Опубликована: Янв. 1, 2023

A novel pyridyl-thiadiazole ligand has been designed, synthesized, and employed in the preparation of a heterogeneous iridium catalyst supported on multi-hydroxyl polyhedral oligomeric silsesquioxane. The as-prepared exhibits excellent catalytic activity one-pot cascade selective synthesis N-/C-substituted indole derivatives from amino alcohols via borrowing hydrogen strategy. Meanwhile, it was observed that this approach good functional group tolerance broad substrate scope. Notably, by employing system, an inhibitor against gp41-mediated HIV-1 fusion core structure could be conveniently synthesized 2-aminophenethyl alcohol benzyl 40.6% total yield for only four steps “borrowing hydrogen” Mechanistic explorations showed transformation undergoes processes, involving N/C-alkylation through strategy, oxidative cyclization. Recycling experiments disclosed easily recovered reused at least seven times with TON.

Язык: Английский