The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 28, 2024
An
amine-promoted
three-component
radical
selenofunctionalization
reaction
of
alkenes
with
TBHP
and
diselenide
is
disclosed.
The
conditions
are
mild
suitable
for
a
wide
range
substrates
(29
examples),
all
give
the
corresponding
hydroxyselenenylation
products
in
moderate
to
excellent
yields.
In
addition,
preliminary
studies
on
mechanism
reveal
that
current
method
might
proceed
via
pathway.
serves
as
both
initiator
source
hydroxyl
group.
European Journal of Medicinal Chemistry,
Год журнала:
2024,
Номер
275, С. 116556 - 116556
Опубликована: Июнь 5, 2024
Azepanes
or
azepines
are
structural
motifs
of
many
drugs,
drug
candidates
and
evaluated
lead
compounds.
Even
though
compounds
having
N-heterocyclic
7-membered
rings
often
found
in
nature
(e.g.
alkaloids),
the
natural
this
group
rather
rare
as
approved
therapeutics.
Thus,
recently
studied
azepane
azepine-congeners
predominantly
consist
semi-synthetically
synthetically-obtained
scaffolds.
In
review
a
comparison
drugs
investigated
leads
was
proposed
taking
into
regard
their
aspects
(stereochemistry),
biological
activities,
pharmacokinetic
properties
confirmed
molecular
targets.
The
N-heterocycles
reveal
wide
range
not
only
against
CNS
diseases,
but
also
e.g.
antibacterial,
anticancer,
antiviral,
antiparasitic
allergy
agents.
As
most
potential
structures,
belonging
to
N-heterocycles,
synthetic
scaffolds,
report
reveals
different
efficient
metal-free
cascade
approaches
useful
synthesize
both
simple
azepine-containing
congeners
those
oligocyclic
structures.
Stereochemistry
azepane/azepine
fused
systems,
view
data
binding
with
targets,
is
discussed.
Apart
from
we
compare
advances
SAR
studies
(mainly
2018
2023),
whereas
related
part
concerning
various
domino
strategies
focused
on
last
ten
years.
Chemical Communications,
Год журнала:
2024,
Номер
60(36), С. 4834 - 4837
Опубликована: Янв. 1, 2024
A
convenient
method
for
oxidant-promoted
radical
cascade
acylation
or
decarbonylative
alkylation
of
1,7-dienes
with
aldehydes
the
construction
tetracyclic
N-containing
skeletons
has
been
established.
SynOpen,
Год журнала:
2023,
Номер
07(04), С. 511 - 520
Опубликована: Окт. 1, 2023
Abstract
Electrochemical
synthesis,
due
to
its
environmentally
benign,
sustainable,
and
practical
nature,
has
become
an
appealing
powerful
substitute
for
traditional
methods
oxidizing
reducing
organic
compounds.
Thus,
numerous
valuable
changes
have
been
established
in
the
field
of
synthesis
through
utilization
electrochemistry.
Among
these
electrochemical
transformations,
formation
C–Se
bonds
stands
out
as
exceptionally
noteworthy
reaction
type.
In
this
graphical
review,
we
present
a
succinct
summary
progress
utilizing
strategies
synthesizing
organoselenium
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(5), С. 1212 - 1217
Опубликована: Янв. 20, 2024
Abstract
A
visible‐light‐induced
selenocyclization
of
ortho
‐vinylanilides
to
4
H
‐3,1‐benzoxazines
has
been
developed
under
controlled
O
2
atmosphere.
The
low
content
in
reaction
medium
promotes
the
aerobic
selenol
oxidation
diselenides
for
full
use
equiv.
selenyl
radicals
a
redox‐neutral
way,
avoiding
higher
content.
visible
light‐induced
utilizes
only
light
with
content,
eliminating
exogenous
photocatalyst
and
chemical
oxidant.
Reviews in Inorganic Chemistry,
Год журнала:
2024,
Номер
44(3), С. 323 - 337
Опубликована: Фев. 16, 2024
Abstract
In
the
last
few
decades,
photochemistry
has
great
influence
on
all
type
of
synthetic
processes.
While
photochemical
synthesis
is
emerging
field
in
inorganic
chemistry
as
it
impart
various
magnificent
properties
to
materials
that
are
used
for
nano-sized
giant
supramolecular
structures.
There
many
based
approaches
like
electron,
atom,
energy
transfer
depending
upon
need
product
where
one
can
switch
pathway.
A
variety
compounds
have
been
synthesized
dienes,
nitrides,
indoles,
gold
nano-particles
and
structures
using
route.
Photochemical
applications
artificial
photosynthesis
fluorophores.
Abstract
A
practical
electrochemical
method
for
the
synthesis
of
β‐hydroxyselenides
has
been
developed
under
an
external
oxidant‐free
condition
at
room
temperature
air
from
alkenes
with
diselenides
and
H
2
O.
radical
mechanism
is
proposed
this
transformation
gram‐scale
reactions
demonstrate
practicability
reaction.
Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
42(19), С. 2323 - 2328
Опубликована: Май 22, 2024
Comprehensive
Summary
A
novel
visible‐light‐induced
radical
cascade
6‐
endo
cyclization
of
dienes
(
N
‐(2‐vinylphenyl)acryl
amides)
is
developed
utilizing
α‐carbonyl
bromides
as
alkyl
reagents.
This
approach
affords
an
efficient
way
for
synthesizing
six‐membered
benzo‐fused
lactam
derivatives
with
chemo‐
and
regio‐selectivity
good
functional
group
tolerance.
Primary,
secondary,
tertiary
are
well‐compatible
this
reaction.
Chemical Communications,
Год журнала:
2024,
Номер
60(74), С. 10156 - 10159
Опубликована: Янв. 1, 2024
An
efficient
chalcogenative
annulation
strategy
for
constructing
functionalized
saturated
N-heterocycles
from
unactivated
alkenes
with
dichalcogenides
under
electrochemical
conditions
has
been
presented.
This
protocol
is
applicable
to
mono-,
di-
or
tri-substituted
alkenes,
providing
a
straightforward
pathway
aziridines,
azetidines,
pyrrolidines,
and
piperidines
high
regioselectivity.
Moreover,
the
qualified
realize
oxychalcogenation
of
as
well.
