Abstract
Cross-dehydrogenative
coupling
between
E—H
bonds
and
Z—H
bonds,
where
E
Z
are
heteroatoms,
can
be
considered
as
a
green
approach
for
the
construction
of
chemical
bonds.
Since
it
avoids
need
prefunctionalization
starting
materials,
this
type
transformation
shorten
synthetic
routes
increase
total
atom
efficiency.
In
context,
such
reactions
recognized
an
efficient
alternative
to
classical
cross-coupling
reactions.
During
past
decades,
cross-dehydrogenative
strategy
has
been
widely
used
synthesizing
various
target
functional
molecules,
great
achievements
have
made
in
carbon—carbon
bond
formation.
recent
years,
also
employed
construct
heteroatom—heteroatom
bonds;
review
covers
advances
field,
with
focus
on
methods
formation
phosphorus—heteroatom
sulfur—heteroatom
Heliyon,
Год журнала:
2023,
Номер
9(12), С. e21153 - e21153
Опубликована: Ноя. 25, 2023
BackgroundRecently,
a
newly
programmed
cell
death
has
been
discovered,
namely
cuproptosis.
It
is
considered
novel
copper-dependent
model.
Long
non-coding
RNA
(lncRNA)
influence
the
prognosis
of
bladder
cancer.
In
this
study,
we
established
scoring
system
based
on
7
cuproptosis-related
lncRNA
to
predict
and
immune
landscape
cancer
(BCa).MethodGene
expression
clinical
data
431
tissues
were
downloaded
from
The
Cancer
Genome
Atlas
(TCGA),
including
19
normal
samples
419
samples.
All
randomly
categorized
into
train
test
cohorts.
Cuproptosis-related
distinguished.
Then
conduct
univariate
COX
multivariate
regression,
paralleled
with
LASSO
regression
cultivate
risk
Kaplan-Meier
curves,
scatter
diagram,
C-index,
ROC
nomogram,
PCA
analysis
Cox
used
accuracy
model
patient
survival.
Additional,
gene
mutation
status
between
high-
low-risk
groups
was
calculated.GO
KEGG
access
DEGs
(different
genes)-related
pathway.The
ssGSEA
ESTIMATE
algorithms
assess
function
in
different
tumor
Besides,
patient's
response
immunotherapy
drug
susceptibility
also
estimated.Results7
(LINC01184,
LINC00513,
LINC02443,
SMARCA5-AS1,
BDNF-AS,
SOD2-OT1,
HYI-AS1)
selected
construct
cohort.
This
can
well
overall
survival
(OS)
group
entire
cohort
stage.
Despite
no
significant
observed
group,
infiltration,
sensitivity
drugs
are
discovered.ConclusionWe
which
outcome
satisfactory
predictive
effects.
provide
new
insight
prognostic
evaluation
may
have
potential
guide
comprehensive
treatment
Phosphorus, sulfur, and silicon and the related elements,
Год журнала:
2023,
Номер
198(10), С. 789 - 799
Опубликована: Июнь 8, 2023
AbstractAbstractPhosphoramides
represent
an
important
class
of
organophosphorus
compounds
that
have
widespread
applications
in
industry,
agriculture,
chemical
synthesis
as
well
biomedicine.
Researchers
conducted
intensive
and
extensive
studies
on
the
properties
synthetic
methods
phosphamides,
including
optimization
improvement
preparative
procedures
expansion
compound
types.
This
paper
presents
overview
classical
recently
reported
for
efficient
construction
P-N
bonds.Graphical
abstractKeywords:
P(O)-N
bondP-N
bondphosphoramiditechiral
phosphonamide
Disclosure
statementThe
author
declares
no
conflict
interest,
financial
or
otherwise.
Abstract
Phenylhydrazines,
comprised
of
a
phenyl
group
attached
with
hydrazine
unit,
contribute
potentially
to
organic
synthetic
transformations.
Because
the
myriad
applications,
last
decade
has
witnessed
considerable
upsurge
interest
perform
various
reactions
catalyzed/mediated/promoted
by
phenylhydrazines.
Some
these
have
shown
high
regioselectivity
in
short
reaction
time
under
mild
conditions.
The
emergence
innumerable
transformations
utilizing
phenylhydrazine
unleashed
numerous
openings
for
development
diverse
heterocyclic
scaffolds.
Given
importance
this
valuable
chemical
entity,
review
highlights
methodologies
Moreover,
present
article
will
considerably
synthesis
as
well
pharmaceutical
chemistry.
Academically,
be
interesting
and
informative
researchers
attempting
develop
new
routes
structures.
Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Июль 26, 2023
Abstract
Background
Cuproptosis
and
ferroptosis
acts
important
defense
for
the
organism
by
preventing
tumor
cells
migration
their
growth.
In
this
study,
cuproptosis
ferroptosis-related
genes
were
used
to
construct
a
prognostic
model
lung
adenocarcinoma
(LUAD)
patients.
Methods
TCGA
database
was
acquire
RNA
sequencing
data
clinical
information
LUAD
samples.
The
Cox
LASSO
regression
analysis
performed
signature.
addition,
GSEA,
GO,
KEGG
investigate
potential
molecular
mechanism.
Moreover,
we
analyzed
relationship
between
our
identified
signature
immune
cell
infiltration,
microenvironment,
immunotherapy
response,
drug
sensitivity
analysis.
Results
Three
prognosis
related
selected
(SRXN1,
GLS2,
SLC2A1).
Finally,
in
vitro
experiments
qRT-PCR,
western
blot,
scratch
test,
colony-formation,
lipid
ROS
validate
expression
function
of
SRXN1
gene.
Conclusion
Combined
with
clinicopathological
characteristics,
risk
validated
as
new
independent
factor
LUAD.
Abstract
Cross-dehydrogenative
coupling
between
E—H
bonds
and
Z—H
bonds,
where
E
Z
are
heteroatoms,
can
be
considered
as
a
green
approach
for
the
construction
of
chemical
bonds.
Since
it
avoids
need
prefunctionalization
starting
materials,
this
type
transformation
shorten
synthetic
routes
increase
total
atom
efficiency.
In
context,
such
reactions
recognized
an
efficient
alternative
to
classical
cross-coupling
reactions.
During
past
decades,
cross-dehydrogenative
strategy
has
been
widely
used
synthesizing
various
target
functional
molecules,
great
achievements
have
made
in
carbon—carbon
bond
formation.
recent
years,
also
employed
construct
heteroatom—heteroatom
bonds;
review
covers
advances
field,
with
focus
on
methods
formation
phosphorus—heteroatom
sulfur—heteroatom
