Design, synthesis, antifungal evaluation and mechanism study of myrtenal derivatives as potential laccase inhibitors DOI
Yiming Zheng,

Zhennan Cui,

Yunzhuo Wu

и другие.

Pest Management Science, Год журнала: 2025, Номер unknown

Опубликована: Май 15, 2025

Abstract BACKGROUND To develop novel natural product‐derived fungicides, four series of myrtenal oxadiazole/thiadiazole‐hydrazide/amide derivatives were designed, synthesized and evaluated for their inhibitions toward several crop pathogenic fungi/oomycetes. RESULTS In the in vitro antifungal experiments, some showed good activity against Botryosphaeria dothidea, Sclerotinia sclerotiorum Fusarium graminearum . Among them, compound 6d exhibited best B. dothidea , with EC 50 value 0.052 mg/L, which was significantly stronger than carbendazim (EC = 0.40 mg/L). vivo assay on apple fruits branches that displayed significant protective curative effects, both superior to carbendazim. preliminary mechanism study, can damage surface morphology mycelia, destroy integrity permeability cell membrane, increase intracellular ROS content, thereby inhibiting growth Compound also inhibited laccase IC 8.45 μM, much cysteine PMDD‐5Y. Molecular docking confirmed binding affinity interaction mode laccase. CONCLUSION This study presented a promising lead inhibitors as fungicidal agrochemicals, demonstrated anti‐ inhibitory activity. © 2025 Society Chemical Industry.

Язык: Английский

Synthesis of L-carvone-derived imidazo[1,2-a]pyrimidine / nano sodium alginate complexes with significant antifungal activity and sustained releasing performance DOI
Zhaolei Zhang, Baoyu Li,

Wengui Duan

и другие.

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 141823 - 141823

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Thiourea Derivatives in Agrochemical Discovery and Development DOI
Yi Qi, Ping Sun, Xinyi Zhang

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

Thiourea, represented by the chemical formula (R1R2N)(R3R4N)C═S, is a significant organic sulfur compound characterized presence of atom and two amino groups. Meanwhile, thiourea isothiourea are reciprocal isomers. This structure facilitates formation biologically active moiety, which interconnected through double bonds between nitrogen atoms. As potent component in pesticide formulations, demonstrates efficacy safeguarding crops against variety diseases inhibiting growth reproduction pathogens. review aims to provide comprehensive summary derivatives exhibiting fungicidal, insecticidal, antiviral, herbicidal, plant regulatory properties, with objective offering new perspectives for identifying innovative thiourea-based pesticides elucidating their mechanisms action.

Язык: Английский

Процитировано

0
Design, synthesis, antifungal evaluation and mechanism study of myrtenal derivatives as potential laccase inhibitors DOI
Yiming Zheng,

Zhennan Cui,

Yunzhuo Wu

и другие.

Pest Management Science, Год журнала: 2025, Номер unknown

Опубликована: Май 15, 2025

Abstract BACKGROUND To develop novel natural product‐derived fungicides, four series of myrtenal oxadiazole/thiadiazole‐hydrazide/amide derivatives were designed, synthesized and evaluated for their inhibitions toward several crop pathogenic fungi/oomycetes. RESULTS In the in vitro antifungal experiments, some showed good activity against Botryosphaeria dothidea, Sclerotinia sclerotiorum Fusarium graminearum . Among them, compound 6d exhibited best B. dothidea , with EC 50 value 0.052 mg/L, which was significantly stronger than carbendazim (EC = 0.40 mg/L). vivo assay on apple fruits branches that displayed significant protective curative effects, both superior to carbendazim. preliminary mechanism study, can damage surface morphology mycelia, destroy integrity permeability cell membrane, increase intracellular ROS content, thereby inhibiting growth Compound also inhibited laccase IC 8.45 μM, much cysteine PMDD‐5Y. Molecular docking confirmed binding affinity interaction mode laccase. CONCLUSION This study presented a promising lead inhibitors as fungicidal agrochemicals, demonstrated anti‐ inhibitory activity. © 2025 Society Chemical Industry.

Язык: Английский

Процитировано

0