Glyphosate combined with TBBPA exposure decreased quality and flavor of common carp (Cyprinus carpio) involved inhibiting muscle growth and collagen synthesis
Pesticide Biochemistry and Physiology,
Год журнала:
2025,
Номер
209, С. 106344 - 106344
Опубликована: Фев. 21, 2025
Язык: Английский
Liver injury in sepsis: manifestations, mechanisms and emerging therapeutic strategies
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Март 28, 2025
Sepsis
is
defined
as
a
condition
related
to
infection
that
manifests
with
multiorgan
dysfunction,
representing
life-threatening
state.
Consequently,
severe
complications
frequently
occur,
liver
injury
being
one
of
the
most
prevalent
serious
sepsis.
Liver
dysfunction
during
sepsis
serves
an
independent
predictor
mortality.
This
review
provides
comprehensive
overview
current
research
on
sepsis-induced
(SILI),
encompassing
clinical
manifestations,
diagnostic
criteria,
pathogenesis
and
therapeutic
strategies
associated
this
condition.
SILI
may
manifest
hypoxic
hepatitis
due
ischemia
shock,
cholestasis
resulting
from
abnormal
bile
metabolism,
or
duct
sclerosis.
The
pathophysiology
involves
intricate
interactions
among
inflammatory
response,
oxidative
stress,
cell
death.
All
these
factors
complicate
treatment
represent
potential
targets
for
intervention.
Furthermore,
addresses
limitations
inherent
in
conventional
therapies
currently
employed
managing
emphasizes
novel
targeted
aimed
at
addressing
fundamental
mechanisms
underlying
Язык: Английский
Importance of Selenoprotein O in Regulating Hmgb1: A New Direction for Modulating ROS-Dependent NETs Formation to Aggravate the Progression of Acute Liver Inflammation
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 6, 2025
Selenoproteins
(Sels)
are
a
class
of
essential
biomolecules
that
play
critical
roles
in
cellular
homeostasis.
SelO
was
identified
as
the
preferential
source
selenium
liver,
implying
its
potential
key
regulatory
factor
hepatic
pathophysiology.
Bioinformatics
analysis
data
from
GEO
sets
revealed
marked
downregulation
liver
injury.
However,
function
and
mechanisms
remain
unclear.
To
address
this,
we
investigated
effect
ablation
on
acute
inflammation,
focusing
association
with
inflammation
neutrophil
extracellular
traps
(NETs)
formation.
Wild-type
(WT)
SelO-knockout
mice
were
used
to
establish
lipopolysaccharide
(LPS)
exposure
model
coculture
(AML12
cells
neutrophils)
vitro.
Our
findings
LPS
stimulation
significantly
reduced
expression
WT
mouse
liver.
deletion
promoted
Hmgb1
marker
cytokines
for
chemokines,
NETs
generation,
pyroptosis
induced
an
imbalance
redox
Immunofluorescence,
SYTOX
staining,
scanning
electron
microscopy
confirmed
silencing
reactive
oxygen
species
(ROS)-dependent
Moreover,
demonstrated
excessive
formation
exacerbated
SelO-ablation-induced
inflammation.
Importantly,
significant
involvement
Hmgb1/ROS
axis
development
absence
SelO.
results
recruitment
enhanced
ROS-dependent
by
increasing
levels,
thereby
aggravating
LPS-induced
This
study
not
only
uncovered
crucial
biological
functions
SelO,
but
also
shed
light
implications
inflammatory
process.
Язык: Английский
Apigenin-Mediated ESCRT-III Activation and Mitophagy Alleviate LPS-Induced Necroptosis in Renal Cells
Jiakang Guo,
Jin-Ping Hu,
Meitong Liu
и другие.
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 10, 2025
Apigenin
(API)
is
a
flavonoid
widely
distributed
in
vegetables
and
fruits
that
exhibits
numerous
biological
functions.
Lipopolysaccharide
(LPS),
key
component
of
the
outer
membrane
Gram-negative
bacteria,
can
cause
kidney
injury
when
released
into
bloodstream.
Necroptosis
form
programmed
cell
death
characterized
by
rupture
membranes.
Excessive
occurrence
necroptosis
lead
to
substantial
damage
cells
tissues.
In
study,
we
discovered
API
could
mitigate
LPS-induced
mice
alleviate
Normal
Rat
Kidney-52E
(NRK-52E)
targeting
mitochondrial
reactive
oxygen
species
(mtROS)-RIPK3-MLKL
pathway.
Further
mechanistic
studies
revealed
potentially
activate
endosomal
sorting
complexes
required
for
transport-III
(ESCRT-III),
activated
ESCRT-III
repair
caused
necroptosis.
Simultaneously,
promote
mitophagy,
which
facilitates
timely
removal
damaged
mitochondria
reduces
intracellular
mtROS
levels.
conclusion,
our
results
suggested
alleviates
renal
activating
ESCRT-III-dependent
mitophagy.
Our
study
provides
new
insights
daily
dietary
intake
LPS.
Язык: Английский