A New Insight into the Mechanism of Atrazine-Induced Neurotoxicity: Triggering Neural Stem Cell Senescence by Activating Integrated Stress Response Pathway DOI Creative Commons
Jian Chen, Xueyan Dai, Kanwar Kumar Malhi

и другие.

Research, Год журнала: 2024, Номер 7

Опубликована: Янв. 1, 2024

Atrazine (AT), a widely utilized chemical herbicide, causes widespread contamination of agricultural water bodies. Recently, exposure to AT has been linked the development age-related neurodegenerative diseases (NDs), suggesting its neurotoxicity potential. As an endocrine disruptor, targets hypothalamus, crucial part neuroendocrine system. However, toxicological mechanism hypothalamus and correlation with ND remain unexplored. Our results indicated that caused significant morphological structural damage leading loss mature intact neurons microglial activation. Furthermore, hypothalamic neural stem cells (HtNSCs) were recruited areas neuronal by AT. Through in vivo vitro experiments, we clarified outcomes AT-induced HtNSC recruitment alongside mature/intact neurons. Mechanistically, induces senescence these HtNSCs activating integrated stress response signaling. This consequently hinders repair damaged inhibiting proliferation differentiation. Overall, our findings underscore pivotal role pathway damage. Additionally, present study offers novel perspectives understand mechanisms provides preliminary evidence linking NDs.

Язык: Английский

A New Insight into the Mechanism of Atrazine-Induced Neurotoxicity: Triggering Neural Stem Cell Senescence by Activating Integrated Stress Response Pathway DOI Creative Commons
Jian Chen, Xueyan Dai, Kanwar Kumar Malhi

и другие.

Research, Год журнала: 2024, Номер 7

Опубликована: Янв. 1, 2024

Atrazine (AT), a widely utilized chemical herbicide, causes widespread contamination of agricultural water bodies. Recently, exposure to AT has been linked the development age-related neurodegenerative diseases (NDs), suggesting its neurotoxicity potential. As an endocrine disruptor, targets hypothalamus, crucial part neuroendocrine system. However, toxicological mechanism hypothalamus and correlation with ND remain unexplored. Our results indicated that caused significant morphological structural damage leading loss mature intact neurons microglial activation. Furthermore, hypothalamic neural stem cells (HtNSCs) were recruited areas neuronal by AT. Through in vivo vitro experiments, we clarified outcomes AT-induced HtNSC recruitment alongside mature/intact neurons. Mechanistically, induces senescence these HtNSCs activating integrated stress response signaling. This consequently hinders repair damaged inhibiting proliferation differentiation. Overall, our findings underscore pivotal role pathway damage. Additionally, present study offers novel perspectives understand mechanisms provides preliminary evidence linking NDs.

Язык: Английский

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