Recent development of Schiff-base metal complexes as therapeutic agents for lung cancer

Journal of Molecular Structure, Год журнала: 2024, Номер 1318, С. 139403 - 139403

Опубликована: Июль 22, 2024

Язык: Английский

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The Role of Copper Ions in Mediating the Anti‐Cancer Effects Using Nanomaterials

Advanced Therapeutics, Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

Abstract Copper plays a pivotal role in human physiology, particularly oncology, acting both as facilitator of progression and also potential avenue for advanced therapeutic approaches. Maintaining copper homeostasis is crucial. The dysregulation implicated tumor growth through its involvement critical processes angiogenesis, proliferation, metastasis. elevation level the microenvironment (TME) activates oncogenic pathways to drive neovascularization sustained malignancies. However, same reliance on offers unique weakness that can be leveraged innovative interventions. recent advances nanomedicine enable synthesis nanostructures help modulate with precision offering multifaceted approaches copper‐based cancer therapy controlled release mechanism, optimized structures induce cuproptosis, selective eradication cells minimum systemic toxicity. This review explores dual biology, emphasizing contribution tumors emerging application targeted therapy. highlights harnessing therapies their transformative from bench bed side novel, highly effective, clinical safety.

Язык: Английский

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Developing a Palladium(II) Agent to Overcome Multidrug Resistance and Metastasis of Liver Tumor by Targeted Multiacting on Tumor Cell, Inactivating Cancer-Associated Fibroblast and Activating Immune Response

Journal of Medicinal Chemistry, Год журнала: 2024, Номер 67(18), С. 16296 - 16310

Опубликована: Сен. 5, 2024

To targeted overcome the multidrug resistance (MDR) and metastasis of liver tumors, we proposed to develop a palladium (Pd) agent based on specific residue human serum albumin (HSA) for multiacting tumor cell other components in microenvironment. this end, series Pd(II) 2-acetylpyridine thiosemicarbazone compounds were optimized obtain compound (5b) with significant cytotoxicity against HepG2/ADM cells. Subsequently, constructed HSA-5b complex delivery system revealed structural mechanism HSA delivering 5b. Importantly, 5b/HSA-5b effectively inhibited growth resistant enhanced targeting ability 5b reduced its side effects

Язык: Английский

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Mechanisms of Copper-Induced Autophagy and Links with Human Diseases

Pharmaceuticals, Год журнала: 2025, Номер 18(1), С. 99 - 99

Опубликована: Янв. 15, 2025

As a structural and catalytic cofactor, copper is involved in many biological pathways required for the biochemistry of all living organisms. However, excess intracellular can induce cell death due to its potential catalyze generation reactive oxygen species, thus homeostasis strictly regulated. And deficiency or accumulation connected with various pathological conditions. Since success platinum-based compounds clinical treatment types neoplasias, metal-based drugs have shown encouraging perspectives drug development. Compared platinum, an essential trace element that may better prospects development than platinum. Recently, therapeutic role copper-induced autophagy chronic diseases such as Parkinson’s, Wilson’s, cardiovascular disease has already been demonstrated. In brief, ions, numerous complexes, copper-based nano-preparations could autophagy, lysosome-dependent process plays important human diseases. this review, we not only focus on current advances elucidating mechanisms compounds/preparations regulation but also outline association between

Язык: Английский

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Design of indomethacin novel small molecule hydrogels for concomitant release and permeability increases

International Journal of Pharmaceutics, Год журнала: 2025, Номер 672, С. 125286 - 125286

Опубликована: Янв. 30, 2025

Язык: Английский

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Lactoferrin Nanoparticle-Vanadium Complex: A Promising High-Efficiency Agent against Glioblastoma by Triggering Autophagy and Ferroptosis

Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 13, 2025

Glioblastoma represents the most aggressive type of brain cancer with minimal clinical advancements in recent decades attributed to absence efficient drug delivery strategies. In this study, we synthesized a series vanadium complexes (V1-V4) and then constructed lactoferrin (LF)-V4 nanoparticle (NP) system. The nanoplatform crossed blood-brain barrier by binding low-density lipoprotein receptor-associated protein-1 selectively targeted glioblastoma, ultimately inhibiting growth situ glioblastoma tumors. LF-V4 NPs induced autophagic cell death U87-MG cells generating reactive oxygen species (ROS) that damaged mitochondria. Further studies revealed triggered lipid peroxidation through accumulation ROS, depletion GSH, downregulation GPX4 SLC7A11, leading ferroptosis cells.

Язык: Английский

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Nanovector approach for co-delivery of Alectinib and hesperidin via inhalational for lung cancer treatment: development, characterization, and preclinical studies

Expert Opinion on Drug Delivery, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

The current study aims to fabricate Nanostructured Lipid Carriers for the co-delivery of Alectinib and Hesperidin (ALB-HSD NLC) non-small cell lung Cancer (NSCLC) via an inhalational route. ALB-HSD NLC was fabricated using Melt emulsification followed by sonication method optimized a central composite design. formulation evaluated various in vitro vivo studies. had satisfactory results particle size, Zeta Potential, PDI, entrapment efficiency. drug release more than 2.5-fold higher compared drugs suspension over 72 hr. A549 human line shows IC50 ALB HSD, were 2.289 µg/mL 73.52 µg/mL, dose-dependent toxicity 0.0209 μg/mL 0.5213 HSD Suspension, respectively, after Pharmacokinetic has demonstrated improved AUC0-t (1.38, 1.57-fold) from suspension. In studies give significant on syngeneic model. prepared could be promising carriers, they succeeded delivering small efficient doses treat NSCLC.

Язык: Английский

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Comparative Study on Covalent and Noncovalent Endogenous Albumin-Binding β-Glucuronidase-Activated SN38 Prodrugs for Antitumor Efficacy

Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 6, 2025

Albumin-binding prodrugs have been explored to overcome the limitations of small-molecule anticancer chemotherapy agents, such as inadequate physiological and pharmaceutical compatibility, well rapid renal clearance. Herein, we investigated two endogenous albumin-binding prodrugs, M-g-SN38 S-g-SN38, forming macromolecular conjugates. Both exhibited robust stability in murine human plasma, crucial for their therapeutic potential. Selective activation by β-glucuronidase ensures minimal toxicity inactive state. Notably, higher cellular uptake, a longer circulation half-life, enhanced tumor accumulation compared suggesting its greater potential improved antitumor efficacy. In vivo, significant activity, leading profound reduction and, many cases, marked depletion complete eradication all treated mice HCT116 xenograft model. Furthermore, also demonstrated pronounced efficacy BxPC-3 Together, these findings provide new insights development prodrugs.

Язык: Английский

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Recent progress in stimuli‐activable metallo‐prodrugs for cancer therapy

Smart Molecules, Год журнала: 2024, Номер unknown

Опубликована: Авг. 29, 2024

Abstract The clinical approval of platinum‐based drugs has prompted the development novel metallo‐complexes during last several decades, while severe problems, especially for poor water solubility, drug resistance and toxicity in patients, greatly hindered trials curative efficacy. To address these issues, concept metallo‐prodrugs been proposed oncology. Some stimuli‐activable provide new insights designing preparing site‐specific prodrugs with maximized therapeutic efficacy negligible unfavorable by‐effects. In this review, recent progress past 20 years overviewed, where endogenous exogenous stimuli have involved. Typical examples smart are discussed regarding to their molecular structure, activation mechanism, promising biomedical applications. end, challenges future perspectives discussed.

Язык: Английский

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Multifunctional human serum albumin-crosslinked and self-assembling nanoparticles for therapy of periodontitis by anti-oxidation, anti-inflammation and osteogenesis

Materials Today Bio, Год журнала: 2024, Номер 28, С. 101163 - 101163

Опубликована: Июль 22, 2024

Periodontitis is a chronic inflammatory disease that can result in the irreversible loss of tooth-supporting tissues and elevate likelihood intensity systemic diseases. The presence reactive oxygen species (ROS) associated related oxidative stress intricately linked to progression severity periodontal inflammation. Targeted removal local ROS may serve attenuate inflammation, improve unfavorable microenvironment potentially reverse ensuing pathological cascades. These scavenging nanoparticles, which possess additional characteristics such as anti-inflammation osteogenic differentiation, are highly sought after for treatment periodontitis. In this study, negative charged human serum albumin-crosslinked manganese-doped self-assembling Prussian blue nanoparticles (HSA-MDSPB NPs) were fabricated. demonstrate ability scavenge multiple including superoxide anion, free hydroxyl radicals, singlet hydrogen peroxide. Additionally, HSA-MDSPB NPs exhibit capacity alleviate inflammation gingiva alveolar bone both vitro vivo. Furthermore, have been shown play role promoting polarization macrophages from M1 M2 phenotype, resulting reduced production pro-inflammatory cytokines. More attractively, demonstrated enhance cellular differentiation. properties contribute decreased extracellular matrix degradation tissue. conclusion, multifunctional nature provides promising therapeutic approach

Язык: Английский

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