Novel Furazanoazepines Derivatives as Sdh Inhibitors: Design, Synthesis and Their Fungicidal Activities

Опубликована: Янв. 1, 2025

Plant diseases induced by plant pathogenic fungi are the damage caused of agriculture and food losses. The development novel fungicides is an urgent way to deal with increasing resistance environmental issues. Herein, 37 furazanoazepines derivatives were effectively synthesized their antifungal activity was investigated against four phytopathogenic fungi. result indicated that compound 4h exhibited excellent Alternaria alternata (EC50 = 17.267 μg/mL), which obviously better than positive control osthole. In addition, scanning electron microscopy (SEM) showed could cause morphological hyphae. To understand its action mode, molecular docking performed on succinate dehydrogenase (SDH). results amide bond form a hydrogen interaction Gly128 residue.The 3D-QSAR conducted reveal structure-activity relationship prepared compounds. SDH enzymatic testing revealed inhibitory effect IC50 values 3.59 μg/mL, control. It concluded in this study promising for further explore potential agricultural fungicides.

Язык: Английский

Novel furazanoazepines derivatives as SDH inhibitors: Design, synthesis and their fungicidal activities

Bioorganic Chemistry, Год журнала: 2025, Номер 157, С. 108244 - 108244

Опубликована: Фев. 4, 2025

Язык: Английский