Synfacts, Год журнала: 2023, Номер 19(11), С. 1164 - 1164
Опубликована: Окт. 14, 2023
Key words iridium catalysis - benzylation visible-light-promoted reaction
Язык: Английский
Synfacts, Год журнала: 2023, Номер 19(11), С. 1164 - 1164
Опубликована: Окт. 14, 2023
Key words iridium catalysis - benzylation visible-light-promoted reaction
Язык: Английский
Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(11), С. 3119 - 3123
Опубликована: Янв. 1, 2024
A visible-light-mediated radical–radical cross-coupling reaction between hydroxamic acid and N -phenyl glycine derivatives under base metal free conditions is reported. series of unnatural amino acids peptides were obtained in good to excellent yields with chemo-selectivity.
Язык: Английский
Процитировано
7The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(3), С. 1657 - 1668
Опубликована: Янв. 19, 2024
Herein, we report a heterogeneous visible light-driven preparation of α-alkylated glycine derivatives. This approach employed β-ketoenamine-linked covalent organic framework (2D-COF-4) as the photocatalyst and N-hydroxy phthalimide (NHPI) esters alkyl radical sources. Numerous derivatives, including dipeptides, were precisely efficiently alkylated under reaction conditions. Based on excellent photoactivity compatibility 2D-COF-4, this alkylation could proceed flexibly in green solvent (ethanol) without any other additives. The fruitfully recycled with simple workup procedure, revealing high ecoscale value low environmental factor (E-factor).
Язык: Английский
Процитировано
4The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 14, 2025
Dual photoredox and copper-catalyzed remote asymmetric C(sp)3-H alkylation of hydroxamic acid derivatives with glycine via a 1,5-hydrogen transfer (1,5-HAT) process has been realized. The reaction was characterized by redox-neutral mild conditions, good yields, excellent enantioselectivity, broad substrate scope. This protocol provides straightforward efficient strategy to prepare highly valuable enantioenriched noncanonical α-amino acids. Moreover, the potential synthetic value this demonstrated in late-stage dipeptides high diastereomeric ratio.
Язык: Английский
Процитировано
0Tetrahedron Chem, Год журнала: 2025, Номер unknown, С. 100126 - 100126
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0Catalysts, Год журнала: 2023, Номер 13(12), С. 1502 - 1502
Опубликована: Дек. 8, 2023
The glycine motif is widely prevalent in bioactive peptides. Thus, the direct and precise modification of derivatives has attracted significant attention over past few decades. Among various protocols for derivatives, visible-light-driven α-C(sp3)–H bond functionalization emerged as a powerful tool to achieve this objective, owing its merits atom economy, selectivity, reaction simplicity, sustainability. This review summarizes recent advancements derivatives. contents are organized based on photocatalysts employed modes process. mechanism, challenges encountered, future trends also discussed, enabling readers understand current developmental status field.
Язык: Английский
Процитировано
5Synfacts, Год журнала: 2023, Номер 19(11), С. 1164 - 1164
Опубликована: Окт. 14, 2023
Key words iridium catalysis - benzylation visible-light-promoted reaction
Язык: Английский
Процитировано
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