Advances in synthesis and biological activities of quinazoline scaffold analogues: A review

Arabian Journal of Chemistry, Год журнала: 2023, Номер 16(10), С. 105190 - 105190

Опубликована: Июль 28, 2023

Creating effective, ecologically friendly, and commercially viable synthetic routes is crucial in the design synthesis of organic substances. Quinazoline, a heterocyclic compound with nitrogen,is one most significant motifs diverse chemical reactivities many biological applications. Its derivatives comprise family fused heterocycles over 200 naturally occurring alkaloids. Over past few decades, newer, more complex drugs containing quinazolinone structures have been discovered, enormous progress designing various efficient protocols to construct these pharmacologically active scaffolds. This review evaluated recently investigated for synthesizing quinazolines their (from 2017-2023 till date). The current paper provides an up-to-date description recent advancements straightforward procedures that result creation quinazoline molecules. In addition, therapeutical activities numerous quinazoline-based were briefed assessed this review. We envisage information would assist researchers novel analogues as lead compounds.

Язык: Английский

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A Systematic Review of Synthetic and Anticancer and Antimicrobial Activity of Quinazoline/Quinazolin‐4‐one Analogues

ChemistryOpen, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Abstract Quinazolines/quinazolin‐4‐ones are significant nitrogen‐containing heterocycles that exist in various natural products and synthetic scaffolds with diverse medicinal pharmacological applications. Researchers across the globe have explored numerous strategies to develop safer more potent quinazoline/quinazolinone analogues, particularly for combating cancer microbial infections. This review systematically examines scholarly efforts toward understanding this scaffold's pathways relevance, emphasizing role of metal non‐metal catalysts other reagents their synthesis. Additionally, article discusses selected compounds’ anticancer antimicrobial properties, a brief look into structure‐activity relationships.

Язык: Английский

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Recent advances in the investigation of the quinazoline nucleus and derivatives with potential anticancer activities

Future Medicinal Chemistry, Год журнала: 2025, Номер unknown, С. 1 - 19

Опубликована: Май 30, 2025

Diseases such as cancer, neurodegenerative and cardiovascular disorders, diabetes are becoming more common, raising global concerns about prevention treatment. An abnormality in cell growth can lead to the formation of tumors or neoplasms. Cancer is a public health problem always requires further advances field due obstacles that arise during This review explores role new quinazolines their derivatives potential anticancer agents, with variety biological targets. It current addresses discovery molecules go beyond just studies covered here. Studies have shown not past, but still enormous scope for structural modification should be studied than they already are. There clear evidence wide applicability fields oncology medicinal chemistry. The reported here inform corroborate narrative we cannot forget quinazoline nucleus has huge activities and, among them, activity.

Язык: Английский

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Six-membered ring systems: Diazines and benzo derivatives

Progress in heterocyclic chemistry, Год журнала: 2024, Номер unknown, С. 355 - 393

Опубликована: Янв. 1, 2024

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