Recent advances on electrochemical generation of sulfonyl radical triggered cyclization of alkene/alkynes
Tetrahedron,
Год журнала:
2025,
Номер
173, С. 134467 - 134467
Опубликована: Янв. 12, 2025
Язык: Английский
Electrochemical Sulfonylation/Cyclization of N-Alkenylacrylamides with Sodium Sulfinates or Sulfonyl Hydrazides
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(15), С. 10660 - 10677
Опубликована: Июль 18, 2024
Two
general
protocols
for
the
regioselective
electrochemically
enabled
sulfonylation
cyclization
of
Язык: Английский
Electrochemical Trifluoromethylation/Bicyclization of N-Cyanamide Alkenes: Synthesis of Bicyclic Amidine Derivatives
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(4), С. 2718 - 2725
Опубликована: Фев. 2, 2024
An
anodically
oxidizing
trifluoromethylation
cascade
of
N-cyanamide
alkene
bearing
two
electronically
differentiated
olefin
moieties
was
reported,
in
which
various
N-unsaturated
acyl
cyanamide
alkenes
and
CF3SO2Na
acting
as
readily
available
starting
materials
furnished
nonaromatic
fused
azaheterobicyclic
compounds
a
highly
efficient
sustainable
manner.
The
broad
substrate
scope,
facile
scalability,
sustainability
enabled
this
electrochemical
process
to
be
an
appealing
complement
for
trifluoromethylated
cyclic
amidines.
Язык: Английский
Electrochemical oxidative CF3 radical-induced lactonization and etherification of terminal and internal alkenes
RSC Advances,
Год журнала:
2025,
Номер
15(19), С. 15302 - 15309
Опубликована: Янв. 1, 2025
Introducing
CF
3
groups
boosts
drug
properties
by
enhancing
metabolic
stability
and
bioavailability.
This
study
reports
an
electrochemical
oxidative
difunctionalization
of
flexible
alkenes
to
form
-substituted
lactones
cyclic
ethers.
Язык: Английский
Electrochemical Trifluoromethylation/Spirocyclization of N-Benzylacrylamides to Construct Trifluoromethylated 2-Azaspiro[4.5]decanes
Chinese Journal of Organic Chemistry,
Год журнала:
2024,
Номер
44(3), С. 981 - 981
Опубликована: Янв. 1, 2024
Язык: Английский
Electrophotocatalytic Thiocyanation and Sulfonylation Cyclization of Unactivated Alkenes
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 18, 2024
We
report
an
electrophotocatalytic
process
that
enables
the
thiocyanation
and
sulfonylation/cyclization
of
alkenes.
It
is
applicable
to
a
wide
range
unactivated
alkenes,
using
inexpensive
photocatalyst
2,4,6-triphenylpyrylium
tetrafluoroborate
(TPPT)
produce
diverse
array
heterocycles
containing
sulfonyl
thiocyano
groups
with
good
functional
group
tolerance.
The
protocol
operates
under
mild,
chemical
oxidant-
transition-metal-free,
broad
scope
substrates.
Preliminary
mechanistic
studies
suggest
reaction
involves
combination
electrolysis
reductive
quenching
photocatalytic
cycle
TPPT.
Язык: Английский
Cobalt‐Catalyzed Oxytrifluoromethylation of N‐Allylamides toward Trifluoromethyl‐Containing Oxazolines
Jun‐Fa Han,
Fang‐Ling Gao,
Lin Chen
и другие.
Asian Journal of Organic Chemistry,
Год журнала:
2024,
Номер
13(3)
Опубликована: Янв. 16, 2024
Abstract
We
herein
report
a
cobalt‐catalyzed
intramolecular
oxytrifluoromethylation
of
N
‐allylamides
for
the
efficient
synthesis
trifluoromethyl‐containing
oxazolines
with
Togni's
reagent
II
as
trifluoromethyl
precursor.
The
protocol
features
mild
reaction
conditions
and
good
functional
group
compatibility.
Preliminary
mechanistic
investigations
suggest
involvement
free
radicals
in
this
transformation.
Язык: Английский