Trifluoromethoxylation/trifluoromethylthiolation/trifluoro- methylselenolation strategy for the construction of heterocycles

Chinese Chemical Letters, Год журнала: 2022, Номер 34(5), С. 108045 - 108045

Опубликована: Дек. 8, 2022

Язык: Английский

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Photo-induced spirocyclization of biaryl ynones with ammonium thiocyanate: access to thiocyanate-featured spiro[5,5]trienones

Green Chemistry, Год журнала: 2022, Номер 25(1), С. 153 - 160

Опубликована: Ноя. 25, 2022

Photo-promoted cascade 6-exo-trig spirocyclization of biaryl ynones with NH 4 SCN was developed for the preparation various SCN-containing spiro[5,5]trienones.

Язык: Английский

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Cascade Radical Trifluoromethylthiolation/Cyclization of Dienes To Access SCF₃-Containing Medium-Sized Heterocycles

Organic Letters, Год журнала: 2023, Номер 25(24), С. 4598 - 4602

Опубликована: Июнь 12, 2023

A novel radical cascade trifluoromethylthiolation/cyclization of dienes (N-alkyl-2-(1-phenylvinyl)aniline derivatives) with AgSCF3 has been developed. This approach provides simple and efficient access to a wide range SCF3-containing medium-sized rings (7/8/9-membered heterocycles). Preliminary mechanistic studies suggest that the reaction is realized through silver-assisted cyclization process. The large-scale experiment modification product reveal promising utility this protocol.

Язык: Английский

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Photochemical difluoromethylation of alkynes: synthesis of CF₂H-substituted seven-membered dioxodibenzothiazepines and dibenzazepines

Organic Chemistry Frontiers, Год журнала: 2023, Номер 10(8), С. 1968 - 1974

Опубликована: Янв. 1, 2023

A general and efficient photochemical strategy for difluoromethylation/radical cascade cyclization of alkynes with sodium difluoromethylsulfinate (NaSO 2 CF H) has been disclosed.

Язык: Английский

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Nitro-Spirocyclization of Biaryl Ynones with tert-Butyl Nitrite: Access to NO₂-Substituted Spiro[5,5]trienones

The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(7), С. 4854 - 4862

Опубликована: Март 22, 2023

A metal/peroxide-free involved simple cascade 6-exo-trig spirocyclization of tert-butyl nitrite with biaryl ynones has been finished, which resulted in various NO2-modified spiro[5,5]trienones good regioselectivity/yields. variety scaled-up experiments, reduction/epoxidation operations, and mechanistic studies were performed to verify the merits process this radical system. Finally, structure spirocycles was confirmed by single-crystal X-ray diffraction.

Язык: Английский

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Metal-free radical bicyclization/chloroalkylarylation of 1,6-enynes with chloroalkanes

Chemical Communications, Год журнала: 2024, Номер 60(29), С. 3938 - 3941

Опубликована: Янв. 1, 2024

A metal-free radical bicyclization of chloralkanes and 1,6-enynes produces various polychlorinated/chlorinated polyheterocycles.

Язык: Английский

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Cascade Oxidative Trifluoromethylthiolation and Cyclization of 3-Alkyl-1-(2-(alkynyl)phenyl)indoles

The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(9), С. 5403 - 5419

Опубликована: Апрель 5, 2023

Persulfate-promoted radical cascade trifluoromethylthiolation and cyclization of 3-alkyl-1-(2-(alkynyl)phenyl)indoles with AgSCF3 were investigated. This protocol provides a novel route to CF3S-substituted indolo[1,2-a]quinoline-7-carbaldehydes indolo[1,2-a]quinoline-7-methanone derivatives via the formation C-SCF3 bond C-C benzylic carbon oxidation in single step. reaction can accommodate broad range functional groups. The single-crystal X-ray diffraction data confirm chemical structure product. A scale-up experiment inhibition experiments operated system. Photophysical properties some selected 5-((trifluoromethyl)thio)indolo[1,2-a]quinoline-7-carbaldehydes studied by UV-visible fluorescence spectroscopy.

Язык: Английский

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Access to SCF3-containing N-fused quinolines via photo-induced domino radical trifluoromethylthiolation

Journal of Catalysis, Год журнала: 2025, Номер unknown, С. 116005 - 116005

Опубликована: Фев. 1, 2025

Язык: Английский

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Crystal structure of 2-chloro-11-(((fluoromethyl)sulfonyl)methyl)-6-methyl-6,11-dihydrodibenzo[c,f][1,2]thiazepine 5,5-dioxide, C₁₆H₁₃ClFNO₄S₂

Zeitschrift für Kristallographie - New Crystal Structures, Год журнала: 2025, Номер unknown

Опубликована: Апрель 23, 2025

Abstract C 16 H 13 ClFNO 4 S 2 , monoclinic, P 1 / c (no. 14), a = 8.9984(2) Å, b 18.0668(6) 10.3178(3) β 95.5070(10)°, V 1669.65(8) Å 3 Z 4, R gt ( F ) 0.0405 wR ref 0.1048, T 150 K.

Язык: Английский

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Recent Progress on the Synthesis of Benzazepine Derivatives via Radical Cascade Cyclization Reactions

Chinese Journal of Organic Chemistry, Год журнала: 2022, Номер 42(12), С. 3979 - 3979

Опубликована: Янв. 1, 2022

Язык: Английский

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