Polyhydroquinoline Derivatives for Diabetic Management: Synthesis, in Vitro and in Silico Approaches
Future Medicinal Chemistry,
Год журнала:
2023,
Номер
15(23), С. 2195 - 2208
Опубликована: Ноя. 24, 2023
Background:
Medication
used
to
treat
Type
2
diabetes
by
decreasing
the
absorption
of
carbohydrates
in
intestine
consists
α-glucosidase
inhibitors.
Polyhydroquinoline
derivatives
have
attracted
interest
as
excellent
antidiabetic
agents.
Methods:
(1–17)
were
synthesized
and
tested
for
vitro
inhibitory
activity.
Results:
All
compounds
exhibited
good
activity,
having
IC50
values
from
1.23
±
0.03
73.85
0.61
μM,
compared
with
standard
drug,
acarbose.
The
binding
mechanism
these
was
deduced
docking
studies
indicated
that
a
slight
variation
orientation
compounds,
affects
their
capability.
Conclusion:
In
order
find
new
drugs,
this
study
has
discovered
prospective
lead
candidates.
Язык: Английский
Hypervalent iodine-mediated intramolecular alkene halocyclisation
Beilstein Journal of Organic Chemistry,
Год журнала:
2024,
Номер
20, С. 3113 - 3133
Опубликована: Ноя. 28, 2024
The
chemistry
of
hypervalent
iodine
(HVI)
reagents
has
gathered
increased
attention
towards
the
synthesis
a
wide
range
chemical
structures.
HVI
are
characterized
by
their
diverse
reactivity
as
oxidants
and
electrophilic
reagents.
In
addition,
they
inexpensive,
non-toxic
considered
to
be
environmentally
friendly.
An
important
application
is
halogenated
cyclic
compounds,
in
particular,
intramolecular
HVI-mediated
halocyclisation
alkenes
using
carbon,
oxygen,
nitrogen
or
sulfur
nucleophiles.
Herein,
we
describe
examples
reported
literature,
which
organised
different
halogens
involved
internal
Язык: Английский