Recent Advances in the Development of Sigma Receptor (Radio)Ligands and Their Application in Tumors
ACS Pharmacology & Translational Science,
Год журнала:
2025,
Номер
8(4), С. 951 - 977
Опубликована: Март 7, 2025
Cancer
ranks
among
the
top
triumvirate
leading
causes
of
human
deaths
worldwide.
The
pathological
mechanisms
are
notably
intricate,
demonstrating
proliferative
and
metastatic
capabilities,
which
complicate
therapeutic
interventions.
sigma-1
receptor
(σ1R)
plays
a
crucial
role
in
tumor
survival
migration,
while
sigma-2
(σ2R)
is
intimately
associated
with
proliferation.
This
review
encapsulated
investigation
concerning
σ1R
σ2R
neoplasms
rigorously
summarized
ligands
radio-ligands
development
their
applications,
such
as
antitumor
cell
proliferation
PET/SPECT
imaging
tumors.
A
comprehensive
classification
discussion
was
undertaken
regarding
chemical
structures
emphasized
possibility
dual/multitargeted
ligands.
Ultimately,
we
discussed
effects
chiral
pharmacological
characteristics
on
affinity
pharmacokinetic
features
vivo,
particularly
radiopharmaceuticals.
functions
beneficial
resource,
fostering
ligand
deployment
stimulating
generation
innovative
ideas
for
developing
Язык: Английский
Diagnostic and Therapeutic Radiopharmaceuticals: A “Hot” Topic
Journal of Medicinal Chemistry,
Год журнала:
2023,
Номер
66(24), С. 16457 - 16463
Опубликована: Дек. 18, 2023
ADVERTISEMENT
RETURN
TO
ISSUEPREVEditorialNEXTDiagnostic
and
Therapeutic
Radiopharmaceuticals:
A
"Hot"
TopicCraig
W.
LindsleyCraig
LindsleyDepartment
of
Pharmacology,
Department
Chemistry,
Vanderbilt
Institute
Chemical
Biology,
School
Medicine,
University,
Nashville,
Tennessee
37232,
United
StatesMore
by
Craig
Lindsleyhttps://orcid.org/0000-0003-0168-1445,
Christa
E.
MüllerChrista
MüllerPharmaCenter
Bonn,
Pharmaceutical
Institute,
&
Medicinal
Rheinische
Friedrich-Wilhelms-Universität
D-53121
GermanyMore
Müllerhttps://orcid.org/0000-0002-0013-6624,
Salvatore
Bongarzone*Salvatore
BongarzoneTechnical
Research
Development,
Novartis,
via
Ribes
5,
Colleretto
Giacosa
10010,
Italy*[email
protected]More
Bongarzonehttps://orcid.org/0000-0002-1309-3045Cite
this:
J.
Med.
Chem.
2023,
66,
24,
16457–16463Publication
Date
(Web):December
18,
2023Publication
History
Received4
December
2023Published
online18
inissue
28
2023https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c02281https://doi.org/10.1021/acs.jmedchem.3c02281editorialACS
PublicationsCopyright
©
2023
American
Society.
This
publication
is
available
under
these
Terms
Use.
Request
reuse
permissions
free
to
access
through
this
site.
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MoreArticle
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SUBJECTS:Biological
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system,Peptides
proteins,Rodent
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Язык: Английский
Novel 18F-Labeled Benzimidazolone-Based Radioligands as Highly Selective Sigma-2 Receptor Probes for Tumor Imaging
Journal of Medicinal Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 23, 2024
Язык: Английский
A Novel Rat Glioblastoma 101/8 Model: A Comparative PET-CT Study with C6 Rat model
Burdenko s Journal of Neurosurgery,
Год журнала:
2024,
Номер
88(6), С. 54 - 54
Опубликована: Янв. 1, 2024
The
development
of
new
drugs
in
nuclear
medicine
for
diagnosis
or
treatment
(chemotherapy)
brain
tumors,
particular
gliomas,
is
inextricably
linked
with
the
use
tumor
models
animals
(usually
rats).
Язык: Английский
Diagnostic and Therapeutic Radiopharmaceuticals: A “Hot” Topic
ACS Pharmacology & Translational Science,
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 18, 2023
ADVERTISEMENT
RETURN
TO
ISSUEEditorialNEXTDiagnostic
and
Therapeutic
Radiopharmaceuticals:
A
"Hot"
TopicCraig
W.
LindsleyCraig
LindsleyDepartment
of
Pharmacology,
Department
Chemistry,
Vanderbilt
Institute
Chemical
Biology,
School
Medicine,
University,
Nashville,
Tennessee
37232,
United
StatesMore
by
Craig
Lindsleyhttps://orcid.org/0000-0003-0168-1445,
Christa
E.
MüllerChrista
MüllerPharmaCenter
Bonn,
Pharmaceutical
Institute,
&
Medicinal
Rheinische
Friedrich-Wilhelms-Universität
D-53121
GermanyMore
Müllerhttps://orcid.org/0000-0002-0013-6624,
Salvatore
Bongarzone*Salvatore
BongarzoneTechnical
Research
Development,
Novartis,
via
Ribes
5,
Colleretto
Giacosa
10010,
Italy*[email
protected]More
Bongarzonehttps://orcid.org/0000-0002-1309-3045Cite
this:
ACS
Pharmacol.
Transl.
Sci.
2024,
7,
1,
1–7Publication
Date
(Web):December
18,
2023Publication
History
Received4
December
2023Published
online18
inissue
12
January
2024https://pubs.acs.org/doi/10.1021/acsptsci.3c00347https://doi.org/10.1021/acsptsci.3c00347editorialACS
PublicationsCopyright
©
2023
American
Society.
This
publication
is
available
under
these
Terms
Use.
Request
reuse
permissions
free
to
access
through
this
site.
Learn
MoreArticle
Views1198Altmetric-Citations-LEARN
ABOUT
THESE
METRICSArticle
Views
are
the
COUNTER-compliant
sum
full
text
article
downloads
since
November
2008
(both
PDF
HTML)
across
all
institutions
individuals.
These
metrics
regularly
updated
reflect
usage
leading
up
last
few
days.Citations
number
other
articles
citing
article,
calculated
Crossref
daily.
Find
more
information
about
citation
counts.The
Altmetric
Attention
Score
a
quantitative
measure
attention
that
research
has
received
online.
Clicking
on
donut
icon
will
load
page
at
altmetric.com
with
additional
details
score
social
media
presence
for
given
article.
how
calculated.
Share
Add
toView
InAdd
Full
Text
ReferenceAdd
Description
ExportRISCitationCitation
abstractCitation
referencesMore
Options
onFacebookTwitterWechatLinked
InRedditEmail
(1
MB)
Get
e-AlertscloseSupporting
Info
(1)»Supporting
Information
Supporting
SUBJECTS:Biological
imaging,Central
nervous
system,Peptides
proteins,Receptors,Rodent
models
e-Alerts
Язык: Английский