Drosophila-associated bacteria differentially shape the nutritional requirements of their host during juvenile growth

PLoS Biology, Год журнала: 2020, Номер 18(3), С. e3000681 - e3000681

Опубликована: Март 20, 2020

The interplay between nutrition and the microbial communities colonizing gastrointestinal tract (i.e., gut microbiota) determines juvenile growth trajectory. Nutritional deficiencies trigger developmental delays, an immature microbiota is a hallmark of pathologies related to childhood undernutrition. However, how host-associated bacteria modulate impact on remains elusive. Here, using gnotobiotic Drosophila melanogaster larvae independently associated with Acetobacter pomorumWJL (ApWJL) Lactobacillus plantarumNC8 (LpNC8), 2 model Drosophila-associated bacteria, we performed large-scale, systematic nutritional screen based larval in 40 different precisely controlled environments. We combined these results genome-based metabolic network reconstruction define biosynthetic capacities germ-free (GF) its bacterial partners. first established that ApWJL LpNC8 differentially fulfill requirements ex-GF parsed such difference down individual amino acids, vitamins, other micronutrients, trace metals. found not only fortify host's diet essential nutrients but, specific instances, functionally compensate for host auxotrophies by either providing intermediate or nutrient derivative uptaking, concentrating, delivering contaminant traces micronutrients. Our work reveals beyond molecular dialogue engaged partners, establish integrated relying provision utilization.

Язык: Английский

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Growth efficiency, intestinal biology, and nutrient utilization and requirements of black soldier fly (Hermetia illucens) larvae compared to monogastric livestock species: a review

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Год журнала: 2022, Номер 13(1)

Опубликована: Май 5, 2022

In recent years, interest in the larvae of black soldier fly (BSF) (Hermetia illucens) as a sustainable protein resource for livestock feed has increased considerably. However, knowledge on nutritional and physiological aspects this insect, especially compared to other conventional farmed animals is scarce. This review presents critical comparison data growth potential efficiency BSF (BSFL) monogastric species. Advantages BSFL over species includes their high rate ability convert low-grade organic waste into high-quality fat-rich biomass suitable use animal feed. Calculations using literature suggest that are more efficient than broilers, pigs fish terms conversion substrate body mass, but less broilers utilization gross energy gain mass. varies greatly depending nutrient quality dietary substrates. might be associated with function gastrointestinal tract, including activity digestive enzymes, particle characteristics, intestinal microbial community. The conceived advantage having an environmental footprint better only true if produced its would directly used human consumption. Therefore, role new close cycles agro-ecological systems needs reconsidered, we conclude complementary efficiently utilizing cannot utilized by livestock. addition, provide comparative insight morpho-functional gut, characterization gut microbiota fiber digestion. Finally, current requirements macro- micro-nutrients reviewed found rather limited. research methods determine not applicable BSFL. Thus, there great need

Язык: Английский

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Avoiding cantharidin through ionotropic receptors

Journal of Hazardous Materials, Год журнала: 2024, Номер 466, С. 133497 - 133497

Опубликована: Янв. 11, 2024

Язык: Английский

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Red ginseng has stronger anti-aging effects compared to ginseng possibly due to its regulation of oxidative stress and the gut microbiota

Phytomedicine, Год журнала: 2021, Номер 93, С. 153772 - 153772

Опубликована: Сен. 23, 2021

Язык: Английский

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The Role and Mechanism of Polysaccharides in Anti-Aging

Nutrients, Год журнала: 2022, Номер 14(24), С. 5330 - 5330

Опубликована: Дек. 15, 2022

The elderly proportion of the population is gradually increasing, which poses a great burden to society, economy, and medical field. Aging physiological process involving multiple organs numerous reactions, therefore it not easily explained or defined. At present, growing number studies are focused on mechanisms aging potential strategies delay aging. Some clinical drugs have been demonstrated anti-aging effects; however, many still deficits with respect safety long-term use. Polysaccharides natural efficient biological macromolecules that act as antioxidants, anti-inflammatories, immune regulators. Not surprisingly, these molecules recently gained attention for their use in therapies. In fact, polysaccharides found excellent effects different animal models including Caenorhabditis elegans, Drosophila melanogaster, mice. qualities linked several mechanisms, such improved antioxidant capacity, regulation age-related gene expression, function. Here, we summarize current findings from research related based various models, focus main oxidative damage, genes pathways, modulation, telomere attrition. This review aims provide reference further polysaccharides.

Язык: Английский

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Study on the material basis and mechanism of Hemerocallis citrina Baroni on sleep-improvement using Drosophila activity monitoring, metabolomic, targeted screening and transcriptomic

Food Research International, Год журнала: 2023, Номер 172, С. 112562 - 112562

Опубликована: Фев. 6, 2023

Язык: Английский

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Edible plant oils with high n-3/n-6 polyunsaturated fatty acids ratio prolong the lifespan of Drosophila by modulating lipid metabolism

Food Chemistry, Год журнала: 2025, Номер 474, С. 143121 - 143121

Опубликована: Янв. 31, 2025

Язык: Английский

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Climate change effects on the human gut microbiome: complex mechanisms and global inequities

The Lancet Planetary Health, Год журнала: 2025, Номер 9(2), С. e134 - e144

Опубликована: Фев. 1, 2025

Ongoing global climate change is affecting all aspects of life on Earth, including human health. The gut microbiota an important determinant health in humans and other organisms, but how affects remains largely unexplored. In this Review, I discuss the changing might affect by altering quantity quality food, as well environmental microbiomes, such enteric pathogen pressure host physiology. Climate change-induced variability food supply, shifts elemental macromolecular composition plant animal proliferation pathogens, direct effects high temperatures physiology alter undesirable ways, increasing burden change. importance different pathways depend many geographical, economic, ecological factors. Microbiomes populations low-income countries be disproportionally affected through greater poor mitigation diet, burden,

Язык: Английский

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Drosophila melanogaster in nutrition research—the importance of standardizing experimental diets

Genes & Nutrition, Год журнала: 2019, Номер 14(1)

Опубликована: Фев. 1, 2019

The fruit fly Drosophila melanogaster has been increasingly recognized as an important model organism in nutrition research. In order to conduct nutritional studies flies, special attention should be given the composition of experimental diets. Besides complex diets, which are often based on maize, yeast, sucrose, and agar, can also fed chemically defined These so-called holidic diets standardized terms their macro- micronutrient although quantitative nutrient requirements flies have yet not fully established warrant further investigations. For instance, only few address fatty acid, vitamin, mineral, trace element flies. D. may interest field medicine. Diet-induced diabetes obesity models established, this context, often, high-fat high-sugar fed. However, these is sufficiently varies between studies. A consensus within scientific community needs reached standardize exact for Since valuable system numerous human diseases, a prerequisite diet-disease interaction We suggest that comprehensive approach, combines deep phenotyping with disease-related under dietary conditions, might lead foundation clinic.

Язык: Английский

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Drosophila melanogaster as an alternative model organism in nutrigenomics

Genes & Nutrition, Год журнала: 2019, Номер 14(1)

Опубликована: Май 6, 2019

Nutrigenomics explains the interaction between genome, proteome, epigenome, metabolome, and microbiome with nutritional environment of an organism. It is therefore situated at interface organism's health, its diet, genome. The diet and/or specific dietary compounds are able to affect not only gene expression patterns, but also epigenetic mechanisms as well production metabolites bacterial composition microbiota. Drosophila melanogaster provides a well-suited model organism unravel these interactions in context nutrigenomics it combines several advantages including affordable maintenance, short generation time, high fecundity, relatively life expectancy, well-characterized availability mutant fly lines. Furthermore, hosts mammalian-like intestinal system clear microbiota fat body resembling adipose tissue liver-equivalent oenocytes, supporting excellent research. Experimental approaches that essentially needed nutrigenomic research, sequencing technologies, have already been established fruit fly. However, studies investigating currently very limited. present review overview fly's morphology antimicrobial peptides modulators immune system. Additionally, summarizes helping elucidate host-genome melanogaster.

Язык: Английский

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