Carboxylesterase-Triggered Theranostic Agent: Advancing Near-Infrared Imaging and Therapeutic Efficacy in Hepatocellular Carcinoma

Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Hepatocellular carcinoma (HCC) poses a global challenge due to the lack of accurate early stage detection methods. Carboxylesterase (CE), key HCC biomarker, presents an ideal target for diagnosis. Herein, we developed novel CE-sensitive fluorescent probe (HFP-CE) that offered powerful near-infrared fluorescence signals and potent synergistic photodynamic/chemodynamic therapeutic effect against HCC. This was synthesized by linking ferrocenecarboxylic acid (a Fenton reagent) HFP-OH photosensitizer) through self-eliminating spacer. activation enabled ratiometric imaging CE, allowing specific differentiation cells from others, exceeding capabilities commercial kits. Moreover, HFP-CE could generate 1O2 •OH upon CE in vitro, triggering both apoptosis ferroptosis cancer cells. Remarkably, real-time tumor visualization effective growth inhibition vivo. study showcased promise as versatile tool advancing precision medicine

Язык: Английский

Near-Infrared emitting aza-BODIPY fluorophores, impact of N,N-dialkylamino groups on the photophysical properties: synthesis, characterization, and computational studies

Dyes and Pigments, Год журнала: 2025, Номер unknown, С. 112773 - 112773

Опубликована: Март 1, 2025

Язык: Английский

NIR-II emitting B,O-chelated twisted dye aza-BODIPY for phototherapy

Dyes and Pigments, Год журнала: 2025, Номер unknown, С. 112855 - 112855

Опубликована: Апрель 1, 2025

Язык: Английский