Discovery of Coumarin-7-N/O-Acethydrazide Derivatives as Novel Antifungal and Herbicidal Agents DOI
Yufei Li, Shanshan Yang, Yifan Zheng

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Июнь 3, 2025

Natural products (NPs) have attracted increasing attention due to their structural diversity, abundance, and low environmental impact, making them valuable for novel fungicide development. In this study, a series of coumarin-7-N/O acethydrazide derivatives were synthesized by incorporating acetic acid moieties into the coumarin scaffold. The in vitro antifungal activities these compounds evaluated against six common plant pathogenic fungi. Compound B13 demonstrated significant effects, with EC50 values 3.24, 1.89, 1.70, 0.36, 4.27, 1.50 μg/mL Botrytis cinerea, Alternaria solani, Fusarium graminearum, Rhizoctonia Colletotrichum orbiculare alternata, respectively. Notably, activity R. solani was comparable commercial boscalid (EC50 = 0.31 μg/mL), while A. alternata significantly higher than that 13.60 2.55 μg/mL, respectively), Furthermore, vivo assays protective efficacy at 200 (86.9%) Validamycin (92.1%). inhibitory effects further confirmed through scanning electron microscopy fluorescence microscopy. influence charge distribution compound on its investigated using Density Functional Theory (DFT). Meanwhile, some exhibited herbicidal four field weeds. These results indicate is promising candidate crop protection, exhibiting high toxicity.

Язык: Английский

Discovery of Coumarin-7-N/O-Acethydrazide Derivatives as Novel Antifungal and Herbicidal Agents DOI
Yufei Li, Shanshan Yang, Yifan Zheng

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Июнь 3, 2025

Natural products (NPs) have attracted increasing attention due to their structural diversity, abundance, and low environmental impact, making them valuable for novel fungicide development. In this study, a series of coumarin-7-N/O acethydrazide derivatives were synthesized by incorporating acetic acid moieties into the coumarin scaffold. The in vitro antifungal activities these compounds evaluated against six common plant pathogenic fungi. Compound B13 demonstrated significant effects, with EC50 values 3.24, 1.89, 1.70, 0.36, 4.27, 1.50 μg/mL Botrytis cinerea, Alternaria solani, Fusarium graminearum, Rhizoctonia Colletotrichum orbiculare alternata, respectively. Notably, activity R. solani was comparable commercial boscalid (EC50 = 0.31 μg/mL), while A. alternata significantly higher than that 13.60 2.55 μg/mL, respectively), Furthermore, vivo assays protective efficacy at 200 (86.9%) Validamycin (92.1%). inhibitory effects further confirmed through scanning electron microscopy fluorescence microscopy. influence charge distribution compound on its investigated using Density Functional Theory (DFT). Meanwhile, some exhibited herbicidal four field weeds. These results indicate is promising candidate crop protection, exhibiting high toxicity.

Язык: Английский

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