Chemistry - A European Journal,
Год журнала:
2023,
Номер
29(59)
Опубликована: Авг. 7, 2023
An
unprecedented
enantioselective
organocatalytic
spirocyclization
strategy
is
presented
by
in
situ
generation
of
aminoisobezofulvenes.
The
reaction
sequence
involves
a
reductive
Michael/aldol-condensation/Michael
addition
cascade
iminium-enamine
catalysis.
key
success
this
was
the
formation
intermediatory
nucleophilic
aminoisobenzofuvenes
accountable
for
intramolecular
Michael
addition.
Benzospirononanes
featuring
an
all
carbon
qauternary
spirocenter
were
obtained
using
proline-derived
amino-organocatalyst
moderate
to
good
yields
and
excellent
diastereo-
enantioselectivities
(up
>20
:
1
dr,
99
%
ee).
Post-methodological
manipulation
benzospirononanes
also
demonstrated.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(22), С. 16564 - 16570
Опубликована: Окт. 31, 2024
An
efficient
method
for
phosphine-catalyzed
sulfophosphinoylation
of
α,β-unsaturated
ketones
synthesis
allylic
organophosphorus
compounds
has
been
reported,
in
which
acting
as
zwitterions
react
with
electrophiles
and
nucleophiles
to
form
a
C-P
bond
C-O
obtain
high
regio-
stereoselectivity
moderate
excellent
yields.
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
10(19), С. 4848 - 4853
Опубликована: Янв. 1, 2023
An
efficient
strategy
for
the
enantioselective
construction
of
spirodihydrofuran
oxindoles
with
vicinal
quaternary
stereocenters
was
first
developed
via
a
one-pot
Michael/iodization/S
N
2
nucleophilic
substitution
sequence.
Chemistry - A European Journal,
Год журнала:
2023,
Номер
29(59)
Опубликована: Авг. 7, 2023
An
unprecedented
enantioselective
organocatalytic
spirocyclization
strategy
is
presented
by
in
situ
generation
of
aminoisobezofulvenes.
The
reaction
sequence
involves
a
reductive
Michael/aldol-condensation/Michael
addition
cascade
iminium-enamine
catalysis.
key
success
this
was
the
formation
intermediatory
nucleophilic
aminoisobenzofuvenes
accountable
for
intramolecular
Michael
addition.
Benzospirononanes
featuring
an
all
carbon
qauternary
spirocenter
were
obtained
using
proline-derived
amino-organocatalyst
moderate
to
good
yields
and
excellent
diastereo-
enantioselectivities
(up
>20
:
1
dr,
99
%
ee).
Post-methodological
manipulation
benzospirononanes
also
demonstrated.
