Angewandte Chemie,
Год журнала:
2024,
Номер
136(44)
Опубликована: Июль 30, 2024
Abstract
This
Minireview
examines
a
selection
of
case
studies
that
showcase
distinctive
and
enabling
electrochemical
approaches
have
allowed
for
the
generation
reaction
carbocation
intermediates
under
mild
conditions.
Particular
emphasis
is
placed
on
progress
has
been
made
in
this
area
organic
synthesis
polymer
chemistry
over
past
decade.
Advanced Energy Materials,
Год журнала:
2024,
Номер
14(28)
Опубликована: Фев. 21, 2024
Abstract
Electrocatalytic
C−N
couplings
are
promising
alternatives
to
construct
bonds
and
synthesize
vital
chemicals,
including
amine,
amide,
amino
acid,
oxime,
imine,
nitrile,
under
ambient
conditions.
In
recent
years,
the
electrocatalytic
coupling
has
attracted
a
wide
range
of
research
interest
achieved
considerable
developments.
Here,
is
systematically
reviewed
aiming
at
reductive
cathode
oxidative
anode.
cathodic
part,
reaction
systems,
corresponding
design
principles
electrocatalysts
for
different
mechanism
studies
from
experimental
theoretical
aspects,
application‐oriented
devices
summarized.
Anodic
offers
potential
approach
replace
conventional
energy‐demand
synthesis
protocols,
an
indispensable
part
green
controllable
construction
unsaturated
C
=
N
C≡N
bonds.
According
principle
that
electron
transfer
crucial
point
in
anodic
coupling,
reactions
sorted
out
based
on
direct
indirect
paths,
respectively.
Finally,
challenges
outlooks
this
field
proposed.
appealing
topic
electrochemistry
possesses
infinite
possibilities
future.
Advanced Synthesis & Catalysis,
Год журнала:
2023,
Номер
365(19), С. 3375 - 3381
Опубликована: Авг. 23, 2023
Abstract
Electrochemical
amidation
of
the
C(
sp
2
)−H
and
3
bonds
broad
spectrum
arenes
toward
direct
synthesis
anilides
N
‐benzylamides
under
mild
conditions
(room
temperature,
ambient
pressure)
in
absence
metal
catalyst
external
oxidizing
agents
using
nitriles
RCN
(R=Me,
Et)
as
amide
source
is
described.
This
electrochemical
approach
features
moderate
to
high
yields,
a
scope
with
different
functional
groups
amenable
gram
scale
synthesis.
The
key
role
hydroxyl
radical
inductor
generated
during
oxidation
water
fixed
by
spin
trap
EPR
experiment
has
been
established.
Current Research in Green and Sustainable Chemistry,
Год журнала:
2024,
Номер
8, С. 100406 - 100406
Опубликована: Янв. 1, 2024
Atom-economical,
eco-efficient,
metal-
and
chemical
oxidant-free
formation
of
C–C
C–N
bond
from
C(sp2)−H
C(sp3)−H
arenes
toward
the
direct
synthesis
biaryls
anilides
or
N-benzylamides
under
mild
electro-oxidative
conditions
is
described.
The
products
coupling
are
obtained
in
up
to
88%
yields.
Aromatic
substrates
that
oxidized
at
potentials
less
positive
than
+2
V
have
bulky
bromine
iodine
substituents
undergo
homo-coupling
reactions
by
anodic
oxidation
form
dimers.
difficult
oxidize
(Eox
>
V)
preferentially
upon
oxidation.
presence
a
chlorine
substituent
on
aromatic
ring
leads
both
during
electro-oxidation.
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(37), С. 7537 - 7548
Опубликована: Янв. 1, 2024
With
the
development
of
organic
electrochemical
synthesis,
a
series
notable
achievements
have
been
made
in
Ritter
amination
reactions,
which
enriched
methods
available
for
constructing
C-N
bonds.
In
this
review,
reactions
are
introduced
based
on
classification
reaction
substrates,
including
olefins,
aromatics,
alkylbenzenes,
and
less
reported
carboxylic
acids,
ketones,
sulfides,
alkanes.
The
application
technology
to
has
improved
harsh
conditions
traditional
extended
substrate
scope
structural
diversity
products.
value
synthesis
also
further
expanded.
An
iron-catalyzed
chemo-
and
site-selective
benzylic
C-H
bromination
has
been
described.
The
practical
approach
uses
the
substrate
as
limiting
reagent
commercially
available
iron(II)
bromide
at
a
loading
of
1
mol
%
catalyst
without
involvement
any
extrinsic
ligand.
simple
mild
reaction
can
be
readily
scaled
up
to
gram
quantity
with
good
functional
group
tolerance,
offering
convenient
route
for
late-stage
diversification
complex
bioactive
natural
products
pharmaceutical
molecules
through
sequential
bromination.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(44)
Опубликована: Июль 30, 2024
Abstract
This
Minireview
examines
a
selection
of
case
studies
that
showcase
distinctive
and
enabling
electrochemical
approaches
have
allowed
for
the
generation
reaction
carbocation
intermediates
under
mild
conditions.
Particular
emphasis
is
placed
on
progress
has
been
made
in
this
area
organic
synthesis
polymer
chemistry
over
past
decade.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
In
this
work,
we
describe
a
mild
electro-oxidative
metal-,
oxidant-
and
acid-free
direct
amidation
of
aromatic
C–H
bonds
using
nitrile
solvents
as
source
amide
amine
moieties.
IOP Conference Series Earth and Environmental Science,
Год журнала:
2024,
Номер
1419(1), С. 012021 - 012021
Опубликована: Дек. 1, 2024
Abstract
Amide
bonds
are
prevalent
in
peptides,
synthetic
polymers,
insecticides,
and
pharmaceuticals.
These
play
a
critical
role
medicinal
chemistry
due
to
their
stability,
ability
interact
with
biological
targets,
flexibility
designing
bioactive
compounds.
Many
methods
have
been
devised
date
for
the
synthesis
of
amides,
however
majority
them
rely
on
coupling
agents
an
excess
bases
neutralize
acid
produced
during
reaction.
techniques
low
atom
economy
generate
lot
waste,
making
unfriendly
environment.
Greener
chemical
developed
as
result
growing
worldwide
awareness
environmental
issues
drive
towards
sustainability.
In
this
context,
new
approaches
being
based
concepts
green
sustainable
chemistry,
particularly
through
emerging
research
utilizing
organic
electrosynthesis.
This
review
aims
demonstrate
application
amide
electrosynthesis
pathway
development
future