Angewandte Chemie,
Год журнала:
2024,
Номер
136(28)
Опубликована: Апрель 30, 2024
Abstract
The
development
of
green
and
efficient
deuteration
methods
is
great
significance
for
various
fields
such
as
organic
synthesis,
analytical
chemistry,
medicinal
chemistry.
Herein,
we
have
developed
a
dehalogenative
strategy
using
piezoelectric
materials
catalysts
in
solid‐phase
system
under
ball‐milling
conditions.
This
non‐spontaneous
reaction
induced
by
mechanical
force.
D
2
O
can
serve
both
deuterium
source
an
electron
donor
the
transformation,
eliminating
need
additional
stoichiometric
exogenous
reductants.
A
series
(hetero)aryl
iodides
be
transformed
into
deuterated
products
with
high
incorporation.
method
not
only
effectively
overcomes
existing
synthetic
challenges
but
also
used
labelling
drug
molecules
derivatives.
Bioactivity
experiments
molecule
suggest
that
D‐ipriflavone
enhances
inhibitory
effects
on
osteoclast
differentiation
BMDMs
vitro
.
Mechanochemical
transformations
have
made
chemists
enter
unknown
territories,
forcing
a
different
chemistry
perspective.
While
questioning
or
revisiting
familiar
concepts
belonging
to
solution
chemistry,
mechanochemistry
has
broken
new
ground,
especially
in
the
panorama
of
organic
synthesis.
Not
only
does
it
foster
"thinking
outside
box",
but
also
opened
reaction
paths,
allowing
overcome
weaknesses
traditional
exactly
where
use
well-established
solution-based
methodologies
rules
out
progress.
In
this
Review,
reader
is
introduced
an
intriguing
research
subject
not
yet
fully
explored
and
waiting
for
improved
understanding.
Indeed,
study
mainly
focused
on
that,
although
impossible
solution,
become
possible
under
mechanochemical
processing
conditions,
simultaneously
entailing
innovation
expanding
chemical
space.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(39)
Опубликована: Июль 31, 2023
Abstract
Aryl
fluorides
are
important
structural
motifs
in
many
pharmaceuticals.
Although
the
Balz–Schiemann
reaction
provides
an
entry
to
aryl
from
aryldiazonium
tetrafluoroborates,
it
suffers
drawbacks
such
as
long
time,
high
temperature,
toxic
solvent,
gas
release,
and
low
functional
group
tolerance.
Here,
we
describe
a
general
method
for
synthesis
of
tetrafluoroborates
using
piezoelectric
material
redox
catalyst
under
ball
milling
conditions
presence
Selectfluor.
This
approach
effectively
addresses
aforementioned
limitations.
Furthermore,
can
be
recycled
multiple
times.
Mechanistic
investigations
indicate
that
this
fluorination
may
proceed
via
radical
pathway,
Selectfluor
plays
dual
role
both
source
fluorine
terminal
reductant.
EES Catalysis,
Год журнала:
2024,
Номер
2(4), С. 884 - 910
Опубликована: Янв. 1, 2024
Achieving
value-added
transformation
of
chemicals
through
green
catalytic
technology
can
simultaneously
meet
the
market
and
environmental
protection.
This
article
reviews
recent
advances
in
synthesizing
using
piezo-(photo)catalytic
technologies.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(28)
Опубликована: Апрель 30, 2024
Abstract
The
development
of
green
and
efficient
deuteration
methods
is
great
significance
for
various
fields
such
as
organic
synthesis,
analytical
chemistry,
medicinal
chemistry.
Herein,
we
have
developed
a
dehalogenative
strategy
using
piezoelectric
materials
catalysts
in
solid‐phase
system
under
ball‐milling
conditions.
This
non‐spontaneous
reaction
induced
by
mechanical
force.
D
2
O
can
serve
both
deuterium
source
an
electron
donor
the
transformation,
eliminating
need
additional
stoichiometric
exogenous
reductants.
A
series
(hetero)aryl
iodides
be
transformed
into
deuterated
products
with
high
incorporation.
method
not
only
effectively
overcomes
existing
synthetic
challenges
but
also
used
labelling
drug
molecules
derivatives.
Bioactivity
experiments
molecule
suggest
that
D‐ipriflavone
enhances
inhibitory
effects
on
osteoclast
differentiation
BMDMs
vitro
.
Chinese Journal of Chemistry,
Год журнала:
2022,
Номер
41(1), С. 111 - 128
Опубликована: Сен. 13, 2022
Comprehensive
Summary
Recently,
piezocatalysis
has
attracted
considerable
attention
as
a
new
type
of
renewable
mechanical
energy
conversion
technology,
which
relies
on
the
strain
induced
polarization
piezoelectric
material.
This
technology
been
extensively
applied
in
applications
water
splitting,
remediation,
gas
purification
and
tumor
therapy.
Despite
rapid
development
piezocatalysis,
utilization
materials
for
synthetic
purpose
is
still
under
exploration.
Piezoelectric
means
to
promote
organic
reactions
expand
scope
piezoelectrically
mediated
show
successes
both
polymer
synthesis.
Herein,
we
provide
comprehensive
review
recent
progress
reactions,
catalytic
mechanisms
last
few
years.
The
limitations
future
directions
this
area
are
also
discussed.
We
believe
will
insights
into
underlying
mechanism
electron
transfer
process
guide
design
chemistry.
Advanced Synthesis & Catalysis,
Год журнала:
2022,
Номер
364(15), С. 2462 - 2478
Опубликована: Июнь 16, 2022
Abstract
Cross
dehydrogenative
coupling
(CDC)
reactions
have
become
a
convenient
synthetic
strategy
for
the
synthesis
of
various
(het)aromatic
scaffolds.
In
recent
times
ball
milling
has
emerged
as
powerful
tool
to
perform
in
greener
way.
The
current
review
highlights
applications
cross
under
towards
useful
molecules
more
efficient
and
manner.
magnified
image
Advanced Synthesis & Catalysis,
Год журнала:
2023,
Номер
365(9), С. 1332 - 1384
Опубликована: Март 14, 2023
Abstract
Conjugated
and
non‐conjugated
allenones
appear
as
recurring
motifs
in
organic
synthesis,
natural
products
mechanistic
investigations
showing
unique
properties
applications.
The
ability
of
to
build
cycles
has
provided
a
direct
access
strained
systems,
medium‐sized
rings,
arenes,
heterocycles
complex
polycycles.
In
addition,
have
served
models
catalysis.
critic
compilation
herein
presented
will
provide
an
exhaustive
overview
the
synthetic
possibilities
may
offer,
which
certainly
inspire
our
community
their
search
more
efficient
methodologies,
preparation
biological
pharmaceutical
targets,
improve
knowledge
theoretical
chemistry.
Great
part
this
review
discuss
aspects,
catalysis
innovation
insights
chemical
transformations
implying
allenone
motif.
many
examples
on
total
synthesis
pharmacologically
active
compounds
be
described.
We
hope
that
attractive
chemistry,
catalysis,
medicinal
chemistry
communities.
magnified
image
Chemistry - A European Journal,
Год журнала:
2024,
Номер
30(47)
Опубликована: Июнь 18, 2024
Mechanochemical
reactions,
achieved
through
milling,
grinding,
or
other
mechanical
actions,
have
emerged
as
a
solvent-free
alternative
to
traditional
solution-based
chemistry.
Mechanochemistry
not
only
provides
the
opportunity
eliminate
bulk
solvent
use,
reducing
waste
generation,
but
also
unveils
new
reaction
strategy
which
enables
realization
of
reactions
previously
inaccessible
in
solution.
While
majority
organic
facilitated
by
force
traditionally
follow
two-electron
transfer
pathways
similar
their
counterparts,
field
mechanochemically
induced
single-electron
(SET)
has
witnessed
rapid
development.
This
review
outlines
examples
mechanochemical
SET
process,
focusing
on
reagents
that
initiate
SET,
thereby
positioning
mechanochemistry
burgeoning
within
realm
Faraday Discussions,
Год журнала:
2022,
Номер
241, С. 79 - 90
Опубликована: Июнь 10, 2022
An
electro-mechanochemical
protocol
for
the
synthesis
of
vinylic
sulfoximines
has
been
developed.
Utilising
mechanochemically
strained
BaTiO3
nanoparticles,
catalytic
active
system
is
generated
in
situ
by
reduction
copper(II)
chloride.
Various
combinations
electron-donating
and
-withdrawing
groups
are
tolerated,
approach
leads
to
products
with
difunctionalised
double
bonds
good
excellent
yields.
Attempts
add
a
sulfoximidoyl
chloride
an
alkyne
proved
difficult.
Additions
sulfonyl
iodide
allenes
alkynes
proceeded
smoothly
presence
silica
gel
without
need
activation
piezoelectric
material.
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(18), С. 12891 - 12901
Опубликована: Авг. 24, 2023
An
air-tolerant
mechanoredox/nickel
cocatalyzed
cross
electrophile
coupling
of
benzotriazinones
with
alkyl
(pseudo)halides
is
developed
by
liquid-assisting
grinding
in
the
presence
manganese
powders
and
strontium
titanate
as
a
reductant
cocatalyst,
respectively.
Mechanical
activation
metal
surfaces
via
ball
milling
eliminates
chemical
activator
for
manganese,
while
mechanoredox
cocatalysis
remarkably
improves
aryl/alkyl
piezoelectricity-mediated
radical
generation
from
halides.
Both
display
reactivities
different
those
conventional
thermal
chemistry
solution.
The
scope
reaction
demonstrated
26
examples,
showing
high
chemoselectivity
bromides
vs
chlorides.
