Bidirectional Interplay Among Non-Coding RNAs, the Microbiome, and the Host During Development and Diseases
Genes,
Год журнала:
2025,
Номер
16(2), С. 208 - 208
Опубликована: Фев. 8, 2025
It
is
widely
known
that
the
dysregulation
of
non-coding
RNAs
(ncRNAs)
and
dysbiosis
gut
microbiome
play
significant
roles
in
host
development
progression
various
diseases.
Emerging
evidence
has
highlighted
bidirectional
interplay
between
ncRNAs
microbiome.
This
article
aims
to
review
current
understanding
molecular
mechanisms
underlying
crosstalk
ncRNAs,
especially
microRNA
(miRNA),
context
diseases,
such
as
colorectal
cancer,
inflammatory
bowel
neurological
disorders,
obesity,
cardiovascular
disease.
Ultimately,
this
seeks
provide
a
foundation
for
exploring
potential
interactions
biomarkers
therapeutic
targets
clinical
diagnosis
treatment,
ncRNA
mimics,
antisense
oligonucleotides,
small-molecule
compounds,
well
probiotics,
prebiotics,
diets.
Язык: Английский
Flavonoids and the gut microbiome: a powerful duo for brain health
Critical Reviews in Food Science and Nutrition,
Год журнала:
2024,
Номер
unknown, С. 1 - 16
Опубликована: Дек. 4, 2024
Flavonoids,
a
class
of
polyphenolic
compounds,
are
widely
distributed
in
plant-based
foods
and
have
been
recognized
for
their
potential
to
promote
overall
health
well-being.
Flavonoids
fruits
vegetables
offer
various
beneficial
effects
such
as
anti-aging,
anticancer,
anti-inflammatory
properties.
extensively
studied
neuroprotective
properties,
which
attributed
ability
cross
the
blood-brain
barrier
interact
with
neural
cells.
Factors
like
gut
microbiota
composition,
age,
genetics,
diet
can
impact
how
well
flavonoids
absorbed
gut.
The
enhance
absorption
through
enzymatic
processes,
making
composition
key
factor
influenced
by
diet.
modulate
prebiotic
antimicrobial
effects,
affecting
production
microbial
metabolites
short-chain
fatty
acids
(SCFAs)
butyrate,
play
role
brain
function
health.
microbiome
also
modulates
immune
system,
is
critical
preventing
neuroinflammation.
Additionally,
benefit
mental
psychological
influencing
signaling
pathways
cells
increasing
tyrosine
tryptophan,
precursors
neurotransmitters
serotonin,
dopamine,
norepinephrine,
adrenaline,
gamma-aminobutyric
acid
(GABA).
flavonoid-gut
axis
complex
multifaceted
relationship
that
has
significant
implications
neurological
This
review
will
explore
genetic
environmental
factors
flavonoid
positive
on
network.
Язык: Английский
Lactobacillus plantarum 17-1 Ameliorates DSS-Induced Colitis by Modulating the Colonic Microbiota Composition and Metabolome in Mice
Nutrients,
Год журнала:
2025,
Номер
17(8), С. 1348 - 1348
Опубликована: Апрель 15, 2025
Background/Objectives:
Lactobacillus
strains
are
widely
used
as
probiotics
in
the
functional
food
industry
and
show
potential
for
treating
inflammatory
bowel
disease
(IBD).
However,
strain
specificity
limited
stress
resistance
of
restricts
its
therapeutic
effectiveness.
The
aim
this
study
was
to
investigate
effects
dietary
supplementation
with
microencapsulated
plantarum
17-1
on
intestinal
immune
responses,
gut
microbiota
composition,
metabolic
characteristics
colitis
mice.
Methods:
Mice
were
pre-fed
a
diet
containing
3
weeks
then
treated
2.5%
dextran
sulfate
sodium
(DSS)
drinking
water
8
days
induce
colitis.
Results:
results
showed
that
effectively
alleviated
clinical
symptoms
histopathological
features
mice
suppressed
up-regulation
pro-inflammatory
cytokines
IL-6
IL-17
colon
Additionally,
significantly
increased
relative
abundance
several
beneficial
bacterial
taxa,
including
Ruminococcaceae_UCG_014,
Bacteroides,
Prevotellaceae_UCG_001,
Lactococcus,
Weissella,
Pediococcus,
so
on.
Moreover,
it
regulated
levels
multiple
inflammation-related
metabolites
involved
linolenic
acid
metabolism,
arachidonic
primary
bile
biosynthesis,
tyrosine
metabolism.
Conclusions:
These
suggest
reduced
inflammation
by
modulating
composition
characteristics,
which
may
serve
strategy
IBD.
Язык: Английский