Advanced Synthesis & Catalysis,
Год журнала:
2023,
Номер
365(9), С. 1442 - 1448
Опубликована: Апрель 13, 2023
Abstract
One‐pot
(CF
3
CO)
2
O/K
CO
‐mediated
tandem
cyclocondensation
of
β‐ketosulfones
with
carboxylic
acids
provides
diversified
3‐sulfonylchromones
in
good
to
excellent
yields
by
refluxing
MeCN
under
high‐pressure
(using
a
sealed
tube)
and
dry‐nitrogen
atmospheric
conditions.
This
study
proposed
discussed
plausible
mechanism.
The
paper
also
described
the
formation
3‐sulfonylflavones
gram‐scale
synthesis
3‐sulfonylchromones.
Various
combinations
anhydrides
bases‐promoted
reaction
conditions
were
investigated
for
(4+2)
annulation
via
one
carbon‐oxygen
(C−O)
bond
carbon‐carbon
(C=C)
formations.
magnified
image
Organic Letters,
Год журнала:
2024,
Номер
26(23), С. 4980 - 4985
Опубликована: Июнь 4, 2024
An
unprecedented
selective
chromone
annulation
reaction
controlled
by
solvent
for
the
divergent
synthesis
of
two
types
2,3-disubstituted
skeletons
has
been
developed.
A
variety
2-chromonyl-3-hydrazono-chromones
and
2-alkoxy-3-hydrazono-chromones
were
constructed
efficiently
from
readily
available
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
10(19), С. 4843 - 4847
Опубликована: Янв. 1, 2023
An
unprecedented
dual
α,β-C(sp
2
)–H
functionalization/bicyclization
strategy
of
o
-hydroxyphenyl
enaminones
for
the
preparation
chromeno[2,3-
b
]pyrrol-4(1
H
)-ones
has
been
established.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(12), С. 8632 - 8640
Опубликована: Июнь 6, 2024
Herein,
we
disclosed
a
highly
efficient
pathway
toward
3-selenylated
chromone
derivatives
via
electrocatalytic
cascade
selenylation/cyclization/deamination
of
2-hydroxyaryl
enaminones
with
diselenides.
This
method
showed
mild
conditions,
easy
operation,
wide
substrate
scope,
and
good
functional
group
tolerance.
Furthermore,
this
electrosynthesis
strategy
was
amendable
to
scale-up
the
reaction.
Additionally,
preliminary
experiments
revealed
that
reaction
probably
proceeded
cation
instead
radical
pathway.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(17), С. 3670 - 3675
Опубликована: Июль 2, 2024
Abstract
With
an
in
situ
C−H
iodination
tactic,
a
method
for
the
synthesis
of
chromone‐3‐phosphonates
was
developed
with
trialkyl/triaryl
phosphites
as
reaction
partners
o
‐hydroxyphenyl
enaminones
by
palladium
catalysis.
The
product
formation
consists
cascade
iodination,
chromone
annulation,
and
Arbuzov‐type
C−P
cross
coupling
major
transformations.
In
addition
to
providing
enaminone‐based
synthetic
chromone‐3‐phosphonates,
work
shows
advantage
step
economy
skipping
separate
operation
preparing
iodo‐functionalized
intermediate.
Synthetic Communications,
Год журнала:
2024,
Номер
54(18), С. 1523 - 1550
Опубликована: Авг. 28, 2024
The
chemical
transformations
of
substituted
chromones
1a–c
were
examined
toward
some
nucleophiles
namely
dimedone
(R1),
4-hydroxycoumarin
(R2)
and
4-hydroxy-1-methylquinolin-2(1H)-one
(R3).
DFT
computation
at
the
B3LYP/6-311
G(d,p)
level
theory
was
used
to
perform
theoretical
computations
for
produced
compounds.
HOMO
LUMO
analyses
performed
determine
electronic
charge
distribution
reactivity
molecules.
Molecular
electrostatic
potential
(MEP)
surface
analysis
utilized
predict
molecule's
reactive
sites.
Moreover,
studied
compounds
showed
NLO
characteristics,
where
they
have
first
order
hyperpolarizability
greater
than
urea.
In
addition,
GIAO
method
estimate
1H-NMR
13C-NMR
shifts;
findings
compared
with
experimental
values.
Testing
generated
antibacterial
anticancer
activities
revealed
varied
degrees
inhibitory
effect.
According
Lipinski,
Veber,
Egen
rules,
these
exhibit
physicochemical
properties.
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
27(28)
Опубликована: Май 1, 2024
Abstract
An
electrochemical
decarboxylative
addition
of
N
‐substituted
glycines
to
enaminones
has
been
developed
and
conducted
under
oxidant‐,
catalyst‐,
light‐free
conditions
in
acetonitrile
at
room
temperature
by
using
electron
as
the
traceless
oxidant,
which
provided
a
green
approach
access
C3‐aminomethyl
chromones.
The
resulting
products
were
formed
through
radical
addition/oxidation/cyclization
or
electrophilic
addition/cyclization
pathway
could
act
valuable
building
blocks
construct
polysubstituted
pyrimidine
derivatives.
