Biomonitoring PhIP, a Potential Prostatic Carcinogen, in the Hair of Healthy Men of African and European Ancestry DOI Creative Commons
Robert J. Turesky,

Clarence F. Jones,

Jingshu Guo

и другие.

Toxics, Год журнала: 2025, Номер 13(1), С. 42 - 42

Опубликована: Янв. 8, 2025

Heterocyclic aromatic amines (HAAs), formed during the cooking of meat, are potential human carcinogens, underscoring need for long-lived biomarkers to assess exposure and cancer risk. Frequent consumption well-done meats containing 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a prevalent HAA that is prostatic carcinogen in rodents DNA-damaging agent prostate cells, has been linked aggressive (PC) pathology. African American (AA) men face nearly twice risk developing dying from PC compared White men. We previously demonstrated scalp hair reliable biospecimen measuring PhIP intake using liquid chromatography-mass spectrometry. This study aimed determine whether dietary higher AA men, potentially contributing this health disparity. Healthy were found have significantly mean level (2.12-fold) than on free-choice diets. However, difference was not statistically significant after adjusting melanin content. Further research needed understand how pigmentation, follicular density, other morphological features influence accumulation. These insights can improve accuracy levels as biomarker its associations with

Язык: Английский

Biomonitoring PhIP, a Potential Prostatic Carcinogen, in the Hair of Healthy Men of African and European Ancestry DOI Creative Commons
Robert J. Turesky,

Clarence F. Jones,

Jingshu Guo

и другие.

Toxics, Год журнала: 2025, Номер 13(1), С. 42 - 42

Опубликована: Янв. 8, 2025

Heterocyclic aromatic amines (HAAs), formed during the cooking of meat, are potential human carcinogens, underscoring need for long-lived biomarkers to assess exposure and cancer risk. Frequent consumption well-done meats containing 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a prevalent HAA that is prostatic carcinogen in rodents DNA-damaging agent prostate cells, has been linked aggressive (PC) pathology. African American (AA) men face nearly twice risk developing dying from PC compared White men. We previously demonstrated scalp hair reliable biospecimen measuring PhIP intake using liquid chromatography-mass spectrometry. This study aimed determine whether dietary higher AA men, potentially contributing this health disparity. Healthy were found have significantly mean level (2.12-fold) than on free-choice diets. However, difference was not statistically significant after adjusting melanin content. Further research needed understand how pigmentation, follicular density, other morphological features influence accumulation. These insights can improve accuracy levels as biomarker its associations with

Язык: Английский

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