A
simple
yet
efficient
approach
towards
the
synthesis
of
β-hydroxy
selenylated
ketones
was
developed
from
easily
accessible
chalcones
and
diphenyl
diselenide
through
an
electrochemical
pathway.
In
this
technique,
water
are
source
PhSe.
hydroxyl
(-OH)
groups
that
can
be
inserted
at
α
β
positions
respectively
producing
in
moderate
to
good
yields.
The
reaction
features
difunctionalization
ketones,
catalyst
free,
mild
conditions,
stereo
regioselectivity
undivided
cell
room
temperature.
For
transformation,
a
plausible
radical
mechanism
has
been
put
out.
The Chemical Record,
Год журнала:
2024,
Номер
24(7)
Опубликована: Июль 1, 2024
Abstract
Diorganyl
diselenides
have
emerged
as
privileged
structures
because
they
are
easy
to
prepare,
distinct
reactivity,
and
broad
biological
activity.
They
also
been
used
in
the
synthesis
of
natural
products
an
electrophile
organoselenylation
aromatic
systems
peptides,
reductions
alkenes,
nucleophilic
substitution.
This
review
summarizes
advancements
methods
for
transformations
promoted
by
diorganyl
main
functions
organic
chemistry.
Parallel,
it
will
describe
findings
on
pharmacology
toxicology
diselenides,
emphasizing
anti‐inflammatory,
hypoglycemic,
chemotherapeutic,
antimicrobial
activities.
Therefore,
examination
detailing
reactivity
characteristics
provides
valuable
insights
academic
researchers
industrial
professionals.
A
simple
yet
efficient
approach
towards
the
synthesis
of
β-hydroxy
selenylated
ketones
was
developed
from
easily
accessible
chalcones
and
diphenyl
diselenide
through
an
electrochemical
pathway.
In
this
technique,
water
are
source
PhSe.
hydroxyl
(-OH)
groups
that
can
be
inserted
at
α
β
positions
respectively
producing
in
moderate
to
good
yields.
The
reaction
features
difunctionalization
ketones,
catalyst
free,
mild
conditions,
stereo
regioselectivity
undivided
cell
room
temperature.
For
transformation,
a
plausible
radical
mechanism
has
been
put
out.
