Synbiotic Combination of Lactiplantibacillus plantarum and Fructo-Oligosaccharide Alleviates Soy Protein-Induced Food Allergies in Mice by Modulating the Gut Microbiota and Its Metabolisms DOI
Jing Bai, Qian Zeng,

Y. M. Ni

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Июнь 2, 2025

Oral administration of synbiotics is a highly effective approach to improve food allergies through the modulation gut microbiota. Therefore, effects composed Lactiplantibacillus plantarum (Lp) and fructo-oligosaccharide (FOS) on soybean-sensitized mice were explored in this study focusing microbiota metabolisms. The results indicated that Lp-FOS intervention significantly alleviated allergic symptoms, reduced IgE, IgG1, mMCP-1 levels, restored balance Th1/Th2 Tregs/Th17, enhanced intestinal barrier integrity. 16S rDNA microbiome sequencing revealed increased Lachnospiraceae Lactobacillus proportions Desulfovibrionaceae Muribaculaceae proportions. Nontargeted metabolomics further demonstrated improved metabolic disorders by modulating key pathways involved amino acid metabolism, cofactor vitamin lipid with notable enhancement tryptophan metabolism. Collectively, confirmed could mitigate soybean allergy regulating immune system, microbiota, pathway. This will offer novel insights into developing synbiotic-based interventions against allergies.

Язык: Английский

Sea buckthorn leaves and gallic acid inhibit C48/80-induced pseudo-allergic reaction via the PLC/IP3 signaling pathway both in vitro and in vivo DOI
Xianghua Zhang, Zhiwei Wang, Yue Li

и другие.

International Immunopharmacology, Год журнала: 2025, Номер 154, С. 114563 - 114563

Опубликована: Апрель 2, 2025

Язык: Английский

Процитировано

1
Di(2-ethylhexyl) Phthalate (DEHP) Exacerbates Food Allergy via Intestinal Barrier Dysfunction and Enhancing Allergic Sensitization DOI

Yuting Fan,

Zhoujin Xu,

Zhencong Yang

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 21, 2025

Di(2-ethylhexyl) phthalate (DEHP), a ubiquitous plasticizer, has raised concerns due to its potential role in exacerbating food allergy through chronic human exposure. The study aimed investigate the effects of DEHP on ovalbumin (OVA)-induced and elucidate underlying mechanisms related intestinal barrier homeostasis. In OVA-sensitized BALB/c mice, exposure significantly exacerbated allergic responses by functioning as an immunoadjuvant, evidenced heightened anaphylactic symptoms, elevated serum levels inflammatory mediators (IgE, IgG, IgG1, IgG2), increased concentrations histamine monocyte chemoattractant protein-1 (MCP-1). Furthermore, disrupted integrity impaired mucin secretion. Administration high-dose downregulated expression tight junction proteins mucins. Histopathological analysis revealed goblet cell depletion diminished production. results suggest that multifactorial mechanism involving dysfunction immune dysregulation. This establishes critical association between oral pathogenesis, providing insights into interplay environmental pollutants, immunity, manifestation.

Язык: Английский

Процитировано

0
Synbiotic Combination of Lactiplantibacillus plantarum and Fructo-Oligosaccharide Alleviates Soy Protein-Induced Food Allergies in Mice by Modulating the Gut Microbiota and Its Metabolisms DOI
Jing Bai, Qian Zeng,

Y. M. Ni

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Июнь 2, 2025

Oral administration of synbiotics is a highly effective approach to improve food allergies through the modulation gut microbiota. Therefore, effects composed Lactiplantibacillus plantarum (Lp) and fructo-oligosaccharide (FOS) on soybean-sensitized mice were explored in this study focusing microbiota metabolisms. The results indicated that Lp-FOS intervention significantly alleviated allergic symptoms, reduced IgE, IgG1, mMCP-1 levels, restored balance Th1/Th2 Tregs/Th17, enhanced intestinal barrier integrity. 16S rDNA microbiome sequencing revealed increased Lachnospiraceae Lactobacillus proportions Desulfovibrionaceae Muribaculaceae proportions. Nontargeted metabolomics further demonstrated improved metabolic disorders by modulating key pathways involved amino acid metabolism, cofactor vitamin lipid with notable enhancement tryptophan metabolism. Collectively, confirmed could mitigate soybean allergy regulating immune system, microbiota, pathway. This will offer novel insights into developing synbiotic-based interventions against allergies.

Язык: Английский

Процитировано

0