Safety Evaluation of Fermented and Nonfermented Moringa oleifera Seeds in Healthy Albino Rats: Biochemical, Haematological, and Histological Studies
International Journal of Food Science,
Год журнала:
2025,
Номер
2025(1)
Опубликована: Янв. 1, 2025
Fermentation
preserves
and
enhances
food
properties,
but
consuming
locally
fermented
foods
can
cause
health
issues
like
flatulence,
gastrointestinal
disorders,
kidney
stones,
sometimes
death.
This
study
evaluated
the
biochemical,
haematological,
histological
effects
of
supplementing
diets
with
Moringa
oleifera
seed
(FMS)
nonfermented
(NFMS)
in
healthy
albino
rats.
Male
rats
were
fed
containing
10%,
20%,
30%
FMS
NFMS
for
14
days.
No
significant
changes
observed
body
weight
or
organ/body
ratios.
However,
platelet
count
increased
significantly
(p
<
0.05)
at
higher
supplementation
levels,
suggesting
enhanced
haemostatic
activity.
While
haematological
parameters
remained
stable,
20%
urea
creatinine
indicating
potential
renal
stress.
Histological
analysis
showed
mild
alterations
more
pronounced
NFMS-fed
mitigated
antinutrient
effects,
enhancing
safety.
are
safe
up
to
inclusion,
applications
human
nutrition
functional
development.
Язык: Английский
Review of the Protective Effects of Selenium against T-2 Toxin-Induced Toxicity
Chemical Research in Toxicology,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 21, 2025
The
objective
of
the
present
study
was
to
review
potential
protective
effects
Se
against
T-2
toxin-induced
adverse
in
cartilage
and
other
tissues
as
well
discuss
molecular
mechanisms
by
which
counteracts
toxicity.
Laboratory
studies
demonstrate
that
attenuates
chondrocyte
death
inhibition
mitochondrial
pathway
apoptosis.
Protective
oxidative
stress
chondrocytes
are
mediated
improvement
antioxidant
selenoprotein
expression,
is
altered
upon
mycotoxin
exposure.
In
addition
stress,
treatment
associated
with
mycotoxin-induced
ferroptosis.
Along
prevention
damage,
improves
extracellular
matrix
(ECM)
metabolism
up-regulation
type
II
collagen
proteoglycans
expression
ECM
degradation
metalloproteinases.
It
also
noteworthy
part
interactive
between
toxin
exposure
epigenetic
mechanisms,
especially
modulation
noncoding
RNA
expression.
Recent
evidence
shows
mitigates
toxic
liver,
kidney,
immune
system,
organs.
Notably,
a
number
demonstrated
deficiency
aggravates
exposure,
supporting
notion
Se.
However,
existing
data
were
obtained
laboratory
vivo
vitro
models,
therapeutic
supplementation
toxin-exposed
human
subjects
have
yet
be
fully
characterized.
Язык: Английский