From De Novo Conceived Small Molecules to Multifunctional Supramolecular Nanoparticles: Dual Biofilm and T3SS Intervention, Enhanced Foliar Affinity, and Effective Rice Disease Control DOI Creative Commons

Xianfu Mu,

Kongjun Liu, Jinghan Yang

и другие.

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Март 27, 2025

Abstract Conventional antimicrobials typically exhibit suboptimal deposition on rice leaves, resulting in poor efficacy, further impaired by biofilms and Type III Secretion Systems (T3SS). Herein, this study presents a supramolecular strategy to fabricate BtP27@ β ‐CD, sunflower‐like material engineered through host‐guest recognition between de novo designed molecule BtP27 ‐cyclodextrin. ‐CD manifests enhanced foliar affinity vivo efficiency, demonstrating superior protective (62.67%) curative (51.16%) activities against bacterial leaf blight at low‐dose of 200 µg mL −1 compared commercial thiodiazole‐copper (37.78%/38.13%) without compromising safety. This multifunctional material, structurally derived from dufulin, inherit progenitor's systemic conductive properties, alongside the capacity activate salicylic acid‐mediated plant defense pathways. Moreover, it is endowed with anticipated abilities disorganize biofilm barriers, annihilate encased pathogens, inhibit T3SS. constitutes inaugural report supramolecular‐based biofilm/T3SS dual inhibitor. An expanded investigation into substrate indication screening identified additional molecules that self‐assemble ‐cyclodextrin form materials, exhibiting potency other diseases, ranging 63.53% 73.30% efficacy spanning 42.18% 60.41% . In brief, work establishes paradigm for designing guest scratch construct materials tailored characteristics.

Язык: Английский

From De Novo Conceived Small Molecules to Multifunctional Supramolecular Nanoparticles: Dual Biofilm and T3SS Intervention, Enhanced Foliar Affinity, and Effective Rice Disease Control DOI Creative Commons

Xianfu Mu,

Kongjun Liu, Jinghan Yang

и другие.

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Март 27, 2025

Abstract Conventional antimicrobials typically exhibit suboptimal deposition on rice leaves, resulting in poor efficacy, further impaired by biofilms and Type III Secretion Systems (T3SS). Herein, this study presents a supramolecular strategy to fabricate BtP27@ β ‐CD, sunflower‐like material engineered through host‐guest recognition between de novo designed molecule BtP27 ‐cyclodextrin. ‐CD manifests enhanced foliar affinity vivo efficiency, demonstrating superior protective (62.67%) curative (51.16%) activities against bacterial leaf blight at low‐dose of 200 µg mL −1 compared commercial thiodiazole‐copper (37.78%/38.13%) without compromising safety. This multifunctional material, structurally derived from dufulin, inherit progenitor's systemic conductive properties, alongside the capacity activate salicylic acid‐mediated plant defense pathways. Moreover, it is endowed with anticipated abilities disorganize biofilm barriers, annihilate encased pathogens, inhibit T3SS. constitutes inaugural report supramolecular‐based biofilm/T3SS dual inhibitor. An expanded investigation into substrate indication screening identified additional molecules that self‐assemble ‐cyclodextrin form materials, exhibiting potency other diseases, ranging 63.53% 73.30% efficacy spanning 42.18% 60.41% . In brief, work establishes paradigm for designing guest scratch construct materials tailored characteristics.

Язык: Английский

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