Asian Journal of Organic Chemistry,
Год журнала:
2023,
Номер
13(1)
Опубликована: Дек. 7, 2023
Abstract
A
series
of
tryptamine
derivatives
were
transformed
into
their
corresponding
3‐chloro‐2‐oxidation
products
under
simple
and
mild
conditions.
This
protocol
is
an
operationally
system
that
utilizes
a
single
reagent
SO
2
ClF
plays
dual
role
as
both
oxidant
chloride
source
enables
the
construction
various
3,3‐disubstituted
oxindoles
with
good
functional
group
tolerance.
The
transformations
product
highlight
its
potential
synthetic
applications.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(14), С. 4007 - 4013
Опубликована: Янв. 1, 2024
An
asymmetric
Michael–alkylation
reaction
with
a
reversal
of
enantioselectivity
catalyzed
by
chiral
cobalt
complexes
is
reported,
giving
spiro-cyclopropane-oxindoles
complete
and
controlled
switch
in
stereoselectivity
(up
to
99%
−98%
ee).
The Journal of Organic Chemistry,
Год журнала:
2022,
Номер
87(24), С. 16755 - 16766
Опубликована: Дек. 5, 2022
A
novel
organocatalytic
cascade
approach
for
the
synthesis
of
spiro-cyclopropyl
oxindole
derivatives
has
been
developed.
The
methodology
is
based
on
asymmetric
vinylogous
Michael
addition
4-nitroisoxazole
to
N-Boc
isatylidene
malonates
followed
by
intramolecular
alkylation.
Its
remarkable
stereocontrol,
wide
substrate
scope,
and
scalability
highlight
this
new
developed
strategy.
Moreover,
work
represents
first
example
initiated
ring
closure
(MIRC)
reaction
chiral
3,3′-cyclopropyl
oxindole.
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
10(17), С. 4256 - 4262
Опубликована: Янв. 1, 2023
We
achieved
diverse
transformations
of
α-aryl
vinylsulfonium
salts
under
mild
reaction
conditions,
affording
various
1,2-dihydroquinoline
and
ring-fused
tetrahydroquinoline
skeletons
in
moderate
to
excellent
isolated
yields.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(12), С. 3369 - 3375
Опубликована: Янв. 1, 2024
A
novel
palladium/copper-cocatalyzed
tandem
cyclization
of
o
-alkenyl
arylisocyanides
and
sulfur
ylides
with
alcohols
has
been
developed,
providing
a
simple
efficient
method
for
the
synthesis
spiro
3,3′-cyclopropyl
oxindoles
in
single
step.
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
27(28)
Опубликована: Май 27, 2024
Abstract
A
straightforward
[3+2]
annulation
method
for
synthesizing
bisspiro(oxindole)
derivatives
has
been
developed
by
using
isatin‐derived
Morita‐Baylis‐Hillman
carbonates
and
p
‐quinone
methides
(
‐QMs)
with
4‐dimethylaminopyridine
(DMAP)
as
the
catalyst.
The
optimized
protocol
in
dichloromethane
(DCM)
solvent
achieves
good
yields
(up
to
87
%)
diastereoselectivity
(>20
:
1).
versatility
of
is
shown
through
synthesis
various
derivatives,
including
chiral
variants
up
82
%
ee.
intermediates
were
captured
HRMS,
a
plausible
reaction
pathway
was
proposed.
Organic Letters,
Год журнала:
2022,
Номер
24(46), С. 8553 - 8558
Опубликована: Ноя. 15, 2022
A
cascade
Michael
addition/alkylation
reaction
between
3-chlorooxindoles
and
α-cyano
chalcones
catalyzed
using
a
multifunctional
quinine-derived
aminoindanol-thiourea
substance
was
investigated.
series
of
spirooxindoles
incorporating
densely
substituted
cyclopropane
motif
were
efficiently
obtained
with
moderate
to
excellent
diastereo-
enantioselectivity
further
transformed
products
versatile
structural
diversity.
Density
functional
theory
(DFT)
calculations
indicated
that
the
tentative
intramolecular
hydrogen
bonds
in
chiral
catalyst
crucial
for
stereocontrol.
hormozgan medical journal,
Год журнала:
2024,
Номер
28(1), С. 41 - 48
Опубликована: Янв. 1, 2024
Objectives:
Given
the
spread
of
azole
resistance
in
Candida
albicans
(C.
albicans),
searching
for
new
potent
compounds,
such
as
spirocyclopropane-oxindole
derivatives
is
important.
This
study
evaluates
antifungal
susceptibility
on
clinical
isolates
C.
albicans.
Methods:
Antifungal
50
to
(4a,
4b,
and
4c),
nystatin,
fluconazole
were
evaluated
according
Clinical
Laboratory
Standards
Institute
(M27-S4)
guidelines.
The
medicinal
dilution
range
fluconazole,
nystatin
was
0.256
128,
0.128
64,
0.032
16
μg/mL,
respectively.
minimum
inhibitory
concentration
(MIC)
defined
that
caused
at
least
50%
growth
inhibition
compared
positive
control.
Statistical
analysis
performed
using
SPSS
software,
version
20.
significance
level
set
P≤0.05.
Results:
There
a
significant
difference
between
MIC
values
against
comparison
MICs
4c)
showed
derivative
4a
had
lower
MIC50
(8
μg/mL),
MIC90
(16
Geometric
(G)
Mean
(10.126)
than
4b
(MIC50=64,
MIC90=128,
G
Mean=76.638),
4c
Mean=60.547).
Discussion:
effects
significantly
less
fluconazole.
Therefore,
with
structural
changes,
these
compounds
will
increase.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(23), С. 6666 - 6671
Опубликована: Янв. 1, 2024
A
new
approach
for
constructing
enantiopure
spiroskeletons
was
developed
via
bifunctional
phosphonium
salt-catalyzed
[2
+
1]
annulation.
These
novel
scaffolds
have
potential
to
facilitate
the
discovery
and
development
of
chiral
drugs.
