Polycyclic aromatic compounds,
Год журнала:
2022,
Номер
43(7), С. 6261 - 6276
Опубликована: Авг. 26, 2022
Copper
(II)
complex
immobilized
on
the
surface
of
silica-coated
magnetic
nanoparticles
functionalized
with
di(pyridin-2-yl)amine
(Fe3O4@SiO2-di(pyridin-2-yl)amine-Cu(II))
was
successfully
fabricated
and
characterized
by
various
analyses
including
FT-IR,
SEM,
TEM,
EDX,
TGA,
XRD,
VSM,
AAS
ICP-OES
techniques.
The
catalytic
behavior
Fe3O4@SiO2-di(pyridin-2-yl)amine-Cu(II)
nanocomposite
investigated
in
synthesis
ynones
amides.
Furthermore,
heterogeneous
catalyst
can
be
easily
recovered
external
magnet
reused
for
8
cycles
without
significant
loss
activity.
results
clearly
exhibit
advantages
present
methodology,
namely
low
loading,
high
product
yield,
experimental
simplicity,
broad
substrate
scope
short
reaction
times.
Advanced Synthesis & Catalysis,
Год журнала:
2022,
Номер
364(9), С. 1537 - 1542
Опубликована: Март 11, 2022
Abstract
Iron‐catalyzed
cascade
silyl
radical
addition/6‐
exo
‐trig
cyclization/dearomatization
of
biaryl
ynones
has
been
developed.
This
approach
uses
silane
as
the
precursor
well
silylation
reagent,
1,10‐phenanthroline
ligand,
and
tert
‐butyl
hydroperoxide
(TBHP)
oxidant.
By
employing
this
tandem
process,
a
series
silylated
spiro[5.5]trienones
were
prepared.
magnified
image
Green Chemistry,
Год журнала:
2022,
Номер
25(1), С. 153 - 160
Опубликована: Ноя. 25, 2022
Photo-promoted
cascade
6-exo-trig
spirocyclization
of
biaryl
ynones
with
NH
4
SCN
was
developed
for
the
preparation
various
SCN-containing
spiro[5,5]trienones.
The Journal of Organic Chemistry,
Год журнала:
2022,
Номер
87(6), С. 4273 - 4283
Опубликована: Март 4, 2022
We
report
herein
an
alternative
method
for
the
synthesis
of
seleno-dibenzocycloheptenones
and
seleno-spiro[5.5]trienones
through
radical
cyclization
biaryl
ynones
in
presence
diorganyl
diselenides,
using
Oxone
as
a
green
oxidizing
agent.
The
reactions
were
conducted
acetonitrile
solvent
sealed
tube
at
100
°C.
protocol
is
operationally
simple
scalable,
exhibits
high
regioselectivity,
allows
24
dibenzocycloheptenones/spiro[5.5]trienones
yields
up
to
99%,
17
which
are
unpublished
compounds.
Additionally,
synthetic
transformations
prepared
compounds,
such
oxidation
reduction
reactions,
demonstrated.
Organic & Biomolecular Chemistry,
Год журнала:
2022,
Номер
20(29), С. 5779 - 5783
Опубликована: Янв. 1, 2022
A
visible-light
induced
dearomative
cascade
cyclization
of
biaryl
ynones
with
diselenides
under
photocatalyst
and
external
additive-free
conditions
has
been
explored,
giving
a
series
selenated
spiro[5.5]trienones
in
moderate
to
good
yields.
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(7), С. 4854 - 4862
Опубликована: Март 22, 2023
A
metal/peroxide-free
involved
simple
cascade
6-exo-trig
spirocyclization
of
tert-butyl
nitrite
with
biaryl
ynones
has
been
finished,
which
resulted
in
various
NO2-modified
spiro[5,5]trienones
good
regioselectivity/yields.
variety
scaled-up
experiments,
reduction/epoxidation
operations,
and
mechanistic
studies
were
performed
to
verify
the
merits
process
this
radical
system.
Finally,
structure
spirocycles
was
confirmed
by
single-crystal
X-ray
diffraction.
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
62(6)
Опубликована: Дек. 1, 2022
Dearomatization
reactions
involving
radical
cyclizations
can
facilitate
the
synthesis
of
complex
polycyclic
systems
that
find
applications
in
medicinal
chemistry
and
natural
product
synthesis.
Here
we
employ
redox-neutral
photocatalysis
to
affect
a
spirocyclization
transforms
biaryls
into
spirocyclic
cyclohexadienones
under
mild
reaction
conditions.
In
departure
from
previously
reported
methods,
our
work
demonstrates
polarity
mismatched
addition
nucleophilic
an
electron
rich
arene,
allows
regioselective
2,4-
or
2,5-cyclohexadienones
with
broad
functional
group
tolerance.
By
transforming
spirocycles,
methodology
accesses
underexplored
three-dimensional
chemical
space,
provides
efficient
means
creating
quaternary
spirocenters
apply
first
cytotoxic
plant
metabolite
denobilone
A.
Chemical Communications,
Год журнала:
2024,
Номер
60(36), С. 4834 - 4837
Опубликована: Янв. 1, 2024
A
convenient
method
for
oxidant-promoted
radical
cascade
acylation
or
decarbonylative
alkylation
of
1,7-dienes
with
aldehydes
the
construction
tetracyclic
N-containing
skeletons
has
been
established.
Organic Process Research & Development,
Год журнала:
2022,
Номер
26(8), С. 2281 - 2310
Опубликована: Авг. 2, 2022
This
review
provides
a
summary
of
recently
published
developments
in
the
field
nonprecious
metal
catalysis
(NPMC)
and
highlights
range
synthetic
applications
captured
research
between
July
October
2021.
is
an
installment
series
on
this
area
briefing
Ni,
Cu,
Fe,
Co
catalysis.
There
has
been
evident
increase
publications
NPMC,
which
indicates
widespread
interest
among
laboratories
academia
industry
development
utilization
catalytic
these
metals.
Organic & Biomolecular Chemistry,
Год журнала:
2022,
Номер
20(34), С. 6879 - 6889
Опубликована: Янв. 1, 2022
An
unprecedented
copper-catalyzed
ipso-annulation
reaction
of
N-(p-methoxyaryl)propiolamides
with
1,3-diketones
has
been
developed,
which
enables
the
assembly
diketoalkylated
spiro[4.5]trienones
involving
oxidative
dearomatization
in
presence
ammonium
persulfate
[(NH4)2S2O8]
as
oxidant.
This
protocol
was
extended
to
biaryl
ynones,
efficiently
affording
spiro[5.5]trienones
good
yields.
The
significance
diketoalkyl
functionality
illustrated
by
further
transformation
into
3-pyrazoyl
spiro-trienone,
a
structurally
unique
motif.
