Microplastic and the Enteric Nervous System: Effect of PET Microparticles on Selected Neurotransmitters and Cytokines in the Porcine Ileum DOI Open Access
Ismena Gałęcka, Jarosław Całka

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(21), С. 11645 - 11645

Опубликована: Окт. 30, 2024

Microplastic is an environmental hazard to which both animals and humans are exposed. Current reports show that it can cause inflammation, including in the gastrointestinal tract. To examine impact on ileum, 15 eight-week-old gilts (five individuals/group) were exposed PET microplastics (7.6 µm-416.9 µm) at a dose of 0.1 g/day or 1 for 28 days. The collected ileum fragments investigated cytokine concentrations (IL-1β, IL-6, IL-8, IL-10, TNF-α; ELISA test), neuron populations (cocaine amphetamine-regulated transcript, galanin, neuronal nitric oxide synthase, substance P, vesicular acetylcholine transporter, vasoactive intestinal peptide; immunofluorescence staining), morphometric parameters (histological analysis). Under influence MP-PET, there was reduction CART- GAL-positive neurons submucosal plexuses nNOS-, VAChT-, VIP-positive all plexuses. In contrast, increase myenteric plexus SP-positive IL-1β, TNF-α did not undergo statistically significant changes under low high MP-PET. histological structure exclusively concerned thinning mucosa muscularis externa. results support thesis MP-PET neutral ileal cells.

Язык: Английский

Toxicity Mechanisms of Microplastic and Its Effects on Ruminant Production: A Review DOI Creative Commons

Mao-Sen Su,

Shangquan Gan, Rui Gao

и другие.

Biomolecules, Год журнала: 2025, Номер 15(4), С. 462 - 462

Опубликована: Март 21, 2025

Plastic pollution has become one of the major environmental problems facing human beings in world today. waste accumulated environment forms plastic particles different sizes due to farming activities, climate change, ultraviolet light, microbial degradation, and animal chewing. The caused by microplastics a problem recent years, it is also research hotspot field ecological environment. More more studies have found that ruminants are exposed for long time, which seriously threaten their healthy growth. This paper introduces current situation pollution; properties effects on environment, beings, animals; summarizes types toxicity mechanisms microplastics; concludes main ways enter harm them. In addition, shortcomings future development summarized prospected provide theoretical reference related alleviating influence ruminant production.

Язык: Английский

Процитировано

0
Elevated Levels of Foreign Microparticles in the Blood of Patients with Digestive System Diseases DOI
Jie Song, Yunqing Wang,

Yunxia Ji

и другие.

Environmental Science & Technology Letters, Год журнала: 2025, Номер unknown

Опубликована: Апрель 14, 2025

Язык: Английский

Процитировано

0
Microplastic and the Enteric Nervous System: Effect of PET Microparticles on Selected Neurotransmitters and Cytokines in the Porcine Ileum DOI Open Access
Ismena Gałęcka, Jarosław Całka

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(21), С. 11645 - 11645

Опубликована: Окт. 30, 2024

Microplastic is an environmental hazard to which both animals and humans are exposed. Current reports show that it can cause inflammation, including in the gastrointestinal tract. To examine impact on ileum, 15 eight-week-old gilts (five individuals/group) were exposed PET microplastics (7.6 µm-416.9 µm) at a dose of 0.1 g/day or 1 for 28 days. The collected ileum fragments investigated cytokine concentrations (IL-1β, IL-6, IL-8, IL-10, TNF-α; ELISA test), neuron populations (cocaine amphetamine-regulated transcript, galanin, neuronal nitric oxide synthase, substance P, vesicular acetylcholine transporter, vasoactive intestinal peptide; immunofluorescence staining), morphometric parameters (histological analysis). Under influence MP-PET, there was reduction CART- GAL-positive neurons submucosal plexuses nNOS-, VAChT-, VIP-positive all plexuses. In contrast, increase myenteric plexus SP-positive IL-1β, TNF-α did not undergo statistically significant changes under low high MP-PET. histological structure exclusively concerned thinning mucosa muscularis externa. results support thesis MP-PET neutral ileal cells.

Язык: Английский

Процитировано

0