Butyl (2,2-Dibutoxybutanoyl)-ʟ-Tryptophanate

Molbank, Год журнала: 2024, Номер 2024(1), С. M1794 - M1794

Опубликована: Март 19, 2024

The multicomponent reaction between ʟ-tryptophan 1, 2-oxobutanoic acid 2, and 1-butanol in the presence of SiMe3Cl was studied using microwave irradiation conditions. main product identified as an unreported acetal-containing compound, namely, butyl (2,2-dibutoxybutanoyl)-ʟ-tryptophanate (3), yielding 89%. NMR experiments demonstrated that adjacent methylene protons acetal group appeared two signals exhibiting their behavior diastereotopic protons. DFT/B3LYP calculations revealed asymmetric molecular structure with specific angles, leading to explanation results. calculated chemical shifts showed slight differences experimental values suggested magnetic anisotropy inductive deprotection around hydrogen atoms location. mechanism proposed which plays a crucial role by promoting water removal through key steps.

Язык: Английский

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Study on the preparation of amino Salix powder and its adsorption properties for chlortetracycline

Biomass Conversion and Biorefinery, Год журнала: 2024, Номер unknown

Опубликована: Апрель 16, 2024

Язык: Английский

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Diethyl Mesoxalate, A Representative Tricarbonyl Compound – A Useful Synthetic Tool Possessing Diverse Reactivities

European Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Авг. 26, 2024

Abstract Diethyl mesoxalate, a vicinal tricarbonyl compound, possesses multiple functionalities that facilitate diverse chemical conversions. The central carbonyl group with two ester exhibits high electrophilicity to accept nucleophilic attacks of various reagents. This unusual enables the reaction acid amides are not common nucleophiles in organic syntheses. Condensation active methylene compounds or amines leads electron‐deficient alkenes and imines, respectively, which can be transformed into more complex polyfunctionalized by second addition. Chemical transformations between adjacent carbonyls furnish new ring systems useful material pharmaceutical sciences. also built system reacting reagents possessing electrophilic sites. Furthermore, serves as dienophile undergoes cycloaddition form functionalized heterocyclic single step.

Язык: Английский

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Synthesis of tricarbonylated propargylamine and conversion to 2,5-disubstituted oxazole-4-carboxylates

Beilstein Journal of Organic Chemistry, Год журнала: 2024, Номер 20, С. 2827 - 2833

Опубликована: Ноя. 6, 2024

The

Язык: Английский

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