Evaluation of natural l‐phenylalanine‐derived Amidohydrazide derivatives in ensuring agriculture production against phytopathogenic fungi† DOI
Tiancheng Zhang, Hong‐Bin Fang, Yongwei Gong

и другие.

Pest Management Science, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

Abstract BACKGROUND Ensuring food security is fundamental to national and an important guarantee for global peace development. The use of fungicides represents effective strategy in safeguarding sufficient supply against phytopathogenic fungi; however, given the escalating pathogen resistance, there urgent need develop new, highly efficient, environmentally friendly green fungicides. RESULTS In this study, 24 novel amidohydrazide derivatives were designed synthesized by incorporating bioactive amide hydrazide groups into natural l ‐phenylalanine. bioassays revealed that certain compounds exhibited remarkable inhibitory activity agricultural pathogenic fungi, with compound A21 particularly displaying exceptional vitro vivo fungicidal Rhizoctonia solani . Scanning electron microscopy (SEM) transmission (TEM) observations showed treatment induced significant morphological changes R. mycelia, including cell membrane contraction. Transcriptomic analysis indicated differentially expressed genes (DEGs) treated significantly enriched pathways related carbohydrate metabolism lipid metabolism, relative expression representative DEGs was further validated quantitative real‐time polymerase chain reaction (qRT‐PCR). increase ergosterol content suggested may counteract drug stress enhancing biosynthesis. Toxic assessment demonstrated zebrafish exposed had survival rates 90% at 1 μg mL −1 60% 10 within 72 h. Additionally, hydrolysis behavior different pH buffers these displayed rapid 9.18 buffer, while maintaining relatively high stability 4.01 6.86 buffers. CONCLUSION Amidohydrazide have excellent efficacy hold great promise as a pharmacophore development new fungicides, thereby ensuring security. © 2025 Society Chemical Industry.

Язык: Английский

Evaluation of natural l‐phenylalanine‐derived Amidohydrazide derivatives in ensuring agriculture production against phytopathogenic fungi† DOI
Tiancheng Zhang, Hong‐Bin Fang, Yongwei Gong

и другие.

Pest Management Science, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

Abstract BACKGROUND Ensuring food security is fundamental to national and an important guarantee for global peace development. The use of fungicides represents effective strategy in safeguarding sufficient supply against phytopathogenic fungi; however, given the escalating pathogen resistance, there urgent need develop new, highly efficient, environmentally friendly green fungicides. RESULTS In this study, 24 novel amidohydrazide derivatives were designed synthesized by incorporating bioactive amide hydrazide groups into natural l ‐phenylalanine. bioassays revealed that certain compounds exhibited remarkable inhibitory activity agricultural pathogenic fungi, with compound A21 particularly displaying exceptional vitro vivo fungicidal Rhizoctonia solani . Scanning electron microscopy (SEM) transmission (TEM) observations showed treatment induced significant morphological changes R. mycelia, including cell membrane contraction. Transcriptomic analysis indicated differentially expressed genes (DEGs) treated significantly enriched pathways related carbohydrate metabolism lipid metabolism, relative expression representative DEGs was further validated quantitative real‐time polymerase chain reaction (qRT‐PCR). increase ergosterol content suggested may counteract drug stress enhancing biosynthesis. Toxic assessment demonstrated zebrafish exposed had survival rates 90% at 1 μg mL −1 60% 10 within 72 h. Additionally, hydrolysis behavior different pH buffers these displayed rapid 9.18 buffer, while maintaining relatively high stability 4.01 6.86 buffers. CONCLUSION Amidohydrazide have excellent efficacy hold great promise as a pharmacophore development new fungicides, thereby ensuring security. © 2025 Society Chemical Industry.

Язык: Английский

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