Image-guided cancer surgery: a narrative review on imaging modalities and emerging nanotechnology strategies
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Май 18, 2023
Abstract
Surgical
resection
is
the
cornerstone
of
solid
tumour
treatment.
Current
techniques
for
evaluating
margin
statuses,
such
as
frozen
section,
imprint
cytology,
and
intraoperative
ultrasound,
are
helpful.
However,
an
assessment
margins
that
accurate
safe
clinically
necessary.
Positive
surgical
(PSM)
have
a
well-documented
negative
effect
on
treatment
outcomes
survival.
As
result,
imaging
methods
now
practical
method
reducing
PSM
rates
improving
efficiency
debulking
surgery.
Because
their
unique
characteristics,
nanoparticles
can
function
contrast
agents
in
image-guided
While
most
applications
utilizing
nanotechnology
preclinical
stage,
some
beginning
to
reach
clinical
phase.
Here,
we
list
various
used
surgery,
optical
imaging,
computed
tomography,
magnetic
resonance
nuclear
medicine
current
developments
potential
detect
malignancies.
In
coming
years,
will
see
evolution
tailored
specific
types
introduction
equipment
improve
accuracy.
Although
promise
producing
exogenous
molecular
has
been
clearly
demonstrated,
much
work
remains
be
done
put
it
into
practice.
Graphical
Язык: Английский
Synthesis, preclinical, and initial clinical evaluation of integrin αVβ3 and gastrin-releasing peptide receptor (GRPR) dual-targeting radiotracer [68Ga]Ga-RGD-RM26-03
European Journal of Nuclear Medicine and Molecular Imaging,
Год журнала:
2024,
Номер
51(7), С. 2023 - 2035
Опубликована: Фев. 20, 2024
Язык: Английский
Preclinical evaluation of [13xLa]La-FAP-2286 as a novel theranostic agent for tumors expressing fibroblast activation protein
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 3, 2025
In
this
study,
a
novel
theranostic
radiopharmaceutical,
[13xLa]La-FAP-2286,
for
targeting
Fibroblast
Activation
Protein
(FAP)-positive
tumors.
The
pair
of
132La
(half-life:
4.59
h,
42.1%
β⁺)
and
135La
18.91
100%
EC)
was
produced
via
proton
bombardment
natural
barium
in
30
MeV
cyclotron,
achieving
high
radionuclidic
purity
(99.9%)
radiochemical
(RCP
>
99%).
Stability
tests
revealed
the
RCP
greater
than
91%
over
24
h
human
serum
PBS
buffer.
Cellular
studies
confirmed
binding
affinity
(KD
=
0.51
±
0.12
nM)
effective
internalization
[13xLa]La-FAP-2286
FAP
+
tumor
cells.
Distribution
coefficient
(log
D)
measurements
demonstrated
hydrophilicity
complex
with
value
−
3.21
0.14.
Imaging
biodistribution
tumor-bearing
mice
further
targeting,
significant
uptake
observed
up
to
48
post-injection.
These
results
suggest
can
be
considered
candidate
applications,
offering
both
practical
PET
imaging
targeted
Auger-electron
therapy
cancer
treatment.
Язык: Английский
Physiologically based radiopharmacokinetic (PBRPK) modeling to simulate and analyze radiopharmaceutical therapies: studies of non-linearities, multi-bolus injections, and albumin binding
EJNMMI Radiopharmacy and Chemistry,
Год журнала:
2024,
Номер
9(1)
Опубликована: Янв. 22, 2024
Abstract
Background
We
aimed
to
develop
a
publicly
shared
computational
physiologically
based
pharmacokinetic
(PBPK)
model
reliably
simulate
and
analyze
radiopharmaceutical
therapies
(RPTs),
including
probing
of
hot-cold
ligand
competitions
as
well
alternative
injection
scenarios
drug
designs,
towards
optimal
therapies.
Results
To
handle
the
complexity
PBPK
models
(over
150
differential
equations),
scalable
modeling
notation
called
“reaction
graph”
is
introduced,
enabling
easy
inclusion
various
interactions.
refer
this
radiopharmacokinetic
(PBRPK)
modeling,
fine-tuned
specifically
for
radiopharmaceuticals.
As
three
important
applications,
we
used
our
PBRPK
(1)
study
effect
competition
between
hot
cold
species
on
delivered
doses
tumors
organs
at
risk.
In
addition,
(2)
evaluated
an
paradigm
utilizing
multi-bolus
injections
in
RPTs
instead
prevalent
single
injections.
Finally,
(3)
impact
varying
albumin-binding
affinities
by
ligands,
implications
RPTs.
found
that
labeled
unlabeled
ligands
can
lead
non-linear
relations
injected
activity
dose
particular
organ,
sense
doubling
does
not
necessarily
result
doubled
organ
(a
false
intuition
from
external
beam
radiotherapy).
observed
fractionating
higher
payload
delivery
organs,
though
tumor.
By
contrast,
out
increased
such
delivering
more
tumors,
be
attributed
several
factors
allows
us
probe.
Conclusions
Advanced
enables
simulation
analysis
variety
intervention
design
scenarios,
Язык: Английский
An Overview of Structural Framework and Classification of Theranostic Radiopharmaceuticals
ChemistrySelect,
Год журнала:
2024,
Номер
9(38)
Опубликована: Окт. 1, 2024
Abstract
Radiopharmaceuticals
constitute
the
backbone
of
nuclear
medicine
research
and
have
been
commonly
used
in
diagnostic
imaging
radionuclide
therapy.
In
past,
there
has
a
strong
emphasis
on
meticulous
design
development
radiotheranostics
for
targeted
molecular
therapy
different
types
tumors.
Theranostic
radiopharmaceuticals
offer
synergistic
advantages
simultaneous
all
one
molecule.
Owing
to
their
successful
pre‐clinical
clinical
applications,
many
new
theranostic
explored
recent
years.
This
review
aims
provide
comprehensive
overview
structural
framework
radiopharmaceuticals.
this
review,
we
primarily
focused
chelating
agents,
linkers,
radionuclides
potential
radiotheranostics.
addition,
also
summarizes
classification
categories
such
as
nano‐radiotheranostics
along
with
applications.
The
developments
applications
small
molecule‐based
radiotheranostics,
antibody‐based
peptide‐based
nanoparticle‐based
reviewed
inspiring
efforts
towards
efficient
Язык: Английский
An upgraded solid‐phase assembly of chelators (DOTA and NOTA) enabled bacterial uptake studies of radiolabeled peptide
ChemBioChem,
Год журнала:
2024,
Номер
26(1)
Опубликована: Дек. 11, 2024
Abstract
Among
popular
radio
metal
chelators,
DOTA
and
NOTA
have
been
remarkably
considered
in
radionuclide
therapy
imaging
studies
due
to
several
advantages
pharmacology.
Here,
we
developed
a
practical
general
method
for
assembling
the
solid
phase
peptide
(pseudo‐dilute
conditions)
using
wide
range
of
solvents
with
easily
accessible
economical
feedstocks,
which
mitigated
unprecedented
challenges
associated
previously
reported
methods.
This
upgraded
approach
enabled
an
efficient
installation
these
two
chelators
on
various
bioactive
sequences.
Finally,
assessed
antimicrobial
activity
DOTA‐
NOTA‐attached
Combi
peptides
B.
subtilis
,
was
intact.
The
authenticity
assembled
framework
by
labeling
177
Lu
vitro
bacterial
uptake
E.
coli
S.
aureus
.
Lu‐labeled
DOTA‐Combi
exhibited
promising
developing
infection
agent
while
negligible
hemolysis
even
at
>200
μM.
contribution
will
be
valued
radiopharmaceuticals
operational
simplicity
economic
approaches.
Язык: Английский