Studia Universitatis Moldaviae Seria Științe ale Naturii,
Год журнала:
2023,
Номер
1(171), С. 194 - 205
Опубликована: Сен. 1, 2023
In
this
article,
methods
of
synthesis
and
physicochemical
analysis
5
coordination
compounds
based
on
Cu(II)
ion
3-ethoxysalicylic
aldehyde
4-cyclohexyl-thiosemicarbazone
are
described.
the
first
step,
ligand
was
carried
out
by
means
two
classical
with
subsequent
refinement,
thus
obtaining
H2L
as
a
chelator
copper(II)
ions.
1H,
13C
15N-NMR
spectroscopy,
13C-DEPT-135
NMR
15N
HSQC-NMR
spectroscopy
were
applied
to
investigate
structure
geometry
4-cyclohexyl-thiosemicarbazone.
The
synthesized
substances
analyzed
modern
research
such
as:
FTIR
UV-vis
elemental
analysis,
single
crystal
X-ray
diffraction;
biological
activity
is
under
study.
Inorganic Chemistry,
Год журнала:
2024,
Номер
63(43), С. 20840 - 20858
Опубликована: Окт. 15, 2024
The
coordination
chemistry
and
electrochemistry
of
novel
N-acridine
thiosemicarbazones
(NATs)
were
investigated
along
with
their
redox
activity,
antiproliferative
efficacy,
transmetalation,
dissociation
properties.
ability
NAT
Fe(III)
complexes
to
inhibit
detrimental
oxy-myoglobin
(oxy-Mb)
oxidation
was
also
examined.
NATs
act
as
tridentate
ligands
a
2:1
L/Zn(II)
complex
crystal
structure,
revealing
distorted
octahedral
geometry,
where
both
bind
Zn(II)
in
meridional
conformation.
exhibited
fully
reversible
one-electron
FeIII/II
couples
more
positive
potentials
than
the
related
clinically
trialed
thiosemicarbazone
(e.g.,
[Fe(DpC)2]+)
due
electron-donating
capacity
acridine.
Surprisingly,
NAT-Zn(II)
showed
generally
greater
or
similar
activity
ligands,
Cu(II),
complexes.
This
may
be
explained
by
(1)
formation
highly
lipophilic
that
acts
chaperone
promote
cellular
uptake
(2)
dissociate
undergo
transmetalation
redox-active
Cu(II)
complex.
Of
NAT-Fe(III)
complexes,
[Fe(AOBP)2]+
demonstrated
significant
(p
<
0.0001)
improvement
preventing
oxy-Mb
thiosemicarbazone,
DpC.
article
advances
our
understanding
chemistry,
electrochemistry,
intriguing
biological
Journal of Sulfur Chemistry,
Год журнала:
2024,
Номер
45(3), С. 346 - 363
Опубликована: Март 4, 2024
This
study
describes
the
synthesis
of
novel
chalconethiocarbohydrazones
derived
from
2′-hydroxychalcone
and
thiocarbohydrazide
as
potential
drugs.
The
monothiocarbohydrazone
(M1)
bisthiocarbohydrazone
(M2)
compounds
were
obtained
by
condensing
with
[1-(2-hydroxyphenyl)−3-phenyl-2-propen-1-one]
at
1/1
1/2
mol
ratios.
synthesized
characterized
elemental
analysis,
1H
NMR,
FT-IR
UV-Vis
spectroscopic
techniques.
crystal
structures
M1
M2
solved
using
single
X-ray
diffraction
method.
total
antioxidant
capacities
thiocarbohydrazones
determined
Cupric
Reducing
Antioxidant
Capacity
(CUPRAC)
It
was
investigated
also
radical
scavenging
activities
these
2,2-Diphenyl-1-picrylhydrazyl
(DPPH)
When
compared
to
standard
compound
Trolox,
both
showed
good
activity.
For
new
compounds,
Conceptual
Density
Functional
Theory
(CDFT)
computations
performed
compute
important
quantum
chemical
reactivity
descriptors.
reactivities
studied
systems
via
well-known
electronic
structure
rules
CDFT.
Experimentally
supported
Molecular
Docking
analyses.
Molbank,
Год журнала:
2024,
Номер
2024(4), С. M1926 - M1926
Опубликована: Ноя. 28, 2024
The
reaction
of
the
phosphonated
hydrazone
(2-hydrazineylidenepropyl)
diphenylphosphine
oxide
1
with
p-fluorophenyl-isothiocyanate
yields
as
a
major
product
thiosemicarbazone
Ph2P(=O)CH2{C=N-NH(C=S)-N(H)C6H4F}CH3
(2-(1-(diphenylphosphoryl)propan-2-ylidene)-N-(4-fluorophenyl)hydrazine-1-carbothioamide)
2
along
bis(N-p-fluorophenylthiourea)
3
minor
product.
latter
compound
was
isolated
main
by
direct
treatment
p-FC6H4N=C=S
hydrazine
in
2:1
ratio.
Both
and
were
characterized
NMR.
Furthermore,
molecular
structure
elucidated
an
X-ray
diffraction
study,
revealing
both
intra-
intermolecular
secondary
interactions.
A
conformational
DFT
at
B3LYP/6-311
G++
(d,
p)
level
theory,
confirms
good
match
between
calculated
experimental
one.
Studia Universitatis Moldaviae Seria Științe ale Naturii,
Год журнала:
2023,
Номер
1(171), С. 194 - 205
Опубликована: Сен. 1, 2023
In
this
article,
methods
of
synthesis
and
physicochemical
analysis
5
coordination
compounds
based
on
Cu(II)
ion
3-ethoxysalicylic
aldehyde
4-cyclohexyl-thiosemicarbazone
are
described.
the
first
step,
ligand
was
carried
out
by
means
two
classical
with
subsequent
refinement,
thus
obtaining
H2L
as
a
chelator
copper(II)
ions.
1H,
13C
15N-NMR
spectroscopy,
13C-DEPT-135
NMR
15N
HSQC-NMR
spectroscopy
were
applied
to
investigate
structure
geometry
4-cyclohexyl-thiosemicarbazone.
The
synthesized
substances
analyzed
modern
research
such
as:
FTIR
UV-vis
elemental
analysis,
single
crystal
X-ray
diffraction;
biological
activity
is
under
study.
