Targeting lysosomes by design: novel N-acridine thiosemicarbazones that enable direct detection of intracellular drug localization and overcome P-glycoprotein (Pgp)-mediated resistance
Chemical Science,
Год журнала:
2024,
Номер
15(37), С. 15109 - 15124
Опубликована: Янв. 1, 2024
Innovative
Язык: Английский
Novel ꞵ-carboline/cyanoisoflavone photosensitizers for ferroptosis-induced efficient chemo-photodynamic synergistic cancer therapy
Journal of Photochemistry and Photobiology B Biology,
Год журнала:
2025,
Номер
265, С. 113135 - 113135
Опубликована: Фев. 23, 2025
Язык: Английский
Bio-molecular Fe(III) and Zn(II) complexes stimulate the interplay between PI3K/AKT1/EGFR inhibition and induce autophagy and apoptosis in epidermal skin cell cancer
Journal of Inorganic Biochemistry,
Год журнала:
2024,
Номер
262, С. 112720 - 112720
Опубликована: Сен. 4, 2024
Язык: Английский
Innovative N-Acridine Thiosemicarbazones and Their Zn(II) Complexes Transmetallate with Cu(II): Redox Activity and Suppression of Detrimental Oxy-Myoglobin Oxidation
Inorganic Chemistry,
Год журнала:
2024,
Номер
63(43), С. 20840 - 20858
Опубликована: Окт. 15, 2024
The
coordination
chemistry
and
electrochemistry
of
novel
N-acridine
thiosemicarbazones
(NATs)
were
investigated
along
with
their
redox
activity,
antiproliferative
efficacy,
transmetalation,
dissociation
properties.
ability
NAT
Fe(III)
complexes
to
inhibit
detrimental
oxy-myoglobin
(oxy-Mb)
oxidation
was
also
examined.
NATs
act
as
tridentate
ligands
a
2:1
L/Zn(II)
complex
crystal
structure,
revealing
distorted
octahedral
geometry,
where
both
bind
Zn(II)
in
meridional
conformation.
exhibited
fully
reversible
one-electron
FeIII/II
couples
more
positive
potentials
than
the
related
clinically
trialed
thiosemicarbazone
(e.g.,
[Fe(DpC)2]+)
due
electron-donating
capacity
acridine.
Surprisingly,
NAT-Zn(II)
showed
generally
greater
or
similar
activity
ligands,
Cu(II),
complexes.
This
may
be
explained
by
(1)
formation
highly
lipophilic
that
acts
chaperone
promote
cellular
uptake
(2)
dissociate
undergo
transmetalation
redox-active
Cu(II)
complex.
Of
NAT-Fe(III)
complexes,
[Fe(AOBP)2]+
demonstrated
significant
(p
<
0.0001)
improvement
preventing
oxy-Mb
thiosemicarbazone,
DpC.
article
advances
our
understanding
chemistry,
electrochemistry,
intriguing
biological
Язык: Английский
Novel Copper(II) Coordination Compounds Containing Pyridine Derivatives of N4-Methoxyphenyl-Thiosemicarbazones with Selective Anticancer Activity
Molecules,
Год журнала:
2024,
Номер
29(24), С. 6002 - 6002
Опубликована: Дек. 19, 2024
Ten
coordination
compounds,
[Cu(L1)Cl]
(C1),
[Cu(L1)NO3]
(C2),
[Cu(L2)Cl]
(C3),
[Cu(L2)NO3]
(C4),
[Cu(L3)Cl]
(C5),
[Cu(L3)NO3]
(C6),
[Cu(L4)NO3]
(C7),
[Cu(L4)Cl]
(C8),
[Cu(L5)Cl]
(C9),
and
[Cu(L5)NO3]
(C10),
containing
pyridine
derivatives
of
N4-methoxyphenyl-thiosemicarbazones
were
synthesized
characterized.
The
molecular
structure
four
compounds
was
investigated
using
single
crystal
X-ray
diffraction.
Spectral
analysis
techniques
such
as
FT-IR,
1H
NMR,
13C
elemental
analysis,
molar
conductivity
used
for
all
the
compounds.
tested
evaluated
their
anticancer
activity
selectivity
against
a
variety
cancer
cell
lines,
including
HL-60,
LNCaP,
MCF-7,
HepG-2,
K-562,
HeLa,
BxPC-3,
RD,
MDCK
normal
line.
Most
demonstrated
selective
superior
to
doxorubicin.
Notably,
ligands
showed
high
antiproliferative
HL-60
cells,
with
IC50
values
between
0.01
0.06
µM
index
5000.
Coordination
copper(II)
HL1
HL3
notably
enhanced
activity,
lowering
0.03
µM.
Additionally,
antioxidant
these
assessed,
revealing
that
most
exhibited
greater
compared
Trolox,
some
showing
up
12.3
times
higher.
Toxicity
studies
on
Daphnia
magna
indicated
low
toxicity
ligands,
generally
less
than
doxorubicin,
LC50
ranging
from
13
90
µM,
suggesting
moderate
toxicity.
Conversely,
complexes
more
toxic,
0.5
Язык: Английский
Organoselenium compounds beyond antioxidants
Future Medicinal Chemistry,
Год журнала:
2024,
Номер
unknown, С. 1 - 23
Опубликована: Дек. 22, 2024
Organoselenium
chemistry
has
become
a
significant
field
due
to
its
role
in
synthesizing
numerous
biologically
active
and
therapeutic
compounds.
In
early
phase,
researchers
focused
on
designing
organoselenium
compounds
with
antioxidant
properties
were
quite
successful.
last
two
decades,
synthetic
chemists
shifted
their
focus
toward
synthesis
of
biological
properties,
moving
beyond
traditional
properties.
The
review
includes
study
organo-selenium
as
anticancer,
antimicrobial,
antiviral,
antidiabetic,
antithyroid,
anti-inflammatory
therapies,
contributing
disease
treatment.
This
covers
the
medicinal
applications
over
past
10
years,
thus
making
it
valuable
resource
for
chemistry.
Язык: Английский