Cobalt‐Catalyzed Oxytrifluoromethylation of N‐Allylamides toward Trifluoromethyl‐Containing Oxazolines DOI Open Access

Jun‐Fa Han,

Fang‐Ling Gao,

Lin Chen

и другие.

Asian Journal of Organic Chemistry, Год журнала: 2024, Номер 13(3)

Опубликована: Янв. 16, 2024

Abstract We herein report a cobalt‐catalyzed intramolecular oxytrifluoromethylation of N ‐allylamides for the efficient synthesis trifluoromethyl‐containing oxazolines with Togni's reagent II as trifluoromethyl precursor. The protocol features mild reaction conditions and good functional group compatibility. Preliminary mechanistic investigations suggest involvement free radicals in this transformation.

Язык: Английский

Recent advances on electrochemical generation of sulfonyl radical triggered cyclization of alkene/alkynes DOI

Jiaqing Shao,

Jiang Liu, Haibo Mei

и другие.

Tetrahedron, Год журнала: 2025, Номер 173, С. 134467 - 134467

Опубликована: Янв. 12, 2025

Язык: Английский

Процитировано

3

Electrochemical Sulfonylation/Cyclization of N-Alkenylacrylamides with Sodium Sulfinates or Sulfonyl Hydrazides DOI
Zhixian Yang,

Lu-Cai Ding,

Gui-Hong Yang

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(15), С. 10660 - 10677

Опубликована: Июль 18, 2024

Two general protocols for the regioselective electrochemically enabled sulfonylation cyclization of

Язык: Английский

Процитировано

8

Electrochemical Trifluoromethylation/Bicyclization of N-Cyanamide Alkenes: Synthesis of Bicyclic Amidine Derivatives DOI

Zhi-Hua Yan,

Yan Yan, Zhonglin Wei

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(4), С. 2718 - 2725

Опубликована: Фев. 2, 2024

An anodically oxidizing trifluoromethylation cascade of N-cyanamide alkene bearing two electronically differentiated olefin moieties was reported, in which various N-unsaturated acyl cyanamide alkenes and CF3SO2Na acting as readily available starting materials furnished nonaromatic fused azaheterobicyclic compounds a highly efficient sustainable manner. The broad substrate scope, facile scalability, sustainability enabled this electrochemical process to be an appealing complement for trifluoromethylated cyclic amidines.

Язык: Английский

Процитировано

4

Electrochemical oxidative CF3 radical-induced lactonization and etherification of terminal and internal alkenes DOI Creative Commons

Riccardo Grigolato,

Tommaso Fantoni,

Giuseppe Autuori

и другие.

RSC Advances, Год журнала: 2025, Номер 15(19), С. 15302 - 15309

Опубликована: Янв. 1, 2025

Introducing CF 3 groups boosts drug properties by enhancing metabolic stability and bioavailability. This study reports an electrochemical oxidative difunctionalization of flexible alkenes to form -substituted lactones cyclic ethers.

Язык: Английский

Процитировано

0

Electrochemical Trifluoromethylation/Spirocyclization of N-Benzylacrylamides to Construct Trifluoromethylated 2-Azaspiro[4.5]decanes DOI
Zhou Lan, Hong He,

De-Qiao Yang

и другие.

Chinese Journal of Organic Chemistry, Год журнала: 2024, Номер 44(3), С. 981 - 981

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

1

Electrophotocatalytic Thiocyanation and Sulfonylation Cyclization of Unactivated Alkenes DOI
Yingchun Ma,

Ping Yu,

Ruoyu Qin

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 18, 2024

We report an electrophotocatalytic process that enables the thiocyanation and sulfonylation/cyclization of alkenes. It is applicable to a wide range unactivated alkenes, using inexpensive photocatalyst 2,4,6-triphenylpyrylium tetrafluoroborate (TPPT) produce diverse array heterocycles containing sulfonyl thiocyano groups with good functional group tolerance. The protocol operates under mild, chemical oxidant- transition-metal-free, broad scope substrates. Preliminary mechanistic studies suggest reaction involves combination electrolysis reductive quenching photocatalytic cycle TPPT.

Язык: Английский

Процитировано

1

Cobalt‐Catalyzed Oxytrifluoromethylation of N‐Allylamides toward Trifluoromethyl‐Containing Oxazolines DOI Open Access

Jun‐Fa Han,

Fang‐Ling Gao,

Lin Chen

и другие.

Asian Journal of Organic Chemistry, Год журнала: 2024, Номер 13(3)

Опубликована: Янв. 16, 2024

Abstract We herein report a cobalt‐catalyzed intramolecular oxytrifluoromethylation of N ‐allylamides for the efficient synthesis trifluoromethyl‐containing oxazolines with Togni's reagent II as trifluoromethyl precursor. The protocol features mild reaction conditions and good functional group compatibility. Preliminary mechanistic investigations suggest involvement free radicals in this transformation.

Язык: Английский

Процитировано

0