Asian Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 9, 2024
Abstract
A
Sc(OTf)
3
‐catalyzed
tandem
cyclization
reaction
of
o
‐hydroxyphenyl
enaminones
with
1,3,5‐triazinanes
has
been
developed
to
generate
two
distinct
annulated
products
in
moderate
good
yields,
which
is
dominated
by
the
electronic
characteristics
1,3,5‐triazinanes.
The
1,3,5‐triaryl‐1,3,5‐triazinane
reacted
as
C−N
synthon
produce
C3‐aminomethyl
chromone,
while
1,3,5‐trialkyl‐1,3,5‐triazinane
acted
C−N−C−N
synthons
deliver
N
,
‐dialkyl
tetrahydropyrimidine
a
free
hydroxyl
group.
RSC Advances,
Год журнала:
2025,
Номер
15(2), С. 1447 - 1489
Опубликована: Янв. 1, 2025
We
have
reviewed
the
recently
reported
multicomponent
reactions
(MCRs)
yielding
cyclic
frameworks
in
a
single
pot
from
simple
building
blocks
under
mild
conditions.
These
MCRs
may
prove
to
be
useful
for
drug
discovery
projects.
A
novel
domino
strategy
for
the
construction
of
intricate
bridged
bis-thiopyrano[2,3-b]indoles
was
disclosed,
which
involved
one
molecule
3-formylchromones
and
two
molecules
indoline-2-thiones,
enabling
formation
four
new
bonds
in
a
single
operation.
The
transformation
occurred
under
mild
reaction
conditions,
facilitated
by
synergistic
action
base
NaHCO3
catalytic
acid
ZnCl2.
Notably,
when
these
bis-thiopyrano[2,3-b]indole
skeletons
were
treated
with
alkyl
halides
basic
they
underwent
deconstruction
to
yield
alkylthio-substituted
indole-decorated
thiopyrano[2,3-b]indoles.
European Journal of Organic Chemistry,
Год журнала:
2022,
Номер
2022(30)
Опубликована: Май 11, 2022
Abstract
In
the
current
Perspective
article,
we
critically
review
and
discuss
importance
of
solvent
effects
on
multicomponent
reactions,
likely
most
neglected
aspect
in
this
research
field.
Although
solvent‐free
reactions
may
be
desirable
sometimes,
still
require
a
to
properly
promote
them.
This
requirement
makes
knowledge
all
drawbacks
advantages
each
central
issue
when
trying
optimize
reactions.
Yet,
only
few
studies
with
actual
evidence
these
key
have
been
published.
For
quantitative
solvents,
are
even
scarcer.
Perspective,
argue
that
greater
efforts
should
directed
such
fundamental
studies.
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(16), С. 3204 - 3208
Опубликована: Янв. 1, 2024
An
efficient
palladium-catalyzed
[2
+
2
1]
annulation
of
3-iodochromones,
bridged
olefins,
and
iodomethane
is
described,
affording
a
range
chromone-containing
polycyclic
compounds.
Additionally,
the
corresponding
deuterated
products
were
smoothly
obtained
with
iodomethane-
Abstract
An
efficient
solvothermal
method
for
one
pot
batch
simultaneous
synthesis
of
oxazolopyrimidines
and
dihydropyrimidinones
has
been
developed
in
a
small
amount
lactic
acid
without
any
additional
catalysts
additives
the
first
time.
Ten
nine
novel
were
simultaneously
synthesized
by
condensation
1,
3‐dicarbonyl
compounds,
aromatic
aldehydes
β‐hydroxyethylurea
reactors.
All
products
obtained
high
yields
characterized
IR,
1
H
NMR,
13
C
HR‐MS.
Further,
structure
oxazolopyrimidine
undoubtedly
identified
with
means
single
crystal
X‐ray
diffraction.
Synthetic Communications,
Год журнала:
2023,
Номер
53(15), С. 1207 - 1215
Опубликована: Май 21, 2023
An
efficient
process
to
access
chromeno-fused
azafluorenones
(chromeno[2,3-b]indeno[2,1-e]pyridine)
via
the
three-component
reaction
between
2-amino-4H-chromen-4-ones,
aromatic
aldehydes
and
1H-indene-1,3(2H)-dione
is
described.
This
approach
includes
successive
Aldol
condensation,
Michael
addition,
intramolecular
nucleophilic
addition
aromatization.
The
structure
of
a
product
obtained
was
determined
based
on
X-ray
diffraction
studies.
