Pyrroloquinoline-quinone supplementation restores ovarian function and oocyte quality in a mouse model of advanced maternal age DOI
Kemei Zhang, Rui Xu, Jinzhao Ma

и другие.

Biology of Reproduction, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 23, 2024

Abstract Natural ovarian aging is one of the major causes for declining fertility in female animals, which has become an insurmountable issue human reproduction clinics and assisted reproductive technology procedures. Nevertheless, molecular basis oocyte remains poorly understood, feasible improvement strategies are unavailable. In present study, vivo supplementation pyrroloquinoline-quinone effectively elevated fecundity reproductively aged mice by balancing hormonal secretion, harmonizing estrus cycle, eliminating fibrosis. Moreover, quality also increased after administration from various aspects, including nuclear cytoplasmic maturation competency, fertilization capacity, pre-implantation embryonic development potential. Transcriptomic analysis identified target pathways that might mediate pyrroloquinoline-quinone’s effects oocytes. Specifically, it was demonstrated restored mitochondrial dynamics lysosomal function to remove excessive reactive oxygen species suppress apoptosis Jointly, these findings demonstrate efficacious method restore compromised ovary damaged mice, be a potential clinical therapy women advanced maternal age with infertility.

Язык: Английский

Radiation exposure induced blood-brain barrier injury via mitochondria-mediated sterile inflammation DOI Open Access
Peng Wang, Jiayue Liu, Min Zhang

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 6, 2025

Abstract Radiation-induced brain injury (RIBI) is caused by exposure to high doses of ionizing radiation and characterized severe cognitive dysfunction necrosis. The widespread application radiotherapy rapid development deep space exploration have substantially increased the risk RIBI. However, pathogenesis RIBI not fully understood, no effective intervention available. This work described a blood-brain barrier (BBB) microphysiological system (MPS), that allowed explore responses BBB distinct cells exposure. MPS can recapitulate interface structure function in microenvironment, including endothelial cells, astrocytes, pericytes microglia co-cultured under flow condition. Following acute X-ray or γ-ray, characteristic RIBI-associated pathological were observed, compromise, DNA breaks, inhibited cell proliferation, hypertrophy pro-inflammatory cytokine release. Among distinctive types showed highest radiosensitivity as compared other MPS. Intriguingly, γ-ray consistently induced prominent sterile inflammation responses, especially type I interferon response, These mediated radiation-induced mitochondrial release subsequent activation cGAS-STING signaling pathway. Furthermore, we found abrocitinib (JAK1 inhibitor) idebenone (mitochondrial protectant) attenuate ameliorate injury. findings revealed involvement mitochondria-mediated pathogenesis, identifying mitochondria potential target for new radioprotective measures.

Язык: Английский

Процитировано

0
Current study on Pyrroloquinoline quinone (PQQ) therapeutic role in neurodegenerative diseases DOI
Tao Xie, Libin Chen,

Mingzhe Feng

и другие.

Molecular Biology Reports, Год журнала: 2025, Номер 52(1)

Опубликована: Апрель 15, 2025

Язык: Английский

Процитировано

0
Targeting mitochondria: restoring the antitumor efficacy of exhausted T cells DOI Creative Commons

Meiqi Yang,

Shuling Zhang,

Li Sun

и другие.

Molecular Cancer, Год журнала: 2024, Номер 23(1)

Опубликована: Ноя. 19, 2024

Immune checkpoint blockade therapy has revolutionized cancer treatment, but resistance remains prevalent, often due to dysfunctional tumor-infiltrating lymphocytes. A key contributor this dysfunction is mitochondrial dysfunction, characterized by defective oxidative phosphorylation, impaired adaptation, and depolarization, which promotes T cell exhaustion severely compromises antitumor efficacy. This review summarizes recent advances in restoring the function of exhausted cells through mitochondria-targeted strategies, such as metabolic remodeling, enhanced biogenesis, regulation antioxidant reactive oxygen species, with aim reversing state improving response immunotherapy. deeper understanding role mitochondria lays foundation for development novel therapies opens a new chapter

Язык: Английский

Процитировано

2
Pyrroloquinoline-quinone supplementation restores ovarian function and oocyte quality in a mouse model of advanced maternal age DOI
Kemei Zhang, Rui Xu, Jinzhao Ma

и другие.

Biology of Reproduction, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 23, 2024

Abstract Natural ovarian aging is one of the major causes for declining fertility in female animals, which has become an insurmountable issue human reproduction clinics and assisted reproductive technology procedures. Nevertheless, molecular basis oocyte remains poorly understood, feasible improvement strategies are unavailable. In present study, vivo supplementation pyrroloquinoline-quinone effectively elevated fecundity reproductively aged mice by balancing hormonal secretion, harmonizing estrus cycle, eliminating fibrosis. Moreover, quality also increased after administration from various aspects, including nuclear cytoplasmic maturation competency, fertilization capacity, pre-implantation embryonic development potential. Transcriptomic analysis identified target pathways that might mediate pyrroloquinoline-quinone’s effects oocytes. Specifically, it was demonstrated restored mitochondrial dynamics lysosomal function to remove excessive reactive oxygen species suppress apoptosis Jointly, these findings demonstrate efficacious method restore compromised ovary damaged mice, be a potential clinical therapy women advanced maternal age with infertility.

Язык: Английский

Процитировано

0