The Journal of Organic Chemistry,
Год журнала:
2021,
Номер
86(21), С. 14597 - 14607
Опубликована: Окт. 18, 2021
This
report
describes
an
efficient
transition-metal-free
process
toward
the
transfer
hydrogenative
cascade
reaction
between
nitroarenes
and
amines
or
alcohols.
The
developed
redox-economical
approach
was
realized
using
a
combination
of
KOtBu
Et3SiH
as
reagents,
which
allows
synthesis
benzimidazole
derivatives
via
σ-bond
metathesis.
conditions
hold
well
over
wide
range
substrates
embedded
with
diverse
functional
groups
to
deliver
desired
products
in
good
excellent
yields.
mechanistic
proposal
has
been
depicted
on
basis
series
control
experiments,
mass
spectroscopic
evidence
is
supported
by
density
theory
(DFT)
calculations
feasible
energy
profile.
RSC Advances,
Год журнала:
2025,
Номер
15(5), С. 3928 - 3953
Опубликована: Янв. 1, 2025
This
review
studies
magnetically
recoverable
catalysts
designed
for
the
efficient
multicomponent
synthesis
of
organosulfur
compounds.
These
enhance
process
by
combining
efficiency
with
environmental
sustainability.
RSC Advances,
Год журнала:
2023,
Номер
13(46), С. 32734 - 32771
Опубликована: Янв. 1, 2023
This
article
gives
a
comprehensive
review
on
the
synthesis
of
benzimidazoles
including
reaction
mechanisms
and
brief
description
biological
application
benzimidazole
derivatives
by
summarizing
recent
studies.
The Journal of Organic Chemistry,
Год журнала:
2020,
Номер
86(1), С. 1023 - 1036
Опубликована: Дек. 16, 2020
A
straightforward
and
selective
reduction
of
nitroarenes
with
various
alcohols
was
efficiently
developed
using
an
iron
catalyst
via
a
hydrogen
transfer
methodology.
This
protocol
led
specifically
to
imines
in
30–91%
yields,
good
functional
group
tolerance.
Noticeably,
starting
from
o-nitroaniline
derivatives,
the
presence
alcohols,
benzimidazoles
can
be
obtained
64–72%
yields
when
reaction
performed
additional
oxidant,
DDQ,
quinoxalines
were
prepared
1,2-diols
28–96%
yields.
methodology,
unprecedented
at
for
imines,
also
provides
sustainable
alternative
preparation
benzimidazoles.
Advanced Synthesis & Catalysis,
Год журнала:
2023,
Номер
365(7), С. 948 - 964
Опубликована: Фев. 18, 2023
Abstract
The
preparation
of
primary
amines
attracts
huge
attention
in
the
molecular
synthetic
community.
Indeed,
play
a
crucial
role
chemistry
as
they
are
important
substructures
amount
drug
molecules,
agrochemicals,
dyes
and
materials.
Compared
to
stoichiometric
reductions
using
metal
hydride
based
reagents,
catalyzed
reduction
nitroarenes,
nitriles
carboxamides
appears
be
an
attractive
option,
mainly
when
associated
first
row
transition
metals
such
manganese,
iron,
or
cobalt.
In
this
short
review,
we
illustrate
progress
achieved
homogeneous
hydrogenation,
hydrogen
transfer,
borrowing
hydrosilylation
carboxamides.
magnified
image
Advanced Synthesis & Catalysis,
Год журнала:
2021,
Номер
363(15), С. 3859 - 3865
Опубликована: Июнь 24, 2021
Abstract
Starting
from
nitroarenes,
under
hydrosilylation
conditions,
using
a
well‐defined
N
‐heterocyclic
carbene
iron(0)
catalyst,
(IMes)Fe(CO)
4
,
the
corresponding
aniline
derivatives
were
produced
in
61–92%
isolated
yields.
More
impressively,
selective
synthesis
of
cyclic
amines
such
as
pyrrolidines,
piperidines
and
azepanes
conducted
levulinic
acid,
1,5‐
1,6‐keto
acids,
respectively.
The
sequential
procedure
proceeded
both
visible
light
irradiation
thermal
conditions
with
20
examples
yields
up
to
69%.
magnified
image
The Journal of Organic Chemistry,
Год журнала:
2022,
Номер
87(24), С. 16378 - 16389
Опубликована: Ноя. 23, 2022
α-Alkyl
and
α-olefin
nitriles
are
very
important
for
organic
synthesis
medicinal
chemistry.
However,
different
types
of
catalysts
employed
to
achieve
either
α-alkylation
by
borrowing
hydrogen
or
α-olefination
dehydrogenative
coupling
methods.
Designing
developing
high-performance
earth-abundant
that
can
procure
products
from
the
same
starting
materials
remain
a
great
challenge.
Herein,
we
report
an
iron(0)
catalyst
system
achieves
chemoselectivity
between
protocols
simply
changing
base.
A
broad
range
alcohols,
including
benzylic,
linear
aliphatic,
cycloaliphatic,
heterocyclic,
allylic
were
selectively
efficiently
converted
corresponding
products.
Mechanistic
studies
reveal
reaction
mechanism
proceeds
through
pathway.
This
iron
catalytic
protocol
is
environmentally
benign
atom-efficient
with
liberation
H2
H2O
as
green
byproducts.
Organic & Biomolecular Chemistry,
Год журнала:
2022,
Номер
20(39), С. 7713 - 7745
Опубликована: Янв. 1, 2022
Recent
advances
in
C/N
alkylation
using
alcohols
as
alkylating
reagents
via
hydrogen-shuttle
methodologies:
Borrowing
Hydrogen,
Acceptorless
Dehydrogenative
Coupling,
and
Base-mediated
Hydride
Transfer.
Abstract
The
benzene
ring
is
fused
to
the
4
and
5
positions
of
imidazole
in
bicyclic
heterocyclic
aromatic
compound
known
as
benzimidazole.
Benzimidazole
an
important
scaffold
exhibiting
a
wide
range
biological
pharmacological
properties
plays
crucial
role
drug
design.
It
synthesized
by
straightforward
nucleophilic
substitution
reaction
condensation
method
between
o‐phenylenediamine
carbonyl
under
various
conditions.
In
recent
years
benzimidazole
have
gained
more
attention
chemistry
due
their
biomedical
importance.
This
study
focuses
on
synthesis
derivatives
numerous
homogeneous
catalysts
related
from
s‐
block,
p‐
transition
metal,
inner
metal
environmentally
benign
synthetic
approaches,
via
heterogeneous
catalyst
metal‐free
has
several
applications
pharmaceuticals,
agrochemicals
fine
chemicals.
Its
scaffolds
are
omnipresent
bioactive
natural
products
pharmaceutically
compounds.
review
highlights
approaches
studies
reported
year
2020
onwards.
