Chemistry - An Asian Journal,
Год журнала:
2022,
Номер
18(3)
Опубликована: Дек. 15, 2022
Abstract
We
report
a
palladium‐catalyzed
intramolecular
direct
heteroarylation
of
oxazole
tethered
β
‐naphthols
to
access
corresponding
tetracyclic
4
H
‐benzo[5,6]chromeno[3,4‐
d
]oxazoles.
Various
functional
groups
are
well
tolerated
and
furnished
the
desired
products
in
good
excellent
yields
under
present
reaction
conditions.
The
scale‐up
synthetic
utility
resulting
molecules
have
been
demonstrated.
Moreover,
UV/vis
absorption
fluorescence
emission
properties
evaluated
for
these
polyheterocyclic
compounds.
Organic Letters,
Год журнала:
2022,
Номер
24(16), С. 3092 - 3096
Опубликована: Апрель 19, 2022
Treatment
of
4-(2-hydroaminoalkylidenyl)-
and
4-(2-hydroxyalkylidenyl)-substituted
isoxazol-5(4H)-ones
with
catalytic
amounts
[RuCl2(p-cymene)]2,
without
any
additive,
afforded
pyrazole-
isoxazole-4-carboxylic
acids,
respectively.
The
presence
an
intramolecular
H-bond
in
these
substrates
was
the
key
to
divert
classical
mechanism
toward
a
ring-opening
non-decarboxylative
path
that
is
expected
generate
vinyl
Ru-nitrenoid
intermediate,
cyclization
which
affords
rearranged
products.
A
gram
scale
protocol
demonstrated
synthetic
applicability
this
transformation.
Catalysts,
Год журнала:
2023,
Номер
13(9), С. 1243 - 1243
Опубликована: Авг. 26, 2023
The
functionalization
of
unactivated
substrates
through
the
combination
copper
catalysts
and
hypervalent
iodine
reagents
represents
a
versatile
tool
in
organic
synthesis
to
access
various
classes
compounds.
derivatives
can
be
used
simply
as
oxidizing
agents
regenerate
catalytic
species
or
they
associate
starting
material.
In
this
review,
special
attention
will
paid
methodologies
which
provide
introduction
nucleophiles
into
reagent
by
use
suitable
benziodoxol(on)es
iodonium
salts.
Many
reactions
concern
C-
N-arylations,
but
may
also
involve
formation
different
carbon–carbon
carbon–nitrogen
bonds,
carbon–oxygen
well
carbon–halogen
carbon–phosphorus
bonds.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(11), С. 2477 - 2482
Опубликована: Апрель 11, 2024
Abstract
Palladium‐catalyzed
conditions
for
diazidation
or
acetoxy/hydroxylation
of
N
‐allyl
sulfonamides
by
using
Pd(OAc)
2
as
the
catalyst
combined
with
Mn(OAc)
3
⋅
2H
O
have
been
developed.
The
1,2‐diazidation
reaction
carbon‐carbon
double
bond
occurs
in
mild
(
i.
e
.
NaN
azide
source
THF
at
room
temperature),
whereas
1,2‐acetoxy/hydroxylation
requires
an
excess
O.
well‐known
ability
this
reagent
to
act
through
single‐electron
transfer
(SET)
makes
plausible
a
radical
mechanism
involving
high
valent
palladium
complexes.
European Journal of Organic Chemistry,
Год журнала:
2022,
Номер
2022(25)
Опубликована: Июнь 6, 2022
Abstract
Easily
accessible
isoxazol‐5(4
H
)‐ones
are
useful
precursors
of
heterocycles.
In
this
context,
we
report
the
ruthenium‐catalyzed
transformation
4‐alkenyl‐substituted
isoxazol‐5‐ones
to
afford
1
‐pyrrole
derivatives.
The
operative
conditions
were
proven
be
effective
also
on
cyclohexane‐fused
isoxazolones
giving
4,5,6,7‐tetrahydroindoles.
reactions,
which
allow
for
access
tri‐and
tetra‐substituted
pyrroles
in
moderate
high
yields,
occur
through
decarboxylative
ring‐opening/ring‐closure
involving
C−H
functionalization
alkenyl
moiety.
Advanced Synthesis & Catalysis,
Год журнала:
2022,
Номер
364(23), С. 4043 - 4048
Опубликована: Окт. 29, 2022
Abstract
A
copper‐catalyzed
tandem
process
integrating
N
‐arylation
and
1,4‐conjugate
addition
is
disclosed
through
the
reaction
of
cyclic
enaminones
ortho
‐halochalcones.
The
appears
to
proceed
chemoselective
arylation
on
nitrogen
enaminone
with
‐halochalcones
Michael
α‐carbon
chalcone
furnish
a
diverse
range
tricyclic
tetrahydroacridinone
derivatives
in
moderate
excellent
yields.
magnified
image
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(19), С. 13995 - 14003
Опубликована: Сен. 25, 2023
A
new
straightforward
approach
to
1-aryl-2-aminopropanes
using
easily
accessible
substrates
has
been
developed.
Simple
allyl
alcohol
is
shown
be
an
ideal
synthetic
equivalent
of
the
C3
propane-1,2-diylium
bis-cation
synthon
in
three-component
cascade
reactions
with
arenes
and
sulfonamide
nucleophiles
regioselectively
afford
1-aryl-2-aminopropanes.
The
reaction
catalyzed
by
Cu(OTf)2
expected
involve
a
Friedel-Crafts-type
allylation
arene,
followed
hydroamination.
European Journal of Organic Chemistry,
Год журнала:
2023,
Номер
26(48)
Опубликована: Ноя. 13, 2023
Abstract
A
very
attractive
approach
toward
1,3‐polyheterocyclic
systems
was
provided
exploiting
the
copper‐catalyzed
reaction
of
aminoalcohols
and
diaminoalkanes,
in
oxidative
conditions
presence
methanol.
The
synthetic
pathway
showed
involvement
methanol
both
as
solvent
a
reagent,
making
procedure
particularly
efficient
sustainable
for
synthesis
five‐,
six‐,
seven‐membered
polyheterocyclic
rings.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(9), С. 8049 - 8049
Опубликована: Апрель 28, 2023
Cancer
poses
a
significant
threat
to
global
health
and
new
treatments
are
required
improve
the
prognosis
for
patients.
Previously,
unconventional
platinum
complexes
designed
incorporate
polypyridyl
ligands
paired
with
diaminocyclohexane
have
demonstrated
anticancer
activity
in
KRAS
mutated
cells,
previously
thought
be
undruggable
cytotoxicity
values
up
100
times
better
than
cisplatin.
In
this
work,
these
were
used
as
inspiration
design
six
novel
cyclometallated
examples,
whose
fluorescence
could
exploited
understand
mechanism
of
action
kinds
drugs.
The
results
revealed
that
(CMCs)
significantly
different
compared
inspired
them;
they
cytotoxic
cisplatin
much
higher
selectivity
indices
breast
cancer
cell
lines
(MCF10A/MCF-7).
Complexes
1b,
2a,
3b
all
had
very
high
indexes
previous
Pt(II)
complexes.
This
prompted
further
investigation
into
their
DNA
binding
properties,
which
good
affinity
ctDNA,
especially
CMCs
1a
3b.
Their
inherent
was
successfully
utilised
calculation
useful
future
work.
Organic Letters,
Год журнала:
2023,
Номер
25(40), С. 7380 - 7384
Опубликована: Сен. 29, 2023
A
phosphine-catalyzed
domino
assembly
of
six
units
2-bromomethyl
acrylates
afforded
polyalkenyl
adducts
containing
two
cyclohexenyl
rings.
This
reaction
occurs
under
mild
conditions
providing
the
final
product
by
formation
seven
carbon-carbon
bonds
and
four
stereocenters.
Experimental
computational
studies
support
an
initial
dimerization
substrate,
which
in
turn
trimerizes
involving
totally
regio-
stereocontrolled
Diels-Alder
cycloadditions.
The
yield
hexamerization
depends
on
size
ester
function.
protocol
has
also
proved
to
be
practicable
a
gram
scale.
