Опубликована: Ноя. 17, 2022
A tandem annulation reaction of allyl ketones and ethenesulfonyl fluoride has been described. Under the catalysis Brønsted base, vinyl reacted with through a cascade intermolecular Michael addition-intramolecular SuFEx process to afford γ-alkenylated δ-sultones in good excellent yields. In this reaction, no additional base was needed, 4 Å Molecular sieves used as efficient HF scavenger restrict neutralization deactivation catalyst.
Язык: Английский
Organic Chemistry Frontiers, Год журнала: 2023, Номер 10(5), С. 1322 - 1345
Опубликована: Янв. 1, 2023
Functionalization of alkenes/alkynes is a highly effective route to achieve molecular complexity. This review summarizes recent progresses on the 1,2-difunctionalization/hydrofunctionalization unactivated with C−S bond formation.
Язык: Английский
Процитировано
67
Organic Chemistry Frontiers, Год журнала: 2023, Номер 10(10), С. 2416 - 2421
Опубликована: Янв. 1, 2023
An electrophilic sulfenylation promoted oxidation of alkynes is presented, providing the chemo-, regio- and stereoselective synthesis α-sulfenylated α,β-unsaturated aldehydes.
Язык: Английский
Процитировано
8
Organic Letters, Год журнала: 2022, Номер 24(38), С. 7026 - 7030
Опубликована: Сен. 21, 2022
Vinyl triflates are commonly employed as electrophilic vinyl sources in complex synthesis. The triflation of enolates is required for the preparation triflates, generally under strongly basic conditions. Herein, reaction between alkynes and dimethyl(methylthio)sulfonium trifluoromethanesulfonate presented, which leads to development a facile synthesis β-methylthio chemo-, regio-, stereoselective manner neutral extremely simple
Язык: Английский
Процитировано
10
Russian Chemical Reviews, Год журнала: 2023, Номер 92(9), С. RCR5090 - RCR5090
Опубликована: Авг. 6, 2023
The review addresses the applications of pyrroles and compounds based on them in pharmaceutics various branches technology which pyrrole plays a key role. emphasis is put studies that were not covered previous reviews. second part summarizes published data last 15 years synthesis from widely encountered carbonyl compounds, chosen because ready availability possibility varying substituents. This type systematization proposed for first time.<br>The bibliography includes 199 references. references
Язык: Английский
Процитировано
4
Organic & Biomolecular Chemistry, Год журнала: 2022, Номер 21(5), С. 930 - 934
Опубликована: Дек. 28, 2022
Oxidative cross-coupling of two thiols is the most direct tool for synthesis unsymmetrical disulfides and highly desirable across academia industry. However, inevitable formation significant amounts corresponding symmetrical by-products a major issue. We herein present method toward in which homo-coupling effectively inhibited by adding sequentially, taking advantage rapid oxidation thiol bromodimethylsulfonium bromide.
Язык: Английский
Процитировано
6
Organic Letters, Год журнала: 2023, Номер 25(26), С. 4765 - 4769
Опубликована: Июнь 26, 2023
An efficient method for the acid-catalyzed carbosulfenylation of 1,6-diene has been achieved employing N-(aryl/alkylthio)succinimides as a thiolating reagent. The reaction involves generation an episulfonium ion followed by intramolecular trapping with alkenes, which offers access to diverse thiolated dehydropiperidines in good yield. In addition, synthesis dihydropyran and cyclohexene derivatives, well conversion arylthiol moiety useful functional groups, were also demonstrated.
Язык: Английский
Процитировано
1
Asian Journal of Organic Chemistry, Год журнала: 2023, Номер 12(8)
Опубликована: Июль 22, 2023
Abstract Quinolinones and benzo[ c ]azepinones are important cores in biologically active molecules. We report the cyclization of N ‐substituted propynamides, initiated by readily available electrophilic sulfenylating agent, enabling synthesis quinolinones exceedingly simple conditions. The approach shows excellent generality to substrates tolerability functional groups. anti‐inflammatory effect newly synthesized 3‐sulfenyl quinolinone 4‐sulfenyl ]azepinone products tested, two compounds confirmed have inhibitive on TNF‐α expression.
Язык: Английский
Процитировано
1
The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(21), С. 15466 - 15472
Опубликована: Окт. 20, 2023
An unexpected deprotonative process of thiirenium ions is presented, which provides a new synthesis aryl thioalkynes directly from terminal alkynes via the electrophilic activation carbon-carbon triple bonds. The conditions are well compatible with various functional-group-substituted alkynes. direct elimination ion intermediate, or its tautomer, benzyl vinyl carbocation, supported by control experiments and labeling reaction.
Язык: Английский
Процитировано
1
Progress in heterocyclic chemistry, Год журнала: 2023, Номер unknown, С. 199 - 250
Опубликована: Янв. 1, 2023
Язык: Английский
Процитировано
1
Synlett, Год журнала: 2024, Номер 35(17), С. 2032 - 2036
Опубликована: Март 7, 2024
Abstract The electrophilic thiolation of alkenes initiated by DMTSM and the addition CF3SO2Na in one pot has been developed. This reaction also can be extended to ArSO2Na. protocol features a good substrate scope, simple procedures, mild conditions affords desired products moderate yields without metal catalysts.
Язык: Английский
Процитировано
0