
critical
reviews
concerning
PBPK
models
for
in
last
several
years
(2020-2024).
This
review
part
series
focusing
on
applications
inform
safety
assessments.
Part
I
focused
veterinary
drugs.
The
present
article
II
focuses
chemicals,
pesticides,
polychlorinated
biphenyls
(PCBs),
bisphenols,
per-
polyfluoroalkyl
substances
(PFAS).
discusses
existing
challenges
developing
shares
our
perspectives
future
directions,
combinations
vitro
vivo
extrapolation
(IVIVE),
machine
learning
artificial
intelligence,
read-across
approaches,
quantitative
pharmacodynamic
enhance
potential
assessing
safety.
Язык: Английский
Developing a predictive model for blood-brain-barrier permeability to explore relevance of in vitro neurotoxicity data for in vivo risk assessment
Frontiers in Toxicology,
Год журнала:
2025,
Номер
7
Опубликована: Апрель 17, 2025
Despite
recent
rapid
advancements
in
vitro
toxicology,
its
application
to
whole-body
health
outcomes
remains
limited.
Incorporating
factors
like
internal
exposure,
such
as
permeability
across
biomembranes,
could
improve
relevance.
Notably,
there
is
a
lack
of
data
and
predictive
models
for
blood-brain
barrier
(BBB)
permeability,
proxy
the
exposure
target
organs
neurotoxicity.
We
developed
model
BBB
investigate
whether
it
can
strengthen
correlation
between
vivo
neurotoxicity
data.
collected
from
parallel
artificial
membrane
assays
brain
membranes
(PAMPA-BBB)
106
compounds
with
varied
physicochemical
properties.
This
was
utilized
develop
an
empirical
expand
potential
coverage
chemicals.
A
list
23
chemicals
available
EPA
IRIS
ToxCast
curated
analyze
toxicity
rankings
Spearman
coefficient,
without
consideration
our
model.
The
PAMPA-BBB
showed
promising
results,
R2
0.71
(measured
vs
predicted
permeabilities).
Considering
did
not
(0.01
-0.11).
weak
may
stem
uncertainty
exclusion
other
toxicokinetic
processes,
along
interspecies
toxicodynamics
differences.
Our
results
indicate
more
detailed
information
on
how
neurotoxic
substances
behave
inside
body
essential
better
utilize
predicting
assessing
risk
central
nervous
system.
Язык: Английский