Diverse abietane diterpenoids as multifunctional antimicrobial effects from Salvia castanea DOI
Panpan Wang, Song Gao,

Shu‐Xia Liu

и другие.

Pest Management Science, Год журнала: 2025, Номер unknown

Опубликована: Май 7, 2025

Abstract BACKGROUND Phytopathogenic fungal diseases significantly impact the quality of vegetables and fruits in agriculture. Salvia castanea , a Tibetan medicinal plant, possessed anti‐inflammatory, antitumor, antimicrobial activities. Therefore, we investigated ingredients from this plant clarified their protective curative plants detail. RESULTS Bio‐guided isolation was conducted to obtain 23 abietane diterpenoids, including three new ones (Castanoids A–C). Most compounds exhibited significant antifungal activity against four fungi. Castanoid C ( 7 ) showed remarkable inhibition Sclerotinia sclerotiorum Valsa mali Botrytis cinerea with median effective concentration (EC 50 values 1.30, 0.84, 2.40 μg/mL, respectively, outperforming commercial agent trifloxystrobin. In vivo compound demonstrated 100% 82.26 ± 1.07% efficiency on rape leaves at 200 μg/mL. At 300 μg/ mL, it effectively controlled tomato rot 92.65 2.55% activity. The observation by transmission electron microscopy disclosed that inhibited growth fungi destroying cell membrane permeability caused leakage cellular components. Additionally, 11 exerted potent inhibitory effects Staphylococcus aureus Pseudomonas syringae pv. actinidae (Psa) minimum (MIC) value 6.25 μ m surpassing gentamicin. Its mechanism Psa may also involve damage. CONCLUSION result highlights antibacterial potential diterpenoids particularly C. These findings suggest broad applicability agriculture, especially for controlling rape, apple, crops. This research provides foundation developing natural, agents, advancing field disease management. © 2025 Society Chemical Industry.

Язык: Английский

Isoflavones and Stilbenes With Antifungal Activities From the Seeds of Thermopsis lanceolata R. Br DOI

Cheng-Feng Liu,

Jianguo Tan,

Xuye Wu

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 30, 2025

In order to discover novel fungicides from natural products, the phytochemical investigation of Thermopsis lanceolata seeds was thoroughly conducted. Eight new isoflavone derivatives (1-5 and 8-10), two stilbenes (6 7), as well 21 known isoflavones (11-31) were obtained crude extract T. following a bioassay-guided method. The structures 1-31 confirmed via HRESIMS, NMR, IR, UV, quantum chemistry calculations. antifungal activities against Phytophthora nicotiana, Colletotrichum orbiculare, Rhizoctonia solani, Botrytis cinerea screened according mycelial inhibition test. Compound 6 displayed significant activity B. in vitro (EC50: 9.68 μg/mL) had an 8 5.7% prevention control effect vivo (100 μg/mL). Moreover, mechanism studies revealed that causes accumulation reactive oxygen species, increases level lipid peroxidation, decreases MDH, finally triggers molecular damage cell death vitro. Therefore, can be utilized lead compound for fungicides.

Язык: Английский

Процитировано

0
Diverse abietane diterpenoids as multifunctional antimicrobial effects from Salvia castanea DOI
Panpan Wang, Song Gao,

Shu‐Xia Liu

и другие.

Pest Management Science, Год журнала: 2025, Номер unknown

Опубликована: Май 7, 2025

Abstract BACKGROUND Phytopathogenic fungal diseases significantly impact the quality of vegetables and fruits in agriculture. Salvia castanea , a Tibetan medicinal plant, possessed anti‐inflammatory, antitumor, antimicrobial activities. Therefore, we investigated ingredients from this plant clarified their protective curative plants detail. RESULTS Bio‐guided isolation was conducted to obtain 23 abietane diterpenoids, including three new ones (Castanoids A–C). Most compounds exhibited significant antifungal activity against four fungi. Castanoid C ( 7 ) showed remarkable inhibition Sclerotinia sclerotiorum Valsa mali Botrytis cinerea with median effective concentration (EC 50 values 1.30, 0.84, 2.40 μg/mL, respectively, outperforming commercial agent trifloxystrobin. In vivo compound demonstrated 100% 82.26 ± 1.07% efficiency on rape leaves at 200 μg/mL. At 300 μg/ mL, it effectively controlled tomato rot 92.65 2.55% activity. The observation by transmission electron microscopy disclosed that inhibited growth fungi destroying cell membrane permeability caused leakage cellular components. Additionally, 11 exerted potent inhibitory effects Staphylococcus aureus Pseudomonas syringae pv. actinidae (Psa) minimum (MIC) value 6.25 μ m surpassing gentamicin. Its mechanism Psa may also involve damage. CONCLUSION result highlights antibacterial potential diterpenoids particularly C. These findings suggest broad applicability agriculture, especially for controlling rape, apple, crops. This research provides foundation developing natural, agents, advancing field disease management. © 2025 Society Chemical Industry.

Язык: Английский

Процитировано

0