Abstract
The
development
of
innovative
synthetic
strategies
for
constructing
complex
molecular
structures
is
the
heart
organic
chemistry.
This
significance
novel
reactions
or
reaction
sequences
would
further
enhance
if
they
permitted
synthesis
new
classes
structural
motifs,
which
have
not
been
previously
created.
research
on
heterocyclic
compounds
one
most
active
topics
in
chemistry
due
to
widespread
application
N‐heterocycles
life
and
material
science.
a
catalytic
process
that
employs
first‐row
transition
metals
produce
range
heterocycles
from
renewable
raw
materials
considered
highly
sustainable
approach.
be
more
advantageous
done
an
eco‐friendly
atom‐efficient
manner.
Herein
we
introduce,
various
quinoline
based
azafluorenes
via
sequential
dehydrogenative
multicomponent
(MCR)
followed
by
C(sp
3
)−H
hydroxylation
annulation.
Our
newly
developed,
Mn‐complexes
ability
direct
order
achieve
high
amount
desired
functionalized
while
minimizing
possibility
multiple
side
reactions.
We
also
performed
series
control
experiments,
hydride
trapping
kinetics,
intermediate
DFT
studies
comprehend
detailed
route
catalyst‘s
function
MCR
sequence.
Abstract
An
expeditious
strategy
has
been
developed
for
the
synthesis
of
diverse
quinolines,
indenoquinolines
and
acridines
using
KO
t
Bu‐mediated
reaction
conditions.
The
designed
process
utilizes
2‐aminoaryl
carbaldehydes/2‐aminoaryl
ketones
methyl/methylene
group
containing
as
readily
available
feedstock.
chemical
transformation
was
affected
at
room
temperature
within
a
short
duration
time
to
obtain
N
‐heterocycles
yields
up
92
%.
established
also
exhibits
considerable
functional
tolerance
with
an
operational
simplicity.
Molecules,
Год журнала:
2024,
Номер
29(9), С. 1959 - 1959
Опубликована: Апрель 25, 2024
The
Rutaceae
family
is
one
of
the
most
studied
plant
families
due
to
large
number
alkaloids
isolated
from
them
with
outstanding
biological
properties,
among
quinoline-based
Graveoline
1
and
Dubamine
2.
common
methods
for
synthesis
2
their
derivatives
involves
cycloaddition
reactions
or
metal-catalyzed
coupling
processes
but
some
limitations
in
scope
functionalization
quinoline
moiety.
As
a
continuation
our
current
studies
on
chemical
transformation
2-aminochalcones,
we
are
reporting
here
an
efficient
metal-free
approach
total
along
analogues
structural
diversity,
through
two-step
sequence
involving
intramolecular
cyclization,
oxidation/aromatization,
N-methylation
oxidative
C-C
bond
processes,
starting
dihydroquinolin-4-ones
as
precursors
construction
structures
both
classes
alkaloids.
Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
42(22), С. 2818 - 2824
Опубликована: Июль 17, 2024
Comprehensive
Summary
Catalytic
dehydrogenation,
with
its
exceptional
atom
economy
and
chemoselectivity,
offers
a
highly
desirable
yet
challenging
approach
for
converting
multiple
environmentally
friendly
alcohols
into
crucial
molecules.
Furthermore,
the
utilization
of
catalysts
based
on
abundant
elements
found
Earth
alcohol
dehydrogenation
to
produce
acryl
ketone
holds
significant
promise
as
versatile
strategy
in
synthesizing
key
building
blocks
numerous
pharmaceutical
applications.
The
present
study
describes
practical
Co‐catalyzed
cascade
dehydrogenative
Claisen
condensation
secondary
esters,
facilitating
synthesis
wide
range
3‐hydroxy‐prop‐2‐en‐1‐ones.
We
introduce
catalytic
system
novel
scalable
indazole
NNP‐ligands
coordinated
cobalt
efficient
dehydrogenations
alcohols,
propose
plausible
reaction
mechanism
supported
by
control
experiments
labeling
studies.
Notably,
it
allows
streamlined
pharmaceuticals
one‐pot.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(16), С. 11119 - 11135
Опубликована: Июль 26, 2024
The
catalytic
system
generated
in
situ
from
the
cationic
Ru–H
complex
[(C6H6)(PCy3)(CO)RuH]+BF4–
(1)
with
2,3,4,5-tetrachloro-1,2-benzoquinone
(L1)
was
found
to
be
highly
effective
for
promoting
deaminative
coupling
reaction
of
2-aminoaryl
aldehydes
branched
amines
form
2-substituted
quinoline
products.
analogous
ketones
led
regioselective
formation
2,4-disubstituted
A
number
biologically
active
derivatives
including
graveolinine
and
a
triplex
DNA
intercalator
have
been
synthesized
by
using
method.
Dalton Transactions,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Two
cobalt(
ii
)
complexes
C1
and
C2,
supported
by
an
NNN
pincer,
were
synthesized,
characterized
with
various
techniques.
These
utilized
to
study
catalytic
activity
in
the
N
-alkylation
of
amines
via
borrowing
hydrogen
strategy.
Abstract
Recently,
quinoline
has
emerged
as
a
critical
heterocyclic
structure,
attracting
attention
for
its
diverse
industrial
and
synthetic
organic
chemistry
applications.
This
compound
is
essential
developing
novel
lead
compounds
in
drug
discovery
extensively
studied
therapeutic
derivatives
medicinal
chemistry.
An
extensive
body
of
literature
details
the
methodologies
synthesizing
this
key
scaffold
functionalization
to
enhance
biological
efficacy.
Numerous
synthesis
protocols
have
been
documented,
highlighting
significance
ongoing
chemical
research.
These
include
various
strategies,
such
transition
metal‐catalyzed
reactions
environmentally
sustainable
processes,
which
are
crucial
constructing
functionalizing
derivatives.
review
aims
systematically
examine
procedures
findings,
addressing
limitations
these
pathways
their
environmental
impacts.
Additionally,
curated
selection
quinolines
will
be
presented.
Catalysis Science & Technology,
Год журнала:
2023,
Номер
13(10), С. 3069 - 3083
Опубликована: Янв. 1, 2023
Heterogeneous
catalytic
oxidative
dehydrogenative
processes
for
N-heterocycles
are
presented,
which
enable
waste-minimized
(additive-,
oxidant-,
base-free),
efficient
cyclisations/couplings
via
transition
metal
oxide–Bi(
iii
)
cooperative
catalysis.
