Iridium-catalyzed reductive β-alkylation of (iso)quinoline derivatives by an in situ enone-trapping strategy
Yan-Ping Sun,
Jianjie Chen,
Min Zhang
и другие.
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(22), С. 4516 - 4520
Опубликована: Янв. 1, 2024
Here,
we
report
an
iridium-catalyzed
reductive
β-alkylation
of
(iso)quinolinium
salts
with
β-chloro
ketones,
which
offers
important
complement
to
the
synthesis
functionalized
(iso)tetrahydroquinolines.
Язык: Английский
Theoretical Study of Aromatic and N-Heterocycles: Potential Carriers of Interstellar Aromatic Infrared Bands and Uv Extinction
Опубликована: Янв. 1, 2024
Язык: Английский
The benefits of translating biomedical research at drug discovery institutes
Nature Reviews Drug Discovery,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 26, 2024
Язык: Английский
A Collection of Useful Nuisance Compounds (CONS) for Interrogation of Bioassay Integrity
JACS Au,
Год журнала:
2024,
Номер
4(12), С. 4883 - 4891
Опубликована: Ноя. 25, 2024
High-throughput
screening
(HTS)
is
a
crucial
technique
for
identifying
potential
hits
to
fuel
drug
discovery
pipelines.
However,
this
process
naturally
concentrates
nuisance
compounds
that
are
not
optimizable
yet
signal
positively
in
convincing
manner.
To
be
able
understand
what
types
of
particular
assay
sensitive
to,
would
great
utility
being
prioritize
progressable
over
nonprogressable
hits.
In
study,
we
present
carefully
compiled
set
100
known
interfere
with
readouts
either
phenotypic
or
target-based
screenings.
Readily
accessible
an
assay-ready
plate,
believe
compound
will
interest
the
research
community,
helping
establish
high-quality
HTS
assays
and
identify
promising,
Язык: Английский