Green synthesis of pyrrolo[1,2-α]quinoxalines by palladium-catalyzed transfer hydrogenation with nitriles as carbon synthons
Journal of Catalysis,
Год журнала:
2023,
Номер
421, С. 156 - 161
Опубликована: Март 15, 2023
Язык: Английский
Recent Progress in the Catalytic Synthesis of Pyrrolo[1,2‐α]quinoxaline
Asian Journal of Organic Chemistry,
Год журнала:
2023,
Номер
12(8)
Опубликована: Июль 3, 2023
Abstract
Pyrrolo[1,2‐
α
]quinoxaline
and
its
derivatives
have
excellent
biological
activity
photoelectric
properties,
are
widely
used
in
the
fields
of
pharmaceutical
preparations
organic
electroluminescence.
This
review
starts
from
catalysts
summarizes
single
metal
catalysis
palladium,
rhodium,
iron,
molybdenum,
copper,
as
well
synergistic
iron
molybdenum
bimetallic
metal‐free
catalytic
systems
for
synthesis
pyrrolo[1,2‐
]quinoxaline.
The
mechanism
different
was
detailly
introduced
analysed.
By
analysing
advantages
disadvantages
existing
catalyst
systems,
prospects
new
methods
presented.
Язык: Английский
A Direct Method for Synthesis of Quinoxalines and Quinazolinones Using Epoxides as Alkyl Precursor
Molecules,
Год журнала:
2023,
Номер
28(21), С. 7391 - 7391
Опубликована: Ноя. 2, 2023
An
iodine-mediated
one-pot
synthesis
of
pyrrolo/indolo
[1,2-a]quinoxalines
and
quinazolin-4-one
via
utilizing
epoxides
as
alkyl
precursors
under
metal-free
conditions
has
been
described.
Both
1-(2-aminophenyl)-pyrrole
2-aminobenzamide
could
be
applied
to
this
protocol.
A
total
33
desired
products
were
obtained
with
moderate
good
yields.
This
methodology
was
suitable
for
wide-scale
preparation
the
further
modified
into
promising
pharmaceutically
active
reagents.
Язык: Английский
A General Method for Elemental Sulfur Promoted Synthesis of Ortho‐Substituted Pyrrolo[1,2‐a]quinoxalin‐4‐yl Anilines
ChemistrySelect,
Год журнала:
2024,
Номер
9(17)
Опубликована: Май 2, 2024
Abstract
Synthesis
of
heteroaryl
ortho
‐substituted
anilines
is
hitherto
challenging.
Herein
we
report
scope
and
limitation
method
for
annulation
1‐(2‐nitroaryl)pyrroles
derivatives
2‐aminobenzyl
alcohol
to
afford
pyrrolo[1,2‐
a
]quinoxalin‐4‐yl
anilines.
Reaction
conditions
contained
elemental
sulfur
as
promoter,
while
were
tolerant
wide
range
aryl
amines.
Our
would
offer
feasible
tactic
yield
steric
bulk
with
heterocyclic
substituents.
Язык: Английский
Direct C–C Bond Cleavage of CH3CN as a Single‐Carbon Synthon：Synthesis of Pyrrolo[1,2‐a]quinoxalines via Electrochemical Oxidation
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(22), С. 4649 - 4653
Опубликована: Авг. 20, 2024
Abstract
A
direct
electrochemical
redox
reaction
involving
radical
cross‐coupling
cyclization
for
the
synthesis
of
pyrrolo[1,2‐
a
]quinoxaline
derivatives
from
1‐(2‐aminophenyl)pyrroles
and
CH
3
CN
has
been
developed,
which
includes
functionalization
C(
sp
)−H
bonds
as
well
construction
C−C
C−N
bonds.
Notably,
control
deuterium‐labelling
experiments
suggest
that
in
this
acts
both
carbon
source
via
cleavage
solvent.
The
features
metal‐
oxidant‐free
conditions,
various
substituted
were
obtained.
Язык: Английский
Transition‐Metal‐Free (Hetero)arylsulfonylation of 1‐Iodopyrrolo[1,2‐a]quinoxalines
ChemistrySelect,
Год журнала:
2024,
Номер
9(26)
Опубликована: Июль 10, 2024
Abstract
We
describe
herein
a
method
for
transition‐metal‐free
(hetero)arylsulfonylation
of
1‐iodopyrrolo[1,2‐
]quinoxalines
with
sodium
arylsulfinates.
The
corresponding
aryl
iodides
were
in
situ
prepared
from
eletrophilic
iodination
C1−H
bonds
pyrrolo[1,2‐
N
‐iodosuccinimide.
ensuing
sulfonylation
only
required
DMSO
as
solvent
and
completed
after
15
min.
Many
arylsulfinates
bearing
chloro,
bromo,
methylsufonyl,
acetamide,
nitro
groups
competent
substrates.
Heteroarylsulfonylation
also
feasible.
Язык: Английский