Silver(I)-Promoted [3 + 3]-Cycloaddition of 2-(2-Enynyl)quinolines with N′-(2-Alkynylbenzylidene)hydrazides DOI
Feng Li, Qing Yang,

He Li

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(16), С. 11567 - 11575

Опубликована: Авг. 1, 2024

An effective and straightforward Ag(I)-mediated annulation of 2-(2-enynyl)quinolines N'-(2-alkynylbenzylidene)hydrazides was developed, forging various synthetically challenging 17bH-isoquinolino[2'',1'':1′,6']pyridazino[4′,5′:3,4]pyrrolo[1,2-a]quinolines, including different nitrogen-containing fused rings, in moderate to excellent yields. This one-pot cycloaddition strategy features exclusive regioselectivity, high atom economy, broad substrate scope under mild conditions. The practicality reliability this reaction demonstrated by a successful scale-up synthesis.

Язык: Английский

Transition metal-free tunable synthesis of 3-(trifluoromethylthio) and 3-trifluoromethylsulfinyl chromones via domino C-H functionalization and chromone annulation of enaminones DOI
Tao Zhou, Jing Zhou, Yunyun Liu

и другие.

Chinese Chemical Letters, Год журнала: 2024, Номер 35(11), С. 109683 - 109683

Опубликована: Март 2, 2024

Язык: Английский

Процитировано

16
Nanocellulose as Convenient Reaction Media for the FeCl3 Mediated Mechanochemical Synthesis of 3-Acylchromones DOI Creative Commons
Satenik Mkrtchyan, Vishal B. Purohit, Viktor O. Iaroshenko

и другие.

ACS Sustainable Chemistry & Engineering, Год журнала: 2023, Номер 11(38), С. 13877 - 13884

Опубликована: Сен. 11, 2023

A solvent free strategy for the mechanochemical synthesis of 3-acylchromones has been developed via FeCl3-nanocellulose mediated dehydrative coupling ortho-hydroxyarylenaminones and carboxylic acids. The undergo electrophilic domino cyclization followed by an unusual acylation event with acids in presence FeCl3 as catalyst nanocellulose reaction media. protocol was found to be simple, efficient, environmentally benign obtain a diverse array high yields. features advantages such use cheap readily available acyl source no requirement directing groups, oxidants, solvents. Furthermore, utilization wood-derived material, biodegradable media nontoxic iron salt under very mild solvent-free conditions makes this interesting perspective Green Chemistry principles.

Язык: Английский

Процитировано

12
Formal [1 + 2 + 3] Annulation of Anilines and CF3-Containing Ynones via 6π-Electrocyclization DOI Creative Commons
Lili Feng, Shao‐Fei Ni,

Yunfei Lai

и другие.

Precision Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Июнь 5, 2025

Язык: Английский

Процитировано

0
HFIP promoted cyclization of o-hydroxyaryl enaminones with chlorohydrocarbon for synthesis of chromone-containing triarylmethanes DOI
Kai Yang,

Longhui Wu,

Xinlei Fu

и другие.

Tetrahedron, Год журнала: 2024, Номер 156, С. 133948 - 133948

Опубликована: Март 16, 2024

Язык: Английский

Процитировано

2
Base-Promoted Decarboxylative Annulation of Methyl 2-(2-Bromophenyl)acetates and Ynones to Access Benzoxepines DOI
Lulu Chen, Feng Li, Qing Yang

и другие.

The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(5), С. 3079 - 3088

Опубликована: Фев. 17, 2023

A simple and efficient base-mediated decarboxylative annulation of ynones with methyl 2-(2-bromophenyl)acetates has been developed. broad range benzoxepines were prepared a substrate scope high regioselectivity in moderate to excellent yields under transition-metal-free conditions. This method proceeds through tandem [2 + 4] annulation, ring-opening reaction, the intramolecular nucleophilic aromatic substitution reaction. Additionally, key intermediates successfully obtained characterized unambiguously by single-crystal X-ray crystallography, which could favorably support mechanism. Furthermore, gram-scale reaction synthetic applications for further functionalization are also studied.

Язык: Английский

Процитировано

5
Ag(I)-Mediated Annulation of 2-(2-Enynyl)pyridines and Propargyl Amines to Access 1-(2H-Pyrrol-3-yl)indolizines DOI
Feng Li, Qing Yang, Mingyue Liu

и другие.

The Journal of Organic Chemistry, Год журнала: 2023, Номер 89(1), С. 304 - 312

Опубликована: Дек. 21, 2023

An effective Ag(I)-mediated annulation of 2-(2-enynyl)pyridines and propargyl amines was developed, unexpectedly affording a broad range functionalized 1-(2H-pyrrol-3-yl)indolizines in moderate to excellent yields. The developed method is characterized by operational simplicity, ready availability starting materials, high regioselectivity, substrate scope under mild reaction conditions. Ag(I)-promoted cyclization possibly results the formation spiroindolizine, ring-opening rearrangement which may give 1-(2H-pyrrol-3-yl)indolizine. Furthermore, gram-scale synthetic transformations are also studied.

Язык: Английский

Процитировано

4
Silver(I)-Promoted [3 + 3]-Cycloaddition of 2-(2-Enynyl)quinolines with N′-(2-Alkynylbenzylidene)hydrazides DOI
Feng Li, Qing Yang,

He Li

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(16), С. 11567 - 11575

Опубликована: Авг. 1, 2024

An effective and straightforward Ag(I)-mediated annulation of 2-(2-enynyl)quinolines N'-(2-alkynylbenzylidene)hydrazides was developed, forging various synthetically challenging 17bH-isoquinolino[2'',1'':1′,6']pyridazino[4′,5′:3,4]pyrrolo[1,2-a]quinolines, including different nitrogen-containing fused rings, in moderate to excellent yields. This one-pot cycloaddition strategy features exclusive regioselectivity, high atom economy, broad substrate scope under mild conditions. The practicality reliability this reaction demonstrated by a successful scale-up synthesis.

Язык: Английский

Процитировано

0