Novel 2,5‐dihydro‐3H‐[1,2,4]triazino[5,6‐b]indole derivatives decorated with disulfide moiety are effective for treating bacterial infections by inducing reactive oxygen species DOI
Guoqing Wang,

Hong‐Wu Liu,

Ya Zhou

и другие.

Pest Management Science, Год журнала: 2025, Номер unknown

Опубликована: Май 14, 2025

Abstract BACKGROUND Infectious diseases caused by pathogenic bacteria are the main causes of death in humans, and responsible for reduced yield quality quantity plants globally. This underscores need developing bactericide alternatives with novel modes‐of‐action. RESULTS Herein, we devised a series 2,5‐dihydro‐3 H ‐[1,2,4]triazino[5,6‐ b ]indole derivatives decorating disulfide moiety ( W 1 –W 36 ). Bioassay results indicated their antibacterial activity against three [ Xoo Xanthomonas oryzae pv. ), Xac axonopodis citri ) Psa Pseudomonas syringae actinidiae )]. Compound demonstrated eminent anti‐ vitro , median effecgtive concentration (EC 50 value 0.77 μg mL −1 which was considerably higher than that reference agent thiodiazole copper (TC, EC = 104 At 200 compound better vivo control efficiency (46.09% curative activity; 51.26% protective activity) toward rice bacterial blight diseases, >20% increase relative to TC. Mechanistic studies revealed enabled suppression activities oxidoreductases including superoxide dismutase catalase, disrupted redox balance, ultimately induced cell apoptosis. CONCLUSION Overall, these new molecules were characterized high ability, reactive oxygen species targeting performance, low toxicity. They unprecedented potential controlling infection. © 2025 Society Chemical Industry.

Язык: Английский

Isoxazoline: An Emerging Scaffold in Pesticide Discovery DOI
Lingjie Kong, Xinyu Cao,

Na-Bo Sun

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Isoxazolines are five-membered heterocycle compounds with a wide range of pharmacological and pesticidal activities. Numerous marketed pesticides contain an isoxazoline motif as key skeleton. Isoxazoline have relatively simple syntheses biological activities against various weeds, bacteria, other pests. In recent years, they received increasing attention widely used in organic chemistry research, such intermediate catalyst ligands synthesis. They also excellent optoelectronic properties the field materials. Hence, exploration derivatives remains important research area pesticide discovery. This review provides up-to-date overview utilized discovery, highlighting their structure properties. It summarizes relevant publications from last 10 offering insights into advancements this research.

Язык: Английский

Процитировано

0
Novel 2,5‐dihydro‐3H‐[1,2,4]triazino[5,6‐b]indole derivatives decorated with disulfide moiety are effective for treating bacterial infections by inducing reactive oxygen species DOI
Guoqing Wang,

Hong‐Wu Liu,

Ya Zhou

и другие.

Pest Management Science, Год журнала: 2025, Номер unknown

Опубликована: Май 14, 2025

Abstract BACKGROUND Infectious diseases caused by pathogenic bacteria are the main causes of death in humans, and responsible for reduced yield quality quantity plants globally. This underscores need developing bactericide alternatives with novel modes‐of‐action. RESULTS Herein, we devised a series 2,5‐dihydro‐3 H ‐[1,2,4]triazino[5,6‐ b ]indole derivatives decorating disulfide moiety ( W 1 –W 36 ). Bioassay results indicated their antibacterial activity against three [ Xoo Xanthomonas oryzae pv. ), Xac axonopodis citri ) Psa Pseudomonas syringae actinidiae )]. Compound demonstrated eminent anti‐ vitro , median effecgtive concentration (EC 50 value 0.77 μg mL −1 which was considerably higher than that reference agent thiodiazole copper (TC, EC = 104 At 200 compound better vivo control efficiency (46.09% curative activity; 51.26% protective activity) toward rice bacterial blight diseases, >20% increase relative to TC. Mechanistic studies revealed enabled suppression activities oxidoreductases including superoxide dismutase catalase, disrupted redox balance, ultimately induced cell apoptosis. CONCLUSION Overall, these new molecules were characterized high ability, reactive oxygen species targeting performance, low toxicity. They unprecedented potential controlling infection. © 2025 Society Chemical Industry.

Язык: Английский

Процитировано

0