Progress in heterocyclic chemistry, Год журнала: 2024, Номер unknown, С. 309 - 354
Опубликована: Янв. 1, 2024
Язык: Английский
Progress in heterocyclic chemistry, Год журнала: 2024, Номер unknown, С. 309 - 354
Опубликована: Янв. 1, 2024
Язык: Английский
Chemistry - A European Journal, Год журнала: 2024, Номер 30(31)
Опубликована: Март 28, 2024
Abstract Photoinduced aryl radical generation is a powerful strategy in organic synthesis that facilitates the formation of diverse carbon‐carbon and carbon‐heteroatom bonds. The synthetic applications photoinduced complex compounds, including natural products, physiologically significant molecules, functional materials, have received immense attention. An overview current developments production methods their uses given this article. A generalized idea how to choose reagents approach for radicals described, along with techniques associated mechanistic insights. Overall, article offers critical assessment results as well selection reaction parameters specific context cascades, cross‐coupling reactions, functionalization, selective C−H functionalization substrates.
Язык: Английский
Процитировано
16Chemistry - An Asian Journal, Год журнала: 2024, Номер 19(14)
Опубликована: Май 8, 2024
The beginning of photochemical reactions revolutionized synthetic chemistry through sustainable practices. This review explores cutting-edge developments in leveraging light-induced processes for generating cascaded C-C and C-hetero bonds without catalysts. Significantly, catalyst-free photoinduced methodologies have garnered considerable attention, especially the creation varied heterocyclic frameworks drug design synthesis natural products. article delves into underlying mechanisms, addresses limitations, evaluates various methodologies, emphasizing potential photocatalyst transition metal-free to enhance sustainability. Divided two sections, it covers recent strides C-heteroatom multiple bond formation reactions.
Язык: Английский
Процитировано
5Tetrahedron Letters, Год журнала: 2025, Номер unknown, С. 155629 - 155629
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0Topics in heterocyclic chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Май 14, 2025
Thianthrenium salts have emerged as one of the most versatile reagents, gaining significant popularity within synthetic community for their utility in construction C-C and C-X (X = N, O, S, P, halogens) bonds. The use photoredox transition metal catalysis with thianthrenium C-heteroatom bond formation is well established. However, these methods require elevated temperatures, expensive catalysts, ligands under stringent conditions effective execution. In contrast, photocatalysis- transition-metal-free approaches constructing bonds using salt derivatives become increasingly sought after. this regard, electron-donor-acceptor (EDA)-complex reactions a powerful strategy organic synthesis, eliminating need photocatalysts visible light irradiation. EDA-complex photochemistry exploits electron-acceptor properties salts, facilitating rapid generation radical intermediates via C-S cleavage. These play pivotal role enabling variety valuable formations. Perspective, we highlight advances EDA-complex-mediated involving mechanisms, substrate scope, limitations For sake brevity, article organized into five main sections: (1) Nitrogen-based donor reactions, (2) Oxygen-based (3) Sulfur-based (4) Phosphorus-based (5) π-based focus on C-C, C-S, C-B C-P
Язык: Английский
Процитировано
0The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(19), С. 14140 - 14155
Опубликована: Сен. 18, 2023
A radical sulfonation–ipso-cyclization cascade promoted by Mn(OAc)3·2H2O using functionalized alkynes or alkenes and potassium metabisulfite (K2S2O5) is reported. total of 30 spirocyclic sulfonates were synthesized under mild conditions. We also demonstrate a modular synthesis approach in multiple steps for the preparation various azaspiro[4,5]-trienone-based sulfonamides sulfonate esters.
Язык: Английский
Процитировано
7Tetrahedron Letters, Год журнала: 2023, Номер 129, С. 154757 - 154757
Опубликована: Сен. 17, 2023
Язык: Английский
Процитировано
4Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(8), С. 1899 - 1903
Опубликована: Март 1, 2024
Abstract A visible light‐mediated strategy for the preparation of aromatic stannanes from aryl halides (mostly bromides) is presented herein. The reaction proceeds under metal‐ and additive‐free conditions exhibits a broad substrate scope. products obtained have been employed in C−C bond formation via Stille cross‐coupling reactions. Mechanistic investigation evidenced key role both radical trimethylstannyl Ar−Sn formation.
Язык: Английский
Процитировано
1Advanced Synthesis & Catalysis, Год журнала: 2024, Номер unknown
Опубликована: Авг. 22, 2024
Abstract 2‐(chalcogen)benzothiazoles are frequently used as core structures for the development of pharmaceutical agents. A strategy synthesis under electrooxidative conditions using isocyanides, thiols or diselenides substrates was developed. This protocol allows access to structurally diverse in good yields and with functional group tolerance, which does not require heavy metal catalysts exogenous oxidants. Furthermore, gram‐scale performed demonstrate scale‐up applicability this reaction.
Язык: Английский
Процитировано
1European Journal of Organic Chemistry, Год журнала: 2024, Номер 27(41)
Опубликована: Авг. 6, 2024
Abstract A visible‐light‐induced photoredox‐catalyzed radical tandem cyclization of o ‐isocyanodiaryl amines with arylthiodifluoroalkyl 2‐pyridyl sulfones or difluormethyl bromides has been realized for the first time. The reaction works a broad range substrates and provides simple efficient method synthesis 11‐difluoromethyl‐substituted dibenzodiazepines from easily available starting materials in very mild conditions.
Язык: Английский
Процитировано
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