Design, Synthesis, Antifungal Evaluation, and Action Mechanism of Novel l-Carvone-Based Derivatives as Potential Succinate Dehydrogenase Inhibitors DOI
Hongyi Chen,

Zunyun Jiang,

Ziyun Mai

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

Natural products serve as a crucial source of compounds for developing novel agricultural antifungals. In this work, we utilized the natural product l-carvone molecular scaffold to design and synthesize three series l-carvone-based derivatives. The in vitro bioassay results indicated that most target exhibited remarkable antifungal activity. Notably, compound C3 demonstrated broad-spectrum activity against Rhizoctonia solani, Botrytis cinerea, Sclerotinia sclerotiorum, Gibberella zeae, Valsa mali, with EC50 values 0.274, 0.985, 4.17, 5.71, 2.29 μg/mL, respectively. vivo preventative efficacies C11 R. solani C13 B. cinerea revealed they had potential mechanism study, cell membrane permeability experiment showed significantly increased membrane, microscopic observations could destroy structural integrity cells reduce number mitochondria, thus affecting normal growth mycelia. Furthermore, mitochondrial detection, succinate dehydrogenase (SDH) enzyme assay, dynamics (MD) simulations, docking experiments further action binding mode SDH may be similar those thifluzamide. abovementioned provided valuable reference discovery inhibitor fungicides.

Язык: Английский

Design, Synthesis, Antifungal Evaluation, and Action Mechanism of Novel l-Carvone-Based Derivatives as Potential Succinate Dehydrogenase Inhibitors DOI
Hongyi Chen,

Zunyun Jiang,

Ziyun Mai

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

Natural products serve as a crucial source of compounds for developing novel agricultural antifungals. In this work, we utilized the natural product l-carvone molecular scaffold to design and synthesize three series l-carvone-based derivatives. The in vitro bioassay results indicated that most target exhibited remarkable antifungal activity. Notably, compound C3 demonstrated broad-spectrum activity against Rhizoctonia solani, Botrytis cinerea, Sclerotinia sclerotiorum, Gibberella zeae, Valsa mali, with EC50 values 0.274, 0.985, 4.17, 5.71, 2.29 μg/mL, respectively. vivo preventative efficacies C11 R. solani C13 B. cinerea revealed they had potential mechanism study, cell membrane permeability experiment showed significantly increased membrane, microscopic observations could destroy structural integrity cells reduce number mitochondria, thus affecting normal growth mycelia. Furthermore, mitochondrial detection, succinate dehydrogenase (SDH) enzyme assay, dynamics (MD) simulations, docking experiments further action binding mode SDH may be similar those thifluzamide. abovementioned provided valuable reference discovery inhibitor fungicides.

Язык: Английский

Процитировано

0